FlyBase Allele Report: Dmel\Ubx[MX12]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\Ubx^MX12

General Information

Symbol

Dmel\Ubx^MX12

Species

D. melanogaster

Name

FlyBase ID

FBal0030342

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment 1

(Sanchez-Herrero et al., 1994)

abdominal segment 2

(Sanchez-Herrero et al., 1994)

abdominal segment 3

(Sanchez-Herrero et al., 1994)

abdominal segment 4

(Sanchez-Herrero et al., 1994)

abdominal segment 5

(Sanchez-Herrero et al., 1994)

abdominal segment 6

(Sanchez-Herrero et al., 1994)

abdominal segment 7

(Sanchez-Herrero et al., 1994)

abdominal segment 8

(Sanchez-Herrero et al., 1994)

metathoracic segment

(Sanchez-Herrero et al., 1994)

Detailed Description

Statement

Reference

Ubx^MX12 abd-A^M1 Abd-B^M8 triple mutant embryos exhibit a normal head and anterior thorax, but the third thoracic segment and all the abdominal segments are transformed into the second thoracic segment. Embryos also develop a pair of sclerotic plates in the posterior part of the A8 segment. Heat activation of abd-A^hs.PS transforms the cephalic, thoracic and first abdominal segment into A2-A6 identity. The posterior abdomen exhibits transformation of A8 to the A2-A6 identity and presence of an extra belt in A9.

(Sanchez-Herrero et al., 1994)

The second thoracic to the seventh abdominal segment develop as a composite of compartments from two segments. The identity of the eighth abdominal segment is complex: the anterior has characteristics of prothoracic and mesothoracic segments and the posterior may be cephalic. Ubx^- embryos have an abnormal pattern of Ba expression at the extended germ band stage: Keilin's organs develop in the abdominal segments due to ectopic expression of Ba.

(Simcox et al., 1991)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has abnormal neuroanatomy | somatic clone phenotype

(Parrish et al., 2007)

Phenotype Manifest In

Suppressed by

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | third instar larval stage phenotype, suppressible by Scer\GAL4^VGlut1-OK371/Scer\GAL4^Tub.PU/BacA\p35^UAS.cHa

(Baek et al., 2013)

NOT suppressed by

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has glial cell | third instar larval stage phenotype, non-suppressible by Scer\GAL4^VGlut1-OK371/Scer\GAL4^Tub.PU/BacA\p35^UAS.cHa

(Baek et al., 2013)

Other

Statement

Reference

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | adult stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has motor neuron | somatic clone | third instar larval stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has glial cell | third instar larval stage phenotype

(Baek et al., 2013)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has dendrite & dorsal multidendritic neuron ddaC | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has dendrite & dendritic arborising neuron | somatic clone phenotype

(Parrish et al., 2007)

Antp^Ns-rvC3, Scr^C1, Ubx^MX12 has axon & dendritic arborising neuron | somatic clone phenotype

(Parrish et al., 2007)

Abd-B^S10, Ubx^MX12 has abdominal segment 7 phenotype

(Hendrickson and Sakonju, 1995)

Abd-B^S10, Ubx^MX12 has abdominal segment 5 phenotype

(Hendrickson and Sakonju, 1995)

Abd-B^S10, Ubx^MX12 has abdominal segment 6 phenotype

(Hendrickson and Sakonju, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The number of LinA-derived neurons is dramatically reduced compared to wild type in Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant clones examined at the late third instar larval stage. This phenotype is seen in all three thoracic segments. The number of glia derived from the triple mutant LinA neuroblast clones is also reduced compared to wild type.

Adult motor neurons derived from Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant LinA neuroblast clones target the same region of the leg as do wild-type LinA-derived neurons. However, fewer branches are observed compared with wild-type clones, with the distal region of the tibia being most highly affected.

(Baek et al., 2013)

Single cell class IV dendrite arborisation (da) neuron clones that are triply mutant for Scr^C1, Antp^Ns-rvC3, Ubx^MX12 show severe defects in dendrite growth, branching and coverage in segment T3 as well as axon fasciculation defects. Analysis of Scr^C1, Antp^Ns-rvC3, Ubx^MX12 triple mutant ddaC neuron clones indicates that although the major dendrites of the mutant neurons grow to a similar extent as wild-type controls in the interval between 80 and 96 hours after egg laying, the mutant clones have an increased number of terminal dendrites compared to controls. The mutant clones also show increased dynamic behaviour over this time period compared to controls, due to increased dendrite branch initiation/growth. The number of dendrite retractions is not altered in the mutant neurons.

(Parrish et al., 2007)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa under the simultaneous control of both Scer\GAL4^VGlut-OK371 and Scer\GAL4^tub.PU rescues the reduced number of LinA-derived neurons seen in Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant clones examined at the late third instar larval stage. The reduction in number of glia derived from the triple mutant LinA neuroblast clones is not rescued.

Expression of BacA\p35^Scer\UAS.cHa under the simultaneous control of both Scer\GAL4^VGlut-OK371 and Scer\GAL4^tub.PU partially rescues the defects seen in adult motor neurons of the leg derived from Scr^C1 Antp^Ns-rvC3 Ubx^MX12 triple mutant LinA neuroblast clones.

(Baek et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Ubx^MX12

(Sánchez-Higueras et al., 2019, Pinto et al., 2015, Banreti et al., 2014, Baek et al., 2013, Parrish et al., 2007, Scuderi et al., 2006)

Ubx^Mx12

(Requena et al., 2017, Uhl et al., 2016)

ubx^MX12

(Gebelein and Mann, 2007)

Name Synonyms

Secondary FlyBase IDs

References (29)

Report Sections