Allele Dmel\Ubx^bx-83Kb

General Information
Symbol	Dmel\Ubx^bx-83Kb	Species	D. melanogaster
Name		FlyBase ID	FBal0030347
Feature type	allele	Associated gene	Dmel\Ubx
Also Known As	bx^83Kb, Ubx^bx-83kb

Allele class
Mutagen	spontaneous
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	spontaneous (Peifer and Bender, 1986)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutation in downstream control region. (Irvine et al., 1993) gypsy element insertion into the bx regulatory region. The direction of transcription of the gypsy element is in the opposite direction to Ubx transcription. (Castelli-Gair and Garcia-Bellido, 1990) Insertion of gypsy element, with its direction of transcription in the opposite orientation to the direction of Ubx transcription, into an intron of the Ubx transcription unit. (Little et al., 1990) Insertion of a gypsy element. The gypsy element is transcribed in the same direction as Ubx. (Micol et al., 1990) gypsy insertion at -55kb in the same orientation as Ubx direction of transcription. (Peifer and Bender, 1986)
Caused by insertion	gypsy{}Ubx^bx-83Kb (Little et al., 1990, Micol et al., 1990, Castelli-Gair and Garcia-Bellido, 1990, Martinez-Laborda et al., 1996, Lindsley and Zimm, 1992, Peifer and Bender, 1986)
Cytology	Polytene chromosomes normal. (Castelli-Gair and Garcia-Bellido, 1990)
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	haltere (Peifer and Bender, 1986) katepimeron (Peifer and Bender, 1986) metathoracic leg \| anterior (Peifer and Bender, 1986) metathoracic segment \| dorsal (Peifer and Bender, 1986)
Detailed Description
	Statement Reference Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52. (Castelli-Gair and Garcia-Bellido, 1990) Haltere are transformed to wing and are 20-25% of wing size, dorsal tissue of T3 is incompletely transformed to metanotum, hypopleural plates are incompletely transformed to sternopleural plates, 9-10 hypopleural bristles are still present and the anterior third leg displays a strong transformation to anterior second leg, as seen by the bristle pattern. Phenotype can be suppressed by su(Hw) mutations. (Peifer and Bender, 1986)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Ubx[+]/Ubx^bx-83Kb is an enhancer of visible \| homeotic phenotype of Dsp1¹ (Decoville et al., 2001)
Phenotype Manifest In
Enhancer of
Statement Reference Ubx[+]/Ubx^bx-83Kb is an enhancer of haltere phenotype of Dsp1¹ (Decoville et al., 2001) Ubx[+]/Ubx^bx-83Kb is an enhancer of wing \| ectopic phenotype of Dsp1¹ (Decoville et al., 2001)
Additional Comments
Genetic Interactions
Statement Reference The frequency of transformation of halteres into wings seen in Dsp1¹/Y flies is enhanced by Ubx^bx-83Kb/+. The enhancement is dramatically reduced if the female parents are heterozygous rather than homozygous for Dsp1¹. (Decoville et al., 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Kyoto	101578 Ubx^bx-83Kb / TM1, Me¹ kni^ri-1 Sb^sbd-l
Notes on Origin
Discoverer	Kuhn. Kuhn, 1983.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	bx^83Kb (Martinez-Laborda et al., 1996, Little et al., 1990, Micol et al., 1990, Castelli-Gair and Garcia-Bellido, 1990) bx^83kb (Qian et al., 1991, Peifer and Bender, 1986) bx^83kd (Decoville et al., 2001) bx^Kb (Lindsley and Zimm, 1992) Ubx^83kd (Decoville et al., 2001) Ubx^bx-83kb (Decoville et al., 2001, Irvine et al., 1993) Ubx^bx-83Kb Ubx^bx-Kb (Lindsley and Zimm, 1992)
Name Synonym
Secondary FlyBase IDs
	FBal0017530
References ( 9 )
Research paper	Decoville et al., 2001, Genetics 157(1): 237--244 DSP1, an HMG-like protein, is involved in the regulation of homeotic genes. [FBrf0132331] Martinez-Laborda et al., 1996, Mol. Gen. Genet. 250(5): 540--546 A genetic analysis of bx bxd cis double mutants in the Drosophila Ultrabithorax gene. [FBrf0087590] Irvine et al., 1993, Development 117(1): 387--399 Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. [FBrf0064522] Qian et al., 1991, EMBO J. 10: 1415--1425 The bx region enhancer, a distant cis-control element of the Drosophila Ubx gene and its regulation by hunchback and other segmentation genes. [FBrf0053871] Castelli-Gair and Garcia-Bellido, 1990, EMBO J. 9: 4267--4275 Interactions of Polycomb and trithorax with cis regulatory regions of Ultrabithorax during the development of Drosophila melanogaster. [FBrf0051664] Little et al., 1990, Genetics 124: 899--908 Effect of abx, bx and pbx mutations on expression of homeotic genes in Drosophila larvae. [FBrf0051987] Micol et al., 1990, Genetics 126: 365--373 Genetic analysis of transvection effects involving cis-regulatory elements of the Drosophila Ultrabithorax gene. [FBrf0051939] Peifer and Bender, 1986, EMBO J. 5: 2293--2303 The anterobithorax and bithorax mutations of the Bithorax complex. [FBrf0044226]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\Ubxbx-83Kb

Allele Dmel\Ubx^bx-83Kb