Allele Dmel\ato^Scer\UAS.cJa

General Information
Symbol	Dmel\ato^Scer\UAS.cJa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Jarman	FlyBase ID	FBal0030530
Feature type	allele	Associated gene	Dmel\ato

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Jarman et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of ato under influence of Scer\GAL4 UAS. (Jarman et al., 1993)
Carried in construct	P{UAS-ato.J} (Apitz et al., 2005, Zlatic et al., 2003, Rawlins et al., 2003, Jiao et al., 2001, Frankfort et al., 2001, Jhaveri and Rodrigues, 2002, Jarman et al., 1993, Jafar-Nejad et al., 2003, Quan et al., 2004, Jhaveri et al., 2004, White and Jarman, 2000, Nolo et al., 2000, Sun et al., 2000, Jhaveri et al., 2000, Jarman et al., 1994, Jhaveri et al., 2000, Goulding et al., 2000, Huang et al., 2000, Hassan et al., 2000, Chanut et al., 2000, Baonza et al., 2001, Jarman and Ahmed, 1998, Baker et al., 1996, Lai, 2003, Gupta and Rodrigues, 1997, Dokucu et al., 1996, Li et al., 2009, Brown et al., 2006, Holohan et al., 2006, zur Lage et al., 2004, Li-Kroeger et al., 2008, Witt et al., 2010, Aerts et al., 2010, Cachero et al., 2011, Powell et al., 2004, Powell et al., 2008, Sun et al., 2003, Bhattacharya and Baker, 2011, Kahali et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pharate adult stage, with Scer\GAL4^ptc-559.1 (Jarman and Ahmed, 1998) visible, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) visible, with Scer\GAL4³⁸⁴ (Gupta and Rodrigues, 1997) visible, with Scer\GAL4^dpp.blk1 (Li et al., 2009) visible, with Scer\GAL4^ey.PH (Jiao et al., 2001) visible, with Scer\GAL4^hs.PB (Huang et al., 2000) visible, with Scer\GAL4^ptc-559.1 (Jarman and Ahmed, 1998) visible, with Scer\GAL4^sca-109-68 (White and Jarman, 2000, Rawlins et al., 2003)
Phenotype Manifest In
	abdominal basiconical sensillum dbd & larva & nerve terminal, with Scer\GAL4^sca.PC (Zlatic et al., 2003) abdominal sternite bristle, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) adult head, with Scer\GAL4^ey.PH (Jiao et al., 2001) adult thorax & macrochaeta, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) chordotonal organ, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) chordotonal organ & wing \| ectopic, with Scer\GAL4^dpp.blk1 (Quan et al., 2004) chordotonal organ \| ectopic, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) chordotonal organ \| ectopic, with Scer\GAL4^h-1J3 (Goulding et al., 2000) chordotonal organ \| ectopic, with Scer\GAL4^hs.PB (Jarman and Ahmed, 1998, Jarman et al., 1993) chordotonal organ \| ectopic, with Scer\GAL4^sca-109-68 (Goulding et al., 2000) eye, with Scer\GAL4^ey.PH (Jiao et al., 2001) eye, with Scer\GAL4^sca-109-68 (White and Jarman, 2000) eye photoreceptor cell, with Scer\GAL4^sca-109-68 (White and Jarman, 2000) eye photoreceptor cell \| ectopic, with Scer\GAL4^sca-109-68 (White and Jarman, 2000) lobula, with Scer\GAL4^ato.3.6 (Hassan et al., 2000) macrochaeta, with Scer\GAL4^hs.PB (Jarman and Ahmed, 1998) macrochaeta & wing \| ectopic, with Scer\GAL4^dpp.blk1 (Quan et al., 2004) medulla, with Scer\GAL4^ato.3.6 (Hassan et al., 2000) morphogenetic furrow \| somatic clone, with Scer\GAL4^GMR.PF (Brown et al., 2006) multidendritic neuron \| ectopic, with Scer\GAL4^sca-537.4 (Huang et al., 2000) ommatidial precursor cluster \| somatic clone, with Scer\GAL4^GMR.PF (Brown et al., 2006) ommatidium, with Scer\GAL4^sca-109-68 (White and Jarman, 2000, Rawlins et al., 2003) optic chiasm, with Scer\GAL4^ato.3.6 (Hassan et al., 2000) photoreceptor cell R7 \| ectopic, with Scer\GAL4^sca-109-68 (White and Jarman, 2000) photoreceptor cell R8, with Scer\GAL4^hs.PB (Dokucu et al., 1996) photoreceptor cell R8, with Scer\GAL4^sca-109-68 (White and Jarman, 2000) photoreceptor cell R8 \| ectopic, with Scer\GAL4^hs.PB (Dokucu et al., 1996) photoreceptor cell R8 \| supernumerary, with Scer\GAL4^sca-109-68 (Rawlins et al., 2003) sacculus \| ectopic, with Scer\GAL4³⁸⁴ (Gupta and Rodrigues, 1997) scolopidial neuron \| ectopic, with Scer\GAL4^sca-537.4 (Huang et al., 2000) scutellar bristle \| ectopic, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) scutellar bristle \| ectopic, with Scer\GAL4^dpp.blk1 (Li et al., 2009) scutum, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) sensillum basiconicum, with Scer\GAL4^{neur-GAL4-A101} (Jhaveri et al., 2000) sensillum basiconicum of antennal segment 3, with Scer\GAL4^{neur-GAL4-A101} (Jhaveri et al., 2000) sensillum campaniformium of anterior crossvein, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) sensillum coeloconicum \| ectopic, with Scer\GAL4^{neur-GAL4-A101} (Jhaveri et al., 2000) sensillum coeloconicum of antennal segment 3 \| supernumerary, with Scer\GAL4^{neur-GAL4-A101} (Jhaveri et al., 2000) sensillum trichodeum, with Scer\GAL4^{neur-GAL4-A101} (Jhaveri et al., 2000) sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4^ptc-559.1 (Jarman and Ahmed, 1998) sensory mother cell \| ectopic, with Scer\GAL4^ptc-559.1 (Jarman and Ahmed, 1998) sternopleural bristle \| ectopic, with Scer\GAL4^dpp.blk1 (Li et al., 2009) wing, with Scer\GAL4^ptc-559.1 (Jarman and Ahmed, 1998) wing sensillum, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998) wing sensillum \| ectopic, with Scer\GAL4^hs.PB (Huang et al., 2000) wing vein L3, with Scer\GAL4¹⁰⁹ (Jarman and Ahmed, 1998)
Detailed Description
	Statement Reference Ectopic expression of ato[Scer\UAS.cJa] anterior to the morphogenetic furrow, under the control of Scer\GAL4[Scer\FRT.Rnor\CD2.Act5C] does not lead to premature differentiation. (Bhattacharya and Baker, 2011) Expression of ato[Scer\UAS.cJa] with Scer\GAL4[sca-109-68] does not elicit overt eye/R8 defects at 24[o]C. (Kahali et al., 2009) Flies expressing ato[Scer\UAS.cJa] under the control of Scer\GAL4[dpp.blk1] have ectopic sternopleural and scutellar bristles. (Li et al., 2009) Clones that express ato^Scer\UAS.cJa behind the morphogenetic furrow of the eye disc, driven by Scer\GAL4^GMR.PF, leads to disorganised clusters with many cells having upregulated adherens junction components. (Brown et al., 2006) ato^Scer\UAS.cJa; Scer\GAL4^dpp.blk1 flies have large numbers of ectopic sensory bristles around the A-P compartment boundary of their wings, along with ectopic chordotonal organs. (Quan et al., 2004) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 results in a rough eye phenotype. Some R8 twinning is seen in the mutant ommatidia. (Rawlins et al., 2003) When expression is driven in the PNS by Scer\GAL4^sca.PC, the larval dbd neuron projection is shifted ventrally and from the medial to the intermediate longitudinal fascicle and, in pronounced cases, the dbd-characteristic ventral extension no longer occurs. Late remodelling of the dbd terminal also does not occur. The major CNS axon fascicles are wild type and the larvae hatch. (Zlatic et al., 2003) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^SG18.1 or Scer\GAL4^{neur-GAL4-A101} does not affect the formation of the antennal glomeruli. (Jhaveri and Rodrigues, 2002) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^ey.PH gives rise to animals in which most of the head and one or both eyes of reduced size are present. (Jiao et al., 2001) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^unspecified results in no or very few ectopic olfactory-like sensilla. (Goulding et al., 2000) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 produce densely packed arrays of ectopic chordotonal organs. Misexpression of ato^Scer\UAS.cJa driven by Scer\GAL4^h-1J3 results in expansion of lateral chordotonal organ clusters (usually 6-10 neurons instead of 5) but the neurons are of normal morphology. (Goulding et al., 2000) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^ato.3.6 results in excessive branching in the lobula and the medulla as compared to wild type. The organisation of the ato-expressing dorsal cluster, its size and its position are unaffected in third larval instar and adult brains. The number of axons crossing the optic chiasma, but not their morphology, is wild type. (Hassan et al., 2000) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-537.4 slightly induces the formation of multiple dendritic neurons in embryos. A slight increase in the number of chordotonal neurons in the lateral region is also seen. Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB using a 10 minute heat shock just after puparium formation results in ectopic bristles in the wing. (Huang et al., 2000) When ato^Scer\UAS.cJa is driven by Scer\GAL4^{neur-GAL4-A101}, Many of the basiconic and trichoid sensilla of the antenna are converted to a coeloconic lineage, leading to an increase in the latter type of sense organs. Glial cell number is significantly increased and these cells now appear at ectopic positions on the antenna. (Jhaveri et al., 2000) When ato^Scer\UAS.cJa is driven by Scer\GAL4^{neur-GAL4-A101} a reduction is seen in basiconica and trichoidea and a concomitant increase in coeloconic sensilla. This appears to be a conversion of other sensilla to "ectopic coeloconica". (Jhaveri et al., 2000) Flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 have rough eyes, with many ommatidia containing inappropriate complements of photoreceptors and support cells (there can be an increase or a decrease in any specific cell type). This phenotype results from a combination of recruitment and R8 spacing defects. Ommatidial spacing is abnormal and there appear to be fused ommatidia. R8 cells are more dense, frequently juxtaposed (twinned) and unevenly spaced relative to one another. The phenotype is non-autonomous; the presence of supernumerary cells is not always correlated with ectopic ato expression within them. The ommatidia are no longer arranged in straight rows and ectopic photoreceptors infrequently differentiate in the interommatidial spaces. Supernumerary R7 photoreceptors are frequently seen in these flies. (White and Jarman, 2000) Flies expressing low levels of ato^Scer\UAS.cJa under the control of Scer\GAL4¹⁰⁹ have ectopic bristles on the scutellum, on the dorsocentral notum and wing vein L3. A small number of ectopic chordotonal organs are detected under the cuticle of the scutellum and vein L3. The wild-type chordotonal organs are hyperplastic, consisting of more aligned scolopidia or individual chordotonal unit organs. Flies expressing higher levels of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB show only the ectopic chordotonal organ phenotype. In many places the formation of ectopic chordotonal organs coincides with bristle loss in these flies. In some cases, when expression is driven by Scer\GAL4¹⁰⁹, external sense organs are malformed and are associated with scolopales, suggesting an incomplete transformation to chordotonal organs. External sense organs affected in this way include the sternitals of the ventral abdomen, the wing sense organs ACV and TSM1+2 and in extreme cases all other thoracic macrochaetae. Extra sensory organ precursors are seen in the wing discs of flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4¹⁰⁹. Flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^ptc-559.1 are not viable and die as pharate adults with deformed wings and appendages. Ectopic sensory organ precursors are seen in the wing discs of these animals. (Jarman and Ahmed, 1998) Scer\GAL4³⁸⁴-mediated expression causes duplication of the antenna sacculus in a position near to the normal sacculus. (Gupta and Rodrigues, 1997) Scer\GAL4^hs.PB mediated expression causes a slightly irregular ommatidial pattern: ectopic R8 cells in several ommatidia due to transformation of all 2-3 cells within the R8 equivalence group. Multiple R8 cells are observed in ommatidia that were within the morphogenetic furrow at the time of heat shock. (Dokucu et al., 1996) Fifteen minute heat shock pulse during larval development allows spatially restricted rescue of ommatidia. A row of ommatidia is formed within the pigment cell patch, ommatidia are of variable size. Longer or multiple heat shocks result in pupal death. (Jarman et al., 1994) When ato is ectopically expressed, large numbers of ectopic chordotonal organs develop. (Jarman et al., 1993)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by Dl^9P (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by ed[+]/ed^4.12 (Rawlins et al., 2003) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by h^unspecified (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by hh^Scer\UAS.cSa (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by ptc⁵ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, enhanceable by ro¹ (White and Jarman, 2000)
Suppressed by
Statement Reference Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible \| partially by Egfr^f3 (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible by ci^unspecified/ci[+] (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible by dos^unspecified (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible by hh[+]/hh^AC (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible by phl¹ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has visible phenotype, suppressible by Ras85D^e2F (White and Jarman, 2000)
Suppressor of
Statement Reference ato^Scer\UAS.cJa/Scer\GAL4^h-H10 is a suppressor of visible phenotype of ro^DOM (Chanut et al., 2000)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa, sev¹⁴ has photoreceptor cell R7 phenotype, enhanceable by Egfr^f3 (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, enhanceable by Dl^9P (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, enhanceable by h^unspecified (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, enhanceable by hh^Scer\UAS.cSa (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, enhanceable by ptc⁵ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, enhanceable by ro¹ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, enhanceable by Dl^9P (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, enhanceable by ed[+]/ed^4.12 (Rawlins et al., 2003) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, enhanceable by h^unspecified (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, enhanceable by ptc⁵ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, enhanceable by ro¹ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has photoreceptor cell R8 \| supernumerary phenotype, enhanceable by ed[+]/ed^4.12 (Rawlins et al., 2003)
Suppressed by
Statement Reference Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible \| partially by Egfr^f3 (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible by ci^unspecified/ci[+] (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible by dos^unspecified (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible by hh[+]/hh^AC (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible by phl¹ (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has eye phenotype, suppressible by Ras85D^e2F (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, suppressible by ci^unspecified/ci[+] (White and Jarman, 2000) Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa has ommatidium phenotype, suppressible by hh[+]/hh^AC (White and Jarman, 2000)
Enhancer of
Statement Reference Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}/ato^Scer\UAS.cJa is an enhancer of eye disc \| somatic clone phenotype of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}, da^{Δex1.Scer\UAS} (Bhattacharya and Baker, 2011) Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}/ato^Scer\UAS.cJa is an enhancer of eye disc anterior to the morphogenetic furrow \| somatic clone phenotype of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}, da^{Δex1.Scer\UAS} (Bhattacharya and Baker, 2011) Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}/ato^Scer\UAS.cJa is an enhancer of morphogenetic furrow \| somatic clone phenotype of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}, da^{Δex1.Scer\UAS} (Bhattacharya and Baker, 2011)
NOT Enhancer of
Statement Reference ato^Scer\UAS.cJa, Scer\GAL4^ato.3.6 is a non-enhancer of lobula phenotype of N^{intra.GS.Scer\UAS}, Scer\GAL4^ato.3.6 (Hassan et al., 2000) ato^Scer\UAS.cJa, Scer\GAL4^ato.3.6 is a non-enhancer of medulla phenotype of N^{intra.GS.Scer\UAS}, Scer\GAL4^ato.3.6 (Hassan et al., 2000)
Suppressor of
Statement Reference ato^Scer\UAS.cJa, Scer\GAL4^sca-109-68 is a suppressor of eye phenotype of E(spl)m8-HLH^SD.Scer\UAS, Scer\GAL4^sca-109-68 (Kahali et al., 2009) ato^Scer\UAS.cJa, Scer\GAL4^sca-109-68 is a suppressor of eye photoreceptor cell phenotype of E(spl)m8-HLH^SD.Scer\UAS, Scer\GAL4^sca-109-68 (Kahali et al., 2009) ato^Scer\UAS.cJa/Scer\GAL4^h-H10 is a suppressor of eye phenotype of ro^DOM (Chanut et al., 2000) ato^Scer\UAS.cJa/Scer\GAL4^sca-109-68 is a suppressor of photoreceptor cell R7 phenotype of sev¹⁴ (White and Jarman, 2000)
NOT Suppressor of
Statement Reference ato^Scer\UAS.cJa, Scer\GAL4^ato.3.6 is a non-suppressor of lobula phenotype of N^{intra.GS.Scer\UAS}, Scer\GAL4^ato.3.6 (Hassan et al., 2000) ato^Scer\UAS.cJa, Scer\GAL4^ato.3.6 is a non-suppressor of medulla phenotype of N^{intra.GS.Scer\UAS}, Scer\GAL4^ato.3.6 (Hassan et al., 2000) ato^Scer\UAS.cJa is a non-suppressor of sensillum basiconicum phenotype of Scer\GAL4^hs.PB, lz³ (Goulding et al., 2000) Scer\GAL4^GMR.PF, Scer\GAL4^GMR.PF, ato^Scer\UAS.cJa is a non-suppressor of ommatidial precursor cluster \| somatic clone phenotype of Ras85D^ΔC40B (Brown et al., 2006)
Other
Statement Reference Egfr^f3, Scer\GAL4^sca-109-68, ato^Scer\UAS.cJa, sev¹⁴ has photoreceptor cell R7 phenotype (White and Jarman, 2000) Scer\GAL4^hs.PB, ato^Scer\UAS.cJa, lz³ has sensillum coeloconicum phenotype (Goulding et al., 2000, Goulding et al., 2000)
Additional Comments
Genetic Interactions
Statement Reference Approximately 81% of cells overexpressing both ato[Scer\UAS.cJa] and da[Δex1.Scer\UAS] ahead of the morphogenetic furrow (under the control of Scer\GAL4[Scer\FRT.Rnor\CD2.Act5C]) differentiate into neurons. (Bhattacharya and Baker, 2011) The eye and photoreceptor defects caused by expression of E(spl)m8-HLH[SD.Scer\UAS] with Scer\GAL4[sca-109-68] are suppressed by co-expression of ato[Scer\UAS.cJa]. (Kahali et al., 2009) Expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^GMR.PF fails to suppress the morphogenetic furrow phenotype of Ras85D^ΔC40B clones. (Brown et al., 2006) The rough eye phenotype and R8 twinning phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 is dominantly enhanced by ed^4.12. (Rawlins et al., 2003) When expression is driven by Scer\GAL4^h-H10 in an ro^DOM mutant, the stop-furrow phenotype of ro^DOM is suppressed. (Chanut et al., 2000) The reduction in number of sensilla basiconica seen in lz³ flies is not rescued by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^hs.PB even though the number of sensilla coeloconica is increased. (Goulding et al., 2000) Expression of N^{intra.GS.Scer\UAS} under the control of Scer\GAL4^ato.3.6 results in a severe inhibition of axonal branching over the lobula and a complete failure of innervation of the medulla. This phenotype is not altered by coexpression of ato^Scer\UAS.cJa. (Hassan et al., 2000) Egfr^f3 suppresses the recruitment defects in the eye caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68, although abnormal pattern formation still occurs. ro¹, ptc⁵, h^unspecified or Dl^9P enhance the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68. hh^AC or ci^unspecified suppress the rough eye phenotype caused by expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68. The eye is extremely disorganised when both ato^Scer\UAS.cJa and hh^Scer\UAS.cSa are expressed under the control of Scer\GAL4^sca-109-68. Many R7 cells differentiate in sev¹⁴ flies expressing ato^Scer\UAS.cJa under the control of Scer\GAL4^sca-109-68 (in contrast to sev¹⁴ flies which lack R7 photoreceptors). This rescue of R7 formation by ato^Scer\UAS.cJa expressed under the control of Scer\GAL4^sca-109-68 is strongly suppressed if the flies are also carrying Egfr^f3. (White and Jarman, 2000)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	ato^Scer\UAS.cJa/Scer\GAL4^ato.3.6 rescues ato¹/Df(3R)p13 (Hassan et al., 2000)
Fails to rescue	Scer\GAL4^SG18.1/ato^Scer\UAS.cJa fails to rescue ato¹/Df(3R)p13 (Jhaveri and Rodrigues, 2002)
Comments	Expression of ato[Scer\UAS.cJa] under the control of Scer\GAL4[7] restores the formation of R8 photoreceptor cells and numerous ommatidia in ato[1] flies. (Sun et al., 2003) Expression of ato^Scer\UAS.cJa under the control of Scer\GAL4^SG18.1 does not rescue the lack of antennal glomeruli seen in ato¹/Df(3R)p13 mutants. (Jhaveri and Rodrigues, 2002) The lobular innervation pattern defect of ato¹/Df(3R)p13 flies is rescued by ato^Scer\UAS.cJa expressed under the control of Scer\GAL4^ato.3.6. (Hassan et al., 2000)
Stocks ( 1 )
Bloomington	39679 w^*; P{UAS-ato.J}8/TM3, Sb¹
Notes on Origin
Discoverer

Comments
	Used to ectopically express ato via a heat shock Scer\GAL4 construct. (Jarman et al., 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	ato^Scer\UAS.cJa ato^UAS.cJa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Jarman
Secondary FlyBase IDs

References ( 40 )

Generate a list of	All references relating to this allele ( 40 )

List References by type	Research paper ( 40 )
Recent research papers ( 2 )
	Bhattacharya and Baker, 2011, Cell 147(4): 881--892 A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates. [FBrf0216641] Cachero et al., 2011, PLoS Biol. 9(1): e1000568 The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. [FBrf0212891] Show all research papers ...

Allele Dmel\atoScer\UAS.cJa

Allele Dmel\ato^Scer\UAS.cJa