Allele Dmel\cas^Δ3

General Information
Symbol	Dmel\cas^Δ3	Species	D. melanogaster
Name		FlyBase ID	FBal0030722
Feature type	allele	Associated gene	Dmel\cas

Allele class	amorphic allele - genetic evidence
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - genetic evidence (Zhang et al., 1996)
Mutagen	Delta2-3 (Mellerick et al., 1992, Zhang et al., 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{enH+Hox.A}plx^23A (Mellerick et al., 1992, Zhang et al., 1996)
Nature of the lesion	Statement Reference Deletion of cas sequences. (Zhang et al., 1996) Imprecise excision of the P{enH+Hox.A} element causing deletion of cas sequences. (Mellerick et al., 1992)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Mellerick et al., 1992) lethal \| recessive (Kambadur et al., 1998)
Phenotype Manifest In
	presumptive embryonic/larval central nervous system (Mellerick et al., 1992)
Detailed Description
	Statement Reference Homozygous embryos fail to exit the egg chambers and show no signs of movement although they are fully developed with normal cuticles and wild type denticle belts. Their CNS network is reduced. (Mellerick et al., 1992)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	cas^H23AΔ3 (Clements et al., 2003) cas^Δ3 (Benito-Sipos et al., 2011, Baumgardt et al., 2009) unnamed (Zhang et al., 1996)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Benito-Sipos et al., 2011, Development 138(24): 5311--5320 Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. [FBrf0216799] Baumgardt et al., 2009, Cell 139(5): 969--982 Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. [FBrf0209429] Clements et al., 2003, Dev. Dyn. 226(1): 67--81 Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development. [FBrf0155691] Kambadur et al., 1998, Genes Dev. 12(2): 246--260 Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. [FBrf0100094] Zhang et al., 1996, Genes Dev. 10(9): 1108--1119 Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man. [FBrf0087805] Mellerick et al., 1992, Neuron 9: 789--803 castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila. [FBrf0057370]

Allele Dmel\casΔ3

Allele Dmel\cas^Δ3