|Feature type||allele||Associated gene||Dmel\Nrg|
|Also Known As||ceb2, ceb892|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Nrg/Nrg females show normal sexual receptivity when mated to wild-type males. Homozygous females show a moderate reduction in sexual receptivity (56% mate) compared to wild-type controls when mated to wild-type males. Nrg[l4]/Nrg, Nrg[G0099]/Nrg, Nrg[G0413]/Nrg and Nrg[G0488b]/Nrg females show reduced sexual receptivity compared to wild-type controls when mated to wild-type males. Nrg[l10]/Nrg females show normal sexual receptivity at 18 and 25[o]C, but show reduced receptivity at 29[o]C when mated to wild-type males. Homozygous males show defects in courtship behaviour relative to wild-type controls when mated to wild-type females. The mean latency is not significantly different from wild type, but they show significantly extended mating speeds. Once they are courting a female, the mutant males tend to have more breaks in their courtship than normal.
Flies have a number of brain defects, the exact phenotype depending on the genetic background. In the original genetic background in which it was induced, Nrg892 has a similar phenotype to that of Nrg849, but the mushroom body defects are less severe. The peduncle and lobes are present but poorly developed. All flies have ellipsoid body defects, and most flies have fan-shaped body defects. Females are sterile. When placed in a Canton S background, the Nrg892 phenotype is altered, with the mushroom body and central complex phenotypes becoming more severe.
Abnormalities in central body and mushroom body. About 400 Kenyon cell fibers miss the fiber bundle of pedicle, forming an extra lobe on lateral side of calyx. Ellipsoid body abnormal, being divided into 2 parts along the midline, or opening ventrally.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
Nrg[ibx] and Nrg complement each other with respect to the reduced female receptivity phenotype seen in each homozygote. Nrg[l4], Nrg[G0099], Nrg[G0413] and Nrg[G0488b] each fail to complement the reduced female receptivity phenotype of Nrg. Nrg[l7] complements the reduced female receptivity phenotype of Nrg. Nrg[l10] complements the reduced female receptivity phenotype of Nrg at 18 and 25[o]C, but fails to complement this phenotype at 29[o]C.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 4 )|
|Secondary FlyBase IDs|
|References ( 5 )|