Allele Dmel\Nrg⁸⁹²

General Information
Symbol	Dmel\Nrg⁸⁹²	Species	D. melanogaster
Name		FlyBase ID	FBal0030739
Feature type	allele	Associated gene	Dmel\Nrg
Also Known As	ceb², ceb⁸⁹²

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| female (with Nrg^G0099) (Carhan et al., 2005) courtship behavior defective \| female (with Nrg^G0413) (Carhan et al., 2005) courtship behavior defective \| female (with Nrg^G0488b) (Carhan et al., 2005) courtship behavior defective \| female (with Nrg^l4) (Carhan et al., 2005) courtship behavior defective \| female \| heat sensitive (with Nrg^l10) (Carhan et al., 2005) courtship behavior defective \| female \| recessive (Carhan et al., 2005) courtship behavior defective \| male (Carhan et al., 2005) viable (Strauss and Heisenberg, 1993)
Phenotype Manifest In
	adult central complex (Strauss and Heisenberg, 1993, de Belle and Heisenberg, 1996) ellipsoid body (Strauss and Heisenberg, 1993, de Belle and Heisenberg, 1996) fan-shaped body (de Belle and Heisenberg, 1996) Kenyon cell (Strauss and Heisenberg, 1993) lobe system of mushroom body (de Belle and Heisenberg, 1996) mushroom body (Strauss and Heisenberg, 1993, de Belle and Heisenberg, 1996)
Detailed Description
	Statement Reference Nrg[849]/Nrg[892] females show normal sexual receptivity when mated to wild-type males. Homozygous females show a moderate reduction in sexual receptivity (56% mate) compared to wild-type controls when mated to wild-type males. Nrg[l4]/Nrg[892], Nrg[G0099]/Nrg[892], Nrg[G0413]/Nrg[892] and Nrg[G0488b]/Nrg[892] females show reduced sexual receptivity compared to wild-type controls when mated to wild-type males. Nrg[l10]/Nrg[892] females show normal sexual receptivity at 18 and 25[o]C, but show reduced receptivity at 29[o]C when mated to wild-type males. Homozygous males show defects in courtship behaviour relative to wild-type controls when mated to wild-type females. The mean latency is not significantly different from wild type, but they show significantly extended mating speeds. Once they are courting a female, the mutant males tend to have more breaks in their courtship than normal. (Carhan et al., 2005) Flies have a number of brain defects, the exact phenotype depending on the genetic background. In the original genetic background in which it was induced, Nrg⁸⁹² has a similar phenotype to that of Nrg⁸⁴⁹, but the mushroom body defects are less severe. The peduncle and lobes are present but poorly developed. All flies have ellipsoid body defects, and most flies have fan-shaped body defects. Females are sterile. When placed in a Canton S background, the Nrg⁸⁹² phenotype is altered, with the mushroom body and central complex phenotypes becoming more severe. (de Belle and Heisenberg, 1996) Abnormalities in central body and mushroom body. About 400 Kenyon cell fibers miss the fiber bundle of pedicle, forming an extra lobe on lateral side of calyx. Ellipsoid body abnormal, being divided into 2 parts along the midline, or opening ventrally. (Strauss and Heisenberg, 1993)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	Nrg^ibx (Carhan et al., 2005) Nrg^l7 (Carhan et al., 2005) Nrg^l10 (Carhan et al., 2005)
Fails to complement	Nrg^l10 (Carhan et al., 2005)
Comments	Nrg[ibx] and Nrg[892] complement each other with respect to the reduced female receptivity phenotype seen in each homozygote. Nrg[l4], Nrg[G0099], Nrg[G0413] and Nrg[G0488b] each fail to complement the reduced female receptivity phenotype of Nrg[892]. Nrg[l7] complements the reduced female receptivity phenotype of Nrg[892]. Nrg[l10] complements the reduced female receptivity phenotype of Nrg[892] at 18 and 25[o]C, but fails to complement this phenotype at 29[o]C. (Carhan et al., 2005)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	cbd⁸⁹² (Scholz et al., 2000) ceb² (de Belle and Heisenberg, 1996, Carhan et al., 2005) ceb⁸⁹² (Ferrus and Canal, 1994, Strauss and Heisenberg, 1993, ) Nrg⁸⁹²
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Carhan et al., 2005, Genes Brain Behav. 4(8): 449--465 Female receptivity phenotype of icebox mutants caused by a mutation in the L1-type cell adhesion molecule neuroglian. [FBrf0190532] Scholz et al., 2000, Neuron 28(1): 261--271 Functional ethanol tolerance in Drosophila. [FBrf0131396] de Belle and Heisenberg, 1996, Proc. Natl. Acad. Sci. U.S.A. 93(18): 9875--9880 Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: A case study of the mushroom body miniature gene (mbm). [FBrf0090884] Strauss and Heisenberg, 1993, J. Neurosci. 13(5): 1852--1861 A higher control center of locomotor behavior in the Drosophila brain. [FBrf0058917]
Review	Ferrus and Canal, 1994, Trends Neurosci. 17(11): 479--486 The behaving brain of a fly. [FBrf0078379]

Allele Dmel\Nrg892

Allele Dmel\Nrg⁸⁹²