Allele Dmel\cex^KS181

General Information
Symbol	Dmel\cex^KS181	Species	D. melanogaster
Name		FlyBase ID	FBal0030740
Feature type	allele	Associated gene	Dmel\cex
Also Known As	cex¹

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	behavior defective \| larval stage (Varnam and Sokolowski, 1995) locomotor behavior defective (Martin et al., 1999) locomotor behavior defective \| larval stage \| recessive (Varnam et al., 1996) neuroanatomy defective (Strauss and Heisenberg, 1993) viable (Varnam and Sokolowski, 1995, Strauss and Heisenberg, 1993)
Phenotype Manifest In
	ellipsoid body (Strauss and Heisenberg, 1993) fan-shaped body (Strauss and Heisenberg, 1993) nodulus (Strauss and Heisenberg, 1993) protocerebral bridge (Martin et al., 1999, Strauss and Heisenberg, 1993)
Detailed Description
	Statement Reference Show significantly reduced ability to develop ethanol tolerance. (Scholz et al., 2000) The architecture of the protocerebral bridge is disturbed in cex^KS181 adult brains; it looks more 'glomerular' than wild type. Total walking activity is significantly decreased in comparison to wild-type flies. Episodes of high walking probability occur as frequently as in wild-type flies, but these episodes are of much shorter duration than in wild type. (Martin et al., 1999) Homozygous larvae show reduced locomotor behaviour (shorter path lengths) on agar (non-foraging surface) and yeast (foraging surface) compared to controls. Larvae are slower than controls in a roll over test. (Varnam et al., 1996) Protocerebral bridge of central body segmented showing its 16 glomeruli. Fan shaped body and ellipsoid body affected along the midline, often with a cleft in the fan body and a ventral opening in the ellipsoid body. Noduli occasionally fragmented or fused. (Strauss and Heisenberg, 1993)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Strains differ from wild type in one or more larval behavioural assays. (Varnam and Sokolowski, 1995)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cex¹ (Scholz et al., 2000, Hitier et al., 2000, Martin et al., 1999, Varnam et al., 1996, ) cex^KS181
Name Synonym
Secondary FlyBase IDs
	FBal0001593
References ( 10 )
Research paper	Hitier et al., 2000, Mech. Dev. 99(1-2): 93--100 no-bridge and linotte act jointly at the interhemispheric junction to build up the adult central brain of Drosophila melanogaster. [FBrf0131314] Scholz et al., 2000, Neuron 28(1): 261--271 Functional ethanol tolerance in Drosophila. [FBrf0131396] Martin et al., 1999, J. Comp. Physiol. A, Sens. Neural. Behav. Physiol. 185(3): 277--288 Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster. [FBrf0111965] Renn et al., 1999, J. Neurobiol. 41(2): 189--207 Genetic analysis of the Drosophila ellipsoid body neuropil: Organization and development of the central complex. [FBrf0111476] Varnam et al., 1996, J. Neurogenet. 11(1-2): 99--115 Larval behavior of Drosophila central complex mutants: interactions between no bridge, foraging, and chaser. [FBrf0108418] Strauss and Heisenberg, 1993, J. Neurosci. 13(5): 1852--1861 A higher control center of locomotor behavior in the Drosophila brain. [FBrf0058917]
Review	Mehren et al., 2004, Curr. Opin. Neurobiol. 14(6): 745--750 Unconventional sex: fresh approaches to courtship learning. [FBrf0180098] Ferrus and Canal, 1994, Trends Neurosci. 17(11): 479--486 The behaving brain of a fly. [FBrf0078379]
Abstract	Strauss, 1997, J. Neurogenet. 11: 201--202 The central complex controls step length: evidence from newly identified walking-impaired mutant lines of Drosophila melanogaster. [FBrf0105055] Varnam and Sokolowski, 1995, J. Neurogenet. 10(1): 61 Larval locomotion in central complex mutants. [FBrf0082743]

Allele Dmel\cexKS181

Allele Dmel\cex^KS181