Open Close
General Information
Symbol
Dmel\eya4
Species
D. melanogaster
Name
FlyBase ID
FBal0030761
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

I-element insertion into the 5' untranslated region of the type I eya transcript. The insertion duplicates 8bp of genomic sequence.

Insertion components
I{}eya4
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes have greatly reduced eyes and reduced ocelli.

eya4/eya1 flies have eyes that are between 1/4 and less than 3/4 normal size. eya4/eya3 flies may be eyeless, or may have eyes that are less than 1/4 normal size. eya4/eya3 females are fertile.

eya4/eyaE3 flies are viable, and have eyes which range from 1/2 to less than normal size. Homozygous flies have eyes which are less than 1/2 normal size. Transheterozygotes in combination with eya1, eya2, eya3, eyaE6, eyaE11, eyaE4, eyaE7, eyaD1, eyaE9 or eyaE2 have smaller eyes than normal. Transheterozygotes in combination with eyaE12, eyaE1, eyaD5, eyacli-IID, eyaE8, eyaE5, eyaE10, eyaD4, eyaZ283, eyaD2, eyaD3, eyaD6 or eyaD7 are eyeless.

Homozygotes have severely reduced eyes. eya2/eya4 heterozygous flies have 3/4 sized eyes.

Ocelli are missing, and the posterior vertical bristles of the head are truncated with frayed ends. Eyes have a variable phenotype, ranging from all eye tissue absent, with cuticle containing occasional hairs or bristles occupying the space normally occupied by the ommatidia, through streaks of red-pigmented cuticle with no eye facets present, to patches of red-pigmented cuticle occupying 10-25% of the wild-type eye area, and 10-25 facets present. Eye discs from late third instar larvae show extensive areas of dead cells. Transheterozygotes with eya1 have reduced eyes with fewer facets than normal and the facets are disorganised. The posterior vertical bristles of the head are truncated with frayed ends.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Transheterozygotes with dppd-blk and sounspecified are normal.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Eisenberg and Ryerse.

Comments
Comments

eya3 and eya4 form an intragenic complementation group that interacts with eya1 and eya2.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
clieya-4
ey-2unspecified
Name Synonyms
Secondary FlyBase IDs
  • FBal0051586
References (8)