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General Information
Symbol
Dmel\cpo1
Species
D. melanogaster
Name
FlyBase ID
FBal0030933
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
cpocp1
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion in an intron of cpo, 38bp upstream of the transcription start site (insertion site is between nucleotides 12297 and 12298 of scaffold AE003720, release 3).
Insertion of 17kb P{lacZ} at position 0 of cpo walk, between putative zeste-binding sites and putative transcription start site.
Insertion of P element at cytological position 90D, into an intron of cpo.
Insertion components
P{lArB}cpo1
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
cpoEG1/cpo1 flies have behavioural abnormalities in phototaxis, geotaxis, flight and recovery from ether. The flies are sluggish and show defects in mating vigour. cpoEG1/cpo1 and flies are more sensitive to seizures induced by a high frequency stimulus than wild-type flies; the mean seizure threshold is reduced compared to wild-type flies, to 11.1 +/- 3.7 V. The recovery period following seizure for cpoEG1/cpo1 flies is 83.2 +/- 23.8 seconds, which is considerably longer than the recovery period of wild-type flies. The firing threshold of the giant fiber in cpo1/+ and cpoEG1/cpo1 flies is not significantly different from wild type. The giant fiber-tergotrochanteral muscle (GF-TTM) response is abnormal cpoEG1/cpo1 flies; the wild-type short latency response is replaced by a longer latency response that cannot follow even moderate frequencies of stimulation. However, in response to direct electrical stimulation, the cpoEG1/cpo1 TTM is similar to wild type in latency and following frequency. The giant fiber-dorsal longitudinal muscle (GF-DLM) response in cpoEG1/cpo1 animals is normal in latency but impaired in following frequency. In response to direct electrical stimulation, the cpoEG1/cpo1 DLM is similar to wild type in latency and following frequency.
Behavioural defects in the adult.
Behavioural defects in phototaxis, geotaxis, flight response and recovery from ether anaesthesia are seen in homozygotes and in transheterozygotes with either cpol1 or cpol2. Behavioural defects in phototaxis and recovery from ether anaesthesia are seen in transheterozygotes with cpo2.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
cpo[+]/cpo1 is an enhancer of bang sensitive | dominant phenotype of jusiso7.8
Other
Phenotype Manifest In
NOT Enhanced by
NOT suppressed by
NOT Enhancer of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
cpo1 acts as a dominant enhancer of seizure susceptibility; the cpo1/+ sdaiso7.8/+ double heterozygote has a seizure threshold of 11.8 +/- 1.6 V.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
Allelic series of cpo alleles: cpolΔcp11 > cpol1 = cpol2 = cpol3 = cpol4 = cpol5 = cpol6 = cpoj4A1 = cpol8 > cpol9 > cpolΔcp12 > cpo1 = cpo2. Wild type cpo revertants have been made by Δ2-3 excision of the P-element.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)