Open Close
General Information
Symbol
Dmel\dpphr92
Species
D. melanogaster
Name
FlyBase ID
FBal0031071
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G2458553A

Reported nucleotide change:

G2947A

Amino acid change:

C587Y | dpp-PA; C587Y | dpp-PB; C587Y | dpp-PC; C587Y | dpp-PE

Reported amino acid change:

C587Y

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: C587Y.

Mutation falls in the C-terminal ligand region of the dpp protein.

Nucleotide substitution: G2947A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

dpphr92/+ mutant wings show thickened, bifurcated veins.

The hindgut of heterozygous and homozygous embryos is significantly shorter than that of wild-type embryos. In heterozygotes, the hindgut is associated with abnormally internalised anal pads. In homozygous embryos, the small intestine and rectum form normally, but the large intestine is very short.

Embryos show cuticular holes, disorganization of the head skeleton, internalization of the seventh and eighth abdominal segments and a thoracic constriction. The first and second ventral denticle belts are expanded up to the dorsal midline. The filzkorper are entirely absent.

Survival of heterozygotes is reduced if also heterozygous for certain alleles of tld.

Dominant lethality less than 50%. Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

Moderate ventralised phenotype. Rings of ventral denticle belts differentiate around the entire dorsoventral axis, almost no dorsal hairs are seen and the antennal and maxillary sense organs are missing. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference

dpp[+]/dpphr92 is a non-enhancer of visible | adult stage phenotype of Irk2UAS.cDa, Scer\GAL4da.G32

Phenotype Manifest In
Enhanced by
Statement
Reference

dpphr92 has phenotype, enhanceable by tld14

Enhancer of
Statement
Reference

dpp[+]/dpphr92 is an enhancer of wing phenotype of Irk2DN.UAS, Scer\GAL4Bx-MS1096

NOT Enhancer of
Statement
Reference

dpp[+]/dpphr92 is a non-enhancer of wing vein phenotype of Irk2UAS.cDa, Scer\GAL4Bx-MS1096

Suppressor of
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The increased number of spectrosome-containing cells in germaria characteristic for adult females expressing Cul2GD8913 RNAi under the control of the Scer\GAL4ptc.PU can be partially rescued by combination with either dpphr92, dpphr56 or tkv7 in a heterozygous state or by knocking-down dpp by co-expression of either dppJF01090 or dppJF01091 RNAi.

One copy of dpphr92 enhances the wing defects seen when Irk2DN.Scer\UAS is expressed under the control of Scer\GAL4Bx-MS1096. 84% of wings from female flies expressing the P{UAS-Irk2.DN}5.2 insertion line display defects, with 29% of these considered to be severe. When the stronger P{UAS-Irk2.DN}5.1 insertion line is expressed 97% of wings from female flies display severe defects.

One copy of dpphr92 does not enhance the wing vein defects seen when Irk2Scer\UAS.cDa is expressed under the control of Scer\GAL4Bx-MS1096.

dpphr92/+ partially suppresses the Su(var)3-3ΔN mutant supernumerary germline cell phenotype resulting in an increased number of germline cysts with branched fusomes and maturing egg chambers.

dpphr92/+ ; Ack86/Ack86 embryos show dorsal closure defects at a relatively low frequency, but which is significantly higher than the frequency seen in either dpphr92/+ or Ack86/Ack86 single mutant embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dppe87 < dppe90 < dpphr56 < dpphr4 < dpphr92 < dpphr27 < dpphr93 < dppH94 < dppH95 < dppH96 = dppH91 = dppH46.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (21)