Allele Dmel\ea^161.13

General Information
Symbol	Dmel\ea^161.13	Species	D. melanogaster
Name		FlyBase ID	FBal0031156
Feature type	allele	Associated gene	Dmel\ea

Map ( GBrowse )
Allele class	gain of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	gain of function allele (Terracol and Lengyel, 1994)
Mutagen	ethyl methanesulfonate (Terracol and Lengyel, 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:11,156,015..11,156,015 evidence=experimental na_change=G11156015A pr_change=G371R\|ea-PA reported_na_change=G5564A reported_pr_change=G371R (Jin and Anderson, 1990)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: G1314A. (Jin and Anderson, 1990) Amino acid replacement: G371R. (Jin and Anderson, 1990)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| dominant \| maternal effect (Jin and Anderson, 1990) lethal \| embryonic stage \| recessive (George and Terracol, 1997)
Phenotype Manifest In
	dorsal closure embryo (Szuplewski and Terracol, 2001) embryonic/first instar larval cuticle \| maternal effect (Jin and Anderson, 1990) extended germ band embryo (George and Terracol, 1997) head (George and Terracol, 1997)
Detailed Description
	Statement Reference 62% of embryos derived from ea^161.13/+ females crossed to wild-type males die. 100% of the dead embryos are very weakly ventralised (head involution does not occur and some embryos have a tail up phenotype, Filzkorper are normal). (Szuplewski and Terracol, 2001) 62% embryos from heterozygous females crossed to wild type males die and are weakly ventralised. Embryos show failure of head involution and 25% have a 'tail-up' phenotype due to an incomplete retraction of the germ band. (George and Terracol, 1997) Weakly ventralised embryos. When maternal or zygotic tkv levels are reduced most of the embryos die and show an increased level of ventralisation. (Terracol and Lengyel, 1994) Embryos weakly ventralized. (Jin and Anderson, 1990)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference ea^161.13 has phenotype, enhanceable by put¹³⁵ (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by shn¹ (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri¹ (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri² (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^5R4.11 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^5R5.7 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^5R5.24 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^5R7.2 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^5R8.4 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^k03801 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^k05901 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^k09602 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^k09713 (George and Terracol, 1997) ea^161.13 has phenotype, enhanceable by vri^k11805 (George and Terracol, 1997) ea^161.13 has stage 14 embryo phenotype, enhanceable by cype[+]/cype⁰³⁷⁷¹ (Szuplewski and Terracol, 2001)
Other
Statement Reference cype[+]/cype⁰³⁷⁷¹, ea^161.13 has denticle belt phenotype (Szuplewski and Terracol, 2001) cype[+]/cype⁰³⁷⁷¹, ea^161.13 has embryonic head phenotype (Szuplewski and Terracol, 2001) cype[+]/cype⁰³⁷⁷¹, ea^161.13 has embryonic segment phenotype (Szuplewski and Terracol, 2001) cype[+]/cype⁰³⁷⁷¹, ea^161.13 has embryonic thorax phenotype (Szuplewski and Terracol, 2001) cype[+]/cype⁰³⁷⁷¹, ea^161.13 has filzkorper phenotype (Szuplewski and Terracol, 2001) cype⁰³⁷⁷¹, ea^161.13 has denticle belt phenotype (Szuplewski and Terracol, 2001) cype⁰³⁷⁷¹, ea^161.13 has embryonic head phenotype (Szuplewski and Terracol, 2001) cype⁰³⁷⁷¹, ea^161.13 has embryonic segment phenotype (Szuplewski and Terracol, 2001) cype⁰³⁷⁷¹, ea^161.13 has embryonic thorax phenotype (Szuplewski and Terracol, 2001) cype⁰³⁷⁷¹, ea^161.13 has filzkorper phenotype (Szuplewski and Terracol, 2001)
Additional Comments
Genetic Interactions
Statement Reference 99% of embryos derived from cype⁰³⁷⁷¹/+ ; ea^161.13/+ females crossed to wild-type males die with a ventralised phenotype. 10% are very weakly ventralised (head involution does not occur and some embryos have a tail up phenotype, Filzkorper are normal), 80% are weakly ventralised (the head is not involuted, the posterior segments are internalised and the Filzkorper are disorganised) and 10% are moderately ventralised (the ventral denticle belt is extended laterally, Filzkorper are reduced and disorganised, the head is not involuted and the head and thorax are extended and convoluted). (Szuplewski and Terracol, 2001) When in combination with vri^k05901, vri^k09713, vri^5R5.7, vri^5R5.7 and vri^5R5.7 all embryos die. When in combination with other vri alleles, Df(2L)tkv2, shn¹ and put¹³⁵ lethality is greatly increased and embryos are more strongly ventralised. (George and Terracol, 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ea^161.13 (Jin and Anderson, 1990)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Szuplewski and Terracol, 2001, Genetics 158(4): 1629--1643 The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. [FBrf0138407] George and Terracol, 1997, Genetics 146(4): 1345--1363 The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. [FBrf0094777] Terracol and Lengyel, 1994, Genetics 138(1): 165--178 The thick veins gene of Drosophila is required for dorsoventral polarity of the embryo. [FBrf0076541] Jin and Anderson, 1990, Cell 60: 873--881 Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. [FBrf0051391]

Allele Dmel\ea161.13

Allele Dmel\ea^161.13