FB2025_01 , released February 20, 2025
Allele: Dmel\esgL2
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General Information
Symbol
Dmel\esgL2
Species
D. melanogaster
Name
FlyBase ID
FBal0031212
Feature type
allele
Associated gene
Dmel\esg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Fuse et al., 1994, Hayashi et al., 1993)
Mutagen
Delta2-3 transposase
(Hayashi et al., 1993)
P-element activity
(Ashburner et al., 1999.10.12)
Progenitor genotype
esgP2
(Hayashi et al., 1993)
Cytology
Description

Small deletion within the coding region.

(Fuse et al., 1994)

Part of the esg transcription unit deleted (S. Hayashi, unpublished observations).

(Hayashi et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Progeny from esgL2 mutant somatic stem cells in the testis do not contribute to the hub at the same frequency as wild-type cells.

      (Voog et al., 2008)

      esgL2 mutant embryos develop variable muscle pattern defects that include the absence of lateral transverse muscles, loss of muscle fibers, and abnormally shaped muscles. The pattern of muscle attachment sites appears normal.

      (Staudt et al., 2005)

      Heterozygotes with esgGW2 are viable with reduced abdominal cuticle and bristles. Introduction of P{HS-esg.F} and multiple heat shocks increases the number of bristles.

      (Fuse et al., 1994)

      Many heteroallelic combinations studied. In cases where flies die as pharate adults, defects evident in abdominal sternites/tergites. In cases where flies are viable, they show held out wing phenotype, and may have some sternites and tergites deleted.

      (Hayashi et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      esgL2
      (Antonello et al., 2015, Voog et al., 2014, Voog et al., 2008, Staudt et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)