Open Close
General Information
Symbol
Dmel\fafB3
Species
D. melanogaster
Name
FlyBase ID
FBal0031239
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C31778676T
Reported nucleotide change:
C?T
Amino acid change:
Q71term | faf-PA; Q71term | faf-PC; Q71term | faf-PD; Q71term | faf-PE; Q71term | faf-PG; Q71term | faf-PH; Q71term | faf-PI
Reported amino acid change:
Q71term
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid replacement: Q71term.
Nucleotide substitution: C?T.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
ameliorates  epilepsy
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Only 27% of the expected number of fafFO8/fafB3 zygotic mutants survive. The embryos have a ventralised cuticle with dorsally extended denticles and an ectopic denticle belt replacing the Filzkorper. fafB3/Df(3R)faf-BP embryos have a ventralised cuticle with herniated head, dorsally extended denticles and an misplaced Filzkorper. Embryos derived from fafB3/fafB5 females mated to wild-type males show almost complete ventralisation of the cuticle. The rudimentary cuticle contains one anterior denticle belt that fully encircles the embryo.
Only 7% of embryos derived from fafB3 females form pole cells, and these embryos have far fewer pole cells than in wild-type embryos. The pole cells that form show a variety of migration defects, failing to migrate into the abdomen and instead spreading out over the embryo surface. Many of the embryos fail to undergo or undergo abnormal nuclear divisions; 45% of embryos derived from fafB3 females are unfertilised (one nucleus), 12% are arrested at a two nuclear stage and 40% are multinucleated, but usually have irregularly arranged nuclei.
Eyes roughened due to abnormalities in the hexagonal facet array: most facets include 1-3 extra outer photoreceptor cells which are probably mystery cells. Ovaries of homozygous females are normal in appearance but the embryos produced never form syncytial blastoderm and all fail to hatch.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
faf[+]/fafB3 is a suppressor of bang sensitive | dominant phenotype of pksple-1
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The presence of fafB3/+ rescues the bang-sensitive phenotype of pksple-1/+ mutants.
Embryos derived from Med8/+ females mated to males heterozygous for fafB3 show semi-lethality.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (1)
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)