Open Close
General Information
Symbol
Dmel\fafB4
Species
D. melanogaster
Name
FlyBase ID
FBal0031240
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:
Amino acid residue F279 is replaced by NPNNLL due to deletion of a TTT codon and insertion of 18bp (AATCCCAACAATCTACTG).
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Amino acid residue F279 is replaced by NPNNLL due to deletion of a TTT codon and insertion of 18bp (AATCCCAACAATCTACTG).
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Embryos derived from fafB4/fafB5 females mated to wild-type males show modest ventralisation of the cuticle, with a herniated head, poorly developed Filzkorper and slightly extended ventral cuticles. Embryos derived from fafB4/fafB6 females mated to wild-type males show ventralisation of the cuticle, with a herniated head, defective Filzkorper and denticle belts that extend throughout the ventral half of the cuticle. Embryos derived from fafB4/fafFO8 females mated to wild-type males show significant ventralisation of the cuticle, with a herniated head, defective Filzkorper, malformed dorsal cuticle and denticle belts that extend well into the dorsal half of the embryo. Embryos derived from fafB4/fafBX3 females mated to wild-type males show significant ventralisation of the cuticle, with a herniated head, defective Filzkorper, malformed dorsal cuticle and extended denticle belts.
Mutation has no effect on rhohs.sev rough eye phenotype.
Eyes roughened due to abnormalities in the hexagonal facet array: but only 1% of facets are affected. Females are fertile.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Embryos derived from Med8/+ females mated to males heterozygous for fafB4 show semi-lethality. The embryos have a ventralised cuticle. Embryos derived from fafB4/+ females mated to Med8/+ males have a wild-type cuticle.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)