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General Information
Symbol
Dmel\fogS4
Species
D. melanogaster
Name
FlyBase ID
FBal0031279
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    The salivary gland primordia of fogS4 homozygous stage 11 embryos frequently exhibit an abnormal ingression furrow along their edge, as compared to controls.

    fogS4 hemizygous late embryos display severe cuticle defects, and a severe posterior-ventral cuticle hole phenotype, as compared to controls.

    fogS4/Y embryos exhibit defects in internalization of mesodermal and posterior midgut cells, which results in changes to the morphology of the ventral midline.

    The posterior midgut is not internalised in mutant embryos, and instead develops on the exterior of the embryo. Stage 13 mutant male embryos have a normal number of somatic gonadal precursor cells. Mutant male first instar larvae show a 70% reduction in the number of hub cells in the gonad compared to controls.

    Despite blocked gastrulation movements, all tissues except the posterior midgut epithelium develop normally. Cells of the mesoderm and the anterior endoderm are eventually internalized. Two normally sized bands of visceral mesoderm are formed. The anterior endoderm usually reaches its normal position, becomes attached to the visceral mesoderm, and forms a normal epithelium. The posterior endoderm remains on the surface of the embryo. Not contacting the visceral mesoderm, posterior endoderm cells remain mesenchymal.

    Suppression of tor13D embryos: increase in proportion of embryos that formed cuticle with denticles and decrease in proportion of embryos that formed empty sacs.

    External Data
    Interactions
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    Phenotypic Class
    Enhancer of
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The severe cuticle defects exhibited by fogS4 hemizygous zygotic late embryos are ameliorated by a torrv66 homozygous maternal genotype, leading to fully penetrant "terminal class mutant" and posterior-ventral cuticle hole phenotypes.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (2)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (9)