FlyBase Allele Report: Dmel\chico[1]

While chico¹/chico^KG00032 females produce similar amount of eggs as controls, ovaries show decreased mtDNA replication in region 2B and 3 cysts, and eggs show severely decreased levels of mtDNA.

(Wang et al., 2019)

chico¹ mutant flies show decreased learning index in a behavioral olfactory learning assay (measuring 3 min memory) compared to controls.

chico¹ homozygotes display decreased number of Kenyon cell in the brain compared to controls.

(Naganos et al., 2016)

chico¹ mutant salivary gland cells exhibit wild-type endoplasmic reticulum and Golgi organisation.

(Charroux and Royet, 2014)

chico¹/+ mutants do not exhibit any significant difference in the number of dopaminergic neurons in newly eclosed adult males, and these flies do not display any significant reduction in climbing ability.

(Knight et al., 2014)

Homozygous and chico¹/chico^flp147E adults show normal odour and electric shock reactivity.

Homozygous and chico¹/chico^flp147E adults show significant impairment in 3 minute, 1 hour and 3 hour memory after olfactory aversive conditioning. Analysis using a short-duration training protocol indicates that the defect appears to be in the initial learning, since after normalising 3 minute memory in chico¹ and wild-type flies, subsequent memory decay is indistinguishable in the two genotypes.

The brains of homozygous flies are significantly smaller than normal, with a significant reduction in the number of Kenyon cells and in the size of the mushroom bodies.

(Naganos et al., 2012)

Mutant flies have a significantly reduced body size compared to controls. Wing cell size is reduced compared to controls.

(Pallares-Cartes et al., 2012)

Heterozygous females show an extension of median lifespan compared to wild-type controls. These females show accelerated accumulation of cytosolic hydrogen peroxide in the gut compared to wild-type controls.

Heterozygous males do not show an extension of median lifespan compared to wild-type controls. These males show a delayed accumulation of cytosolic hydrogen peroxide in the gut compared to wild-type controls.

(Albrecht et al., 2011)

Homozygous chico¹ mutant adult flies have a reduced body weight compared to heterozygous controls. Wing area is also reduced compared to controls.

Lipid content is increased in homozygous chico¹ mutant flies compared to controls. Carbohydrate content is similar to controls.

Homozygous chico¹ mutant flies exhibit defective electroretinogram (ERG) readings.

Cholinesterase activity is significantly reduced in homozygous chico¹ mutant flies compared to controls.

(Murillo-Maldonado et al., 2011)

The frequency of proliferating cells in the intestine of aging chico¹ homozygotes is significantly lower than that of age-matched controls.

(Biteau et al., 2010)

Heterozygous flies show increased resistance to dry starvation compared to control flies.

(Hull-Thompson et al., 2009)

The length of the dorsal hemisegments along the antero-posterior axis in chico¹ mutant larvae is only 10% of that of wild-types.

(Parrish et al., 2009)

In a fed state, chico¹ flies are anoxia tolerant (heterozygotes are not).

(Vigne et al., 2009)

chico¹/chico^flp147E flies have elevated levels of lipids compared to control flies.

(Werz et al., 2009)

Heterozygous ovaries transplanted into homozygous females usually show a robust vitellogenic response, with vitellogenic oocytes spanning the entire range of stage 8 to mature stage 14 eggs being seen in the transplanted ovaries. In all cases, the oocytes of the homozygous host female terminate development at the previtellogenic stage 7.

Homozygous ovaries transplanted into heterozygous or wild-type females fail to develop oocytes beyond stage 7, even though the host ovaries become fully vitellogenic in each recipient female.

Methoprene does not stimulate vitellogenesis or egg production in homozygous females.

On day 1 post-eclosion, homozygous females contain an average of 11.2 nurse cells per egg chamber, and on day 4 they have an average of 14.8 nurse cells per egg chamber (a statistically significant difference).

(Richard et al., 2005)

chico¹ mutants show a reduction in wing size compared to wild-type controls. However, this phenotype is not temperature sensitive as chico¹ flies raised at 25^oC show a similar decrease in wing area compared to chico¹ flies raised at 18^oC to the decrease in wing area observed for control flies at these two temperatures.

Males that carry chico¹ Minute clones throughout one side of the genitals and are heterozygous for chico¹ on the other side show smaller genital arches on the homozygous clone side than on the heterozygous side. The difference in size is 16%. Maxillary palps consisting of chico¹ homozygous clones are 45% smaller than paired palps on the same male.

(Shingleton et al., 2005)

chico¹ homozygous adults are abnormally small and have reduced numbers of ommatidia per eye.

(Wittwer et al., 2005)

chico¹ homozygous mutants are small, weighing on average 44% of the mass of wild-types. Mean oxygen consumption is not significantly higher than in wild-type flies. Mass-specific resting heat production is the same in chico¹ mutants as wild-type flies. Dietary-restriction of chico¹ mutants has no effect on resting heat production. While the body mass of wild-type flies fed on an energy restricted medium is reduced, chico¹ mutants show no decrease in body mass.

(Hulbert et al., 2004)

chico¹ flies are small and live ~50% longer than wild-type flies. These flies have low rates of pacing-induced heart failure and arrest, and their heart beat frequency does not increase with age, compared to wild-type flies. chico¹/+ flies have lifespans that are longer than wild-type flies, but shorter than chico¹ homozygotes. Like wild-type flies, these chico¹/+ flies experience stress-induced heart failure and their heart beat frequency decreases with age. There is no difference between male or female flies for any of the heart functions tested in homozygous or heterozygous chico¹ flies.

(Wessells et al., 2004)

chico¹/chico^flp147E flies show lower body weight, fewer ommatidia, smaller wings, fewer cells per wing and smaller wing cell area than wild type.

(Junger et al., 2003)

Photoreceptor cell projection patterns are indistinguishable from wild type in homozygous larvae and in mosaic larvae in which homozygous clones have been induced in the eye. The pattern of R7 and R8 projections in the medulla is similar to wild type in mosaic adults in which homozygous clones have been induced in the eye. Heterozygotes have normal photoreceptor cell projections in the medulla.

(Song et al., 2003)

The relation between life-span and food concentration is right-shifted in chico¹ females compared to controls. Control and chico¹ females show similar peak life-spans under dietary restriction, but chico¹ females show a peak in mean lifespan at a food concentration 0.8 times that of normal, while control females show a peak in mean lifespan at a food concentration 0.65 times that of normal.

(Clancy et al., 2002)

chico¹ adults are resistant to starvation conditions compared to wild type.

(Oldham et al., 2002)

Homozygous adults are dwarf in size. Homozygous females show an increase of median and maximum life-span of up to 48 and 41% respectively compared to controls. Homozygous males are slightly short-lived. Heterozygous females and males show an increase in median life-span of up to 36 and 13% respectively. Heterozygous females have reduced fecundity and homozygotes are almost sterile. Mutant flies show no resistance to heat stress at 37^oC. Slight resistance to oxidative stress (methyl viologen) is seen in heterozygotes but not in homozygotes. Heterozygotes and homozygotes show some resistance to starvation.

(Clancy et al., 2001)

The chico¹ mutation partially impaired the ability of follicle cells to proliferate faster in the presence of abundant nutrients. Egg chambers do not develop beyond vitellogenic stages in homozygotes, even in the presence of abundant food.

(Drummond-Barbosa and Spradling, 2001)

chico¹ flies do not show unexpanded wings, are not dark and do not show male sterility.

(Riesgo-Escovar, 2001.2.7)

Homozygous clones are not visible in the adult eye because they are out-competed by heterozygous cells.

(Wittwer et al., 2001)

Homozygosity for chico¹ causes semilethality and an overall delay in development. Flies eclose 2-3 days after their heterozygous siblings. In non-crowded culture conditions, homozygous mutant mothers can produce few viable progeny lacking both maternal and zygotic chico function. Homozygotes have a drastic weight reduction (65% in females, 55% in males) compared to wild-type. Body size reduction is observed at all developmental stages but does not alter the overall proportions of the flies. Homozygous clones in the eye produce morphologically normal ommatidia, except that they are more than 50% smaller than wild-type. Otherwise normal ommatidia with both smaller mutant and larger wild-type photoreceptors are observed at the edges of clones, indicating that chico acts cell autonomously. Autonomy of cell size control is also observed in mutant clones in the wing. Selective removal of chico¹ function in the eye imaginal disc cells generates flies with a strongly reduced head capsule and reduced eyes, whereas the proboscis and the rest of the body are of wild type size. Homozygous mutant clones in the adult eye are rarer, more variable in size and on average smaller than their wild-type sister clones. Clones are more frequently observed in the anterior half of the eye around the equator. In the eye disc, clones are also more variable in size and on average smaller than their wild-type sister clones. TUNEL analysis shows no increase in apoptotic cells in homozygous clones. Clones produced in a Minute background do not reveal enhanced apoptosis compared to wild type clones, or any increase in morphological signs of programmed cell death, in either the imaginal discs or the adult eye. No significant difference is seen in the apoptotic sub-G1 fraction of homozygous mutant cells compared to heterozygous cells.

(Bohni et al., 1999)

Mutant flies develop slower than sibling controls and have a reduced body size. chico mutant cells differentiate normally but are significantly reduced in size.

(Riesgo-Escovar et al., 1998)

male fertility poor female-sterile

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

chico^flp147E/chico¹ has decreased cell size phenotype, enhanceable by foxo²⁵/foxo²¹

(Junger et al., 2003)

NOT Enhanced by

Statement

Reference

chico¹ has long lived phenotype, non-enhanceable by Scer\GAL4^{Act5C.Switch.PR}/Atg12^RNAi.UAS

(Bjedov et al., 2020)

chico¹ has long lived phenotype, non-enhanceable by csw⁶

(Ruzzi et al., 2020)

chico¹ has long lived | dominant phenotype, non-enhanceable by aop^ACT.UAS/Scer\GAL4^Switch1.106

(Slack et al., 2015)

chico^flp147E/chico¹ has decreased body size phenotype, non-enhanceable by srl^KG08646

(Tiefenböck et al., 2010)

chico¹ has long lived | dominant phenotype, non-enhanceable by ovo^D1

(Clancy et al., 2001)

Suppressed by

Statement

Reference

chico¹ has long lived phenotype, suppressible by Scer\GAL4^{Act5C.Switch.PR}/Atg5^RNAi.UAS

(Bjedov et al., 2020)

chico¹ has abnormal learning | adult stage phenotype, suppressible by Scer\GAL4^ey-OK107/Adcy1^UAS.cUa

(Naganos et al., 2016)

chico¹ has abnormal learning | adult stage phenotype, suppressible by Adcy1^UAS.cUa/Scer\GAL4^{Mef2.247.Switch}

(Naganos et al., 2016)

chico¹ has long lived | dominant phenotype, suppressible by Ras85D^V12.cUa.UAS/Scer\GAL4^da.Switch.PT

(Slack et al., 2015)

chico¹ has female sterile phenotype, suppressible by PRAS40^KO

(Pallares-Cartes et al., 2012)

chico¹, foxo^Δ94 has lethal phenotype, suppressible by foxo^UASp.cSa/Scer\GAL4^da.G32

(Slack et al., 2011)

chico¹ has decreased body size | adult stage phenotype, suppressible by B4^susi-1

(Wittwer et al., 2005)

chico^flp147E/chico¹ has decreased cell number phenotype, suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

chico^flp147E/chico¹ has decreased cell number phenotype, suppressible by foxo²⁵/foxo²¹

(Junger et al., 2003)

chico^flp147E/chico¹ has visible phenotype, suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

chico^flp147E/chico¹ has visible phenotype, suppressible by foxo²⁵/foxo²¹

(Junger et al., 2003)

chico^flp147E/chico¹ has decreased body size phenotype, suppressible | partially by foxo²⁵/foxo²¹

(Junger et al., 2003)

NOT suppressed by

Statement

Reference

chico¹ has long lived phenotype, non-suppressible by Scer\GAL4^{Act5C.Switch.PR}/Atg12^RNAi.UAS

(Bjedov et al., 2020)

chico¹ has long lived phenotype, non-suppressible by csw⁶

(Ruzzi et al., 2020)

chico¹ has abnormal neuroanatomy phenotype, non-suppressible by Scer\GAL4^ey-OK107/Adcy1^UAS.cUa

(Naganos et al., 2016)

chico¹ has decreased body size phenotype, non-suppressible by PRAS40^KO

(Pallares-Cartes et al., 2012)

chico¹ has decreased cell size phenotype, non-suppressible by PRAS40^KO

(Pallares-Cartes et al., 2012)

chico^flp147E/chico¹ has decreased cell size phenotype, non-suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

NOT Enhancer of

Statement

Reference

chico¹ is a non-enhancer of long lived phenotype of csw⁶

(Ruzzi et al., 2020)

chico¹/chico[+] is a non-enhancer of long lived | RU486 conditional phenotype of Scer\GAL4^Switch1.106, aop^ACT.UAS

(Slack et al., 2015)

chico¹/chico[+] is a non-enhancer of abnormal size | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

chico¹ is a non-enhancer of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

chico¹ is a non-enhancer of long lived | dominant phenotype of ovo^D1

(Clancy et al., 2001)

Suppressor of

Statement

Reference

chico¹/chico[+] is a suppressor of decreased cell number | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF

(Knight et al., 2014)

chico¹/chico[+] is a suppressor of abnormal neuroanatomy | adult stage | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF

(Knight et al., 2014)

chico¹/chico[+] is a suppressor of increased cell number | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

chico¹/chico[+] is a suppressor of abnormal size | adult stage phenotype of Pten^UAS.cHa, Scer\GAL4^ey.PH

(Huang et al., 1999)

NOT Suppressor of

Statement

Reference

chico¹ is a non-suppressor of long lived phenotype of csw⁶

(Ruzzi et al., 2020)

chico¹/chico[+] is a non-suppressor of short lived | RU486 conditional phenotype of Ras85D^V12.cUa.UAS, Scer\GAL4^da.Switch.PT

(Slack et al., 2015)

chico¹/chico[+] is a non-suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^da.Switch.PT, aop^HMS01256

(Slack et al., 2015)

chico¹/chico[+] is a non-suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^da.Switch.PT, pnt^P1.UAS

(Slack et al., 2015)

chico¹/chico[+] is a non-suppressor of short lived phenotype of foxo^Δ94

(Slack et al., 2015)

chico¹/chico[+] is a non-suppressor of abnormal locomotor behavior | adult stage phenotype of Pgi^EY09730

(Knight et al., 2014)

chico¹/chico[+] is a non-suppressor of abnormal starvation stress response | adult stage | RU486 conditional phenotype of Scer\GAL4^Switch1.106, Sirt1^GD11580

(Banerjee et al., 2012)

chico¹/chico[+] is a non-suppressor of increased body size phenotype of Scer\GAL4^29BD, dally^{sec.UAS.Tag:MYC}

(Takeo et al., 2005)

chico¹ is a non-suppressor of lethal | pupal stage phenotype of Csk^j1D8/Csk^S030003

(Read et al., 2004)

chico¹ is a non-suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

Other

Statement

Reference

chico¹, mir-277^Ubi-p63E.PZ has lethal phenotype

(Esslinger et al., 2013)

PRAS40^KO, chico¹ has female fertile phenotype

(Pallares-Cartes et al., 2012)

chico¹, foxo^Δ94 has lethal phenotype

(Slack et al., 2011)

Df(2L)Exel6026/+, Lnk^6S2/Lnk^4Q3, chico¹ has viable phenotype

(Werz et al., 2009)

Lnk^6S2/Lnk^4Q3, chico^flp147E/chico¹ has lethal phenotype

(Werz et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

chico^flp147E/chico¹ has ommatidium phenotype, enhanceable by foxo²⁵/foxo²¹

(Junger et al., 2003)

Suppressed by

Statement

Reference

chico¹ has ommatidium phenotype, suppressible by B4^susi-1

(Wittwer et al., 2005)

chico¹ has ommatidium phenotype, suppressible by B4⁰⁵³³⁷

(Wittwer et al., 2005)

chico^flp147E/chico¹ has ommatidium phenotype, suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

chico^flp147E/chico¹ has ommatidium phenotype, suppressible by foxo²⁵/foxo²¹

(Junger et al., 2003)

chico^flp147E/chico¹ has wing phenotype, suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

chico^flp147E/chico¹ has wing phenotype, suppressible by foxo²⁵/foxo²¹

(Junger et al., 2003)

NOT suppressed by

Statement

Reference

chico¹ has Kenyon cell phenotype, non-suppressible by Scer\GAL4^ey-OK107/Adcy1^UAS.cUa

(Naganos et al., 2016)

chico^flp147E/chico¹ has ommatidium phenotype, non-suppressible by foxo²¹/foxo[+]

(Junger et al., 2003)

Enhancer of

Statement

Reference

chico¹/chico[+] is an enhancer of eye phenotype of Pten^UAS.cHa, Scer\GAL4^ey.PH

(Huang et al., 1999)

chico¹/chico[+] is an enhancer of ommatidium phenotype of Pten^UAS.cHa, Scer\GAL4^ey.PH

(Huang et al., 1999)

chico¹/chico[+] is an enhancer of eye disc phenotype of Pten^UAS.cHa, Scer\GAL4^ey.PH

(Huang et al., 1999)

NOT Enhancer of

Statement

Reference

chico¹/chico[+] is a non-enhancer of wing blade phenotype of sl²

(Murillo-Maldonado et al., 2011)

chico¹/chico[+] is a non-enhancer of wing vein | ectopic phenotype of sl²

(Murillo-Maldonado et al., 2011)

chico¹ is a non-enhancer of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Suppressor of

Statement

Reference

chico¹/chico[+] is a suppressor of dopaminergic neuron | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF

(Knight et al., 2014)

chico¹/chico[+] is a suppressor of photoreceptor cell R7 | adult stage phenotype of sl²

(Murillo-Maldonado et al., 2011)

NOT Suppressor of

Statement

Reference

chico¹/chico[+] is a non-suppressor of pupa phenotype of Scer\GAL4^29BD, dally^{sec.UAS.Tag:MYC}

(Takeo et al., 2005)

chico¹/chico[+] is a non-suppressor of wing phenotype of Scer\GAL4^29BD, dally^{sec.UAS.Tag:MYC}

(Takeo et al., 2005)

chico¹ is a non-suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The decreased learning index in a behavioral olfactory learning assay (measuring 3 min memory) observed in chico¹ mutant adults is restored to wild-type level by expression of rut^Scer\UAS.cUa under the control of Scer\GAL4^ey-OK107 and significantly increased by expression under the Scer\GAL4^{Mef2.247.Switch} driver in animals fed RU486 (to activate expression) compared to controls.

The decreased number of Kenyon cells seen in chico¹ homozygote brains cannot be restored by expression of rut^Scer\UAS.cUa under the control of Scer\GAL4^ey-OK107 in the mutant background.

(Naganos et al., 2016)

chico¹/+ fails to suppress the climbing defects seen in Pgi^EY09730/+ mutants.

(Knight et al., 2014)

chico¹/chico¹ ; mir-277^Ubi-p63E.PZ results in synthetic lethality.

(Esslinger et al., 2013)

The reduced survival upon starvation characteristic for flies expressing Sirt1^GD11580 under the control of Scer\GAL4^Switch1.106 (and keeping the flies on medium containing RU486 to induce the expression) cannot be suppressed by combination with a single copy of chico¹ (even though without the induction of Sirt1^GD11580 expression by RU486 the Sirt1^GD11580;Scer\GAL4[Switch1.106],chico¹/+ flies live longer than the uninduced Sirt1^GD11580;Scer\GAL4^Switch1.106-only flies).

(Banerjee et al., 2012)

PRAS40^KO completely rescues the sterility of chico¹ females, but does not suppress the reduced body and wing cell size of chico¹ flies.

(Pallares-Cartes et al., 2012)

One copy of chico¹ does not enhance the reduction in wing blade area seen in homozygous sl² males.

One copy of chico¹ does not enhance the ectopic wing vein phenotype seen in sl² homozygotes.

One copy of chico¹ partially suppresses the percentage of sl² mutant ommatidia that contain extra R7 photoreceptors.

(Murillo-Maldonado et al., 2011)

Expression of NLaz^{Scer\UAS.cHTa} under the control of Scer\GAL4^ppl.PP can not further increase the starvation resistance of chico¹/+ flies.

(Hull-Thompson et al., 2009)

Dg³²³/chico¹ double heterozygous mutant third instar larval eye discs do not show disrupted axon targeting from photoreceptor neurons to the brain optic lobes.

(Shcherbata et al., 2007)

chico¹/+; dally^{sec.Scer\UAS.T:Hsap\MYC}/Scer\GAL4^29BD pupae show the same large pupae and disordered wing patterning phenotype as wild-type animals expressing dally^{sec.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^29BD.

(Takeo et al., 2005)

The small body size and reduced numbers of ommatidia seen in chico¹ homozygous adults are partially suppressed by B4^susi-1/B4^susi-1. The eye phenotype is also partially suppressed by B4⁰⁵³³⁷/B4⁰⁵³³⁷

(Wittwer et al., 2005)

Homozygous chico;foxo double mutants have more, and even slightly smaller, cells than homozygous chico single mutants.

(Junger et al., 2003)

No obvious defects in photoreceptor axon projections in the medulla are seen in chico¹/+ ; InR^ex15/+ double heterozygous adults.

(Song et al., 2003)

ovo^D1 chico¹ double heterozygotes live as long as chico¹/+ single heterozygotes and significantly longer than ovo^D1/+ single heterozygotes.

(Clancy et al., 2001)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF in chico¹/+ mutants does not lead to any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but chico¹/+ suppresses the dopaminergic neuron loss seen in 20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF.

(Knight et al., 2014)

Complementation and Rescue Data

Rescued by

chico¹ is rescued by chico^+t5.6

(Slack et al., 2015)

chico¹ is rescued by chico^UAS.cNa/Scer\GAL4^elav.PLu

(Naganos et al., 2012)

chico¹ is rescued by Scer\GAL4^c309/chico^UAS.cNa

(Naganos et al., 2012)

chico¹ is rescued by chico^PTBmut

(Oldham et al., 2002)

chico¹ is rescued by chico^Drkmut

(Oldham et al., 2002)

chico¹ is rescued by chico^+t8

(Oldham et al., 2002)

chico¹ is rescued by chico^+t8

(Clancy et al., 2001)

chico¹ is rescued by chico^+t8

(Bohni et al., 1999)

Partially rescued by

chico¹ is partially rescued by chico^Grb2mutant

(Slack et al., 2015)

chico¹ is partially rescued by Scer\GAL4^ey-OK107/chico^UAS.cNa

(Naganos et al., 2012)

Not rescued by

chico¹ is not rescued by chico^PI3Kmutant

(Slack et al., 2015)

chico¹ is not rescued by Scer\GAL4^{elav.Switch.PO}/chico^UAS.cNa

(Naganos et al., 2012)

chico¹ is not rescued by chico^UAS.cNa/Scer\GAL4^GH146

(Naganos et al., 2012)

chico¹ is not rescued by chico^PI3Kmut

(Oldham et al., 2002)

chico¹ is not rescued by chico^PHmut

(Oldham et al., 2002)

Comments

Expression of chico^+t5.6 fully restores several phenotypic defects associated with chico¹, including developmental delay, reduced growth, female sterility and increased glycogen and lipid storage.

Expression of chico^+t5.6 restores the increased lifespan seen in chico¹ heterozygotes to that of wild type flies.

Expression of chico^Grb2mutant fully restores several phenotypic defects associated with chico¹, including developmental delay, reduced growth, female sterility and increased glycogen and lipid storage.

Expression of chico^Grb2mutant is unable to restores the increased lifespan seen in chico¹ heterozygotes to that of wild type flies.

Expression of chico^Grb2mutant does not rescue the phenotypic defects associated with chico¹.

Expression of chico^Grb2mutant is unable to restores the increased lifespan seen in chico¹ heterozygotes to that of wild type flies.

(Slack et al., 2015)

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^elav.PLu rescues the defects in 1 hour memory seen after olfactory aversive conditioning in chico¹ adults.

Expression of chico^Scer\UAS.cNa limited to the adult stage (driven by Scer\GAL4^{elav.Switch.PO} in the presence of RU486) does not rescue the defects in 1 hour memory seen after olfactory aversive conditioning in chico¹ adults.

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^ey-OK107 rescues the number of Kenyon cells and partially rescues reduced mushroom body size in chico¹ adults. Olfactory learning is rescued in these flies.

Expression of chico^Scer\UAS.cNa under the control of Scer\GAL4^c309, but not under the control of Scer\GAL4^GH146, rescues olfactory learning in chico¹ adults.

(Naganos et al., 2012)

chico^+t8 significantly reduces the extended life-span seen in chico¹ heterozygous males and females.

(Clancy et al., 2001)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10738

cn¹ P{ry11}chico¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Designation as "flp^ry4" was a symbol misassignment.

(Spradling, 1990.8.1)

Complements: flp^hd.

(Riesgo-Escovar, 2001.2.7)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

Chico¹

(Luo et al., 2020)

Chico^fs(2)4

(Luo et al., 2020)

chic¹

chico-1

(Tu et al., 2002)

chico1

(Vigne et al., 2009, Wagaman et al., 2004, Bartke et al., 2002)

chico^1/2

(Tiefenböck et al., 2010)

chico¹

(Okenve-Ramos et al., 2024, Saedi et al., 2024, Yu et al., 2024, Charroux and Royet, 2022, Yamaguchi et al., 2022, Azuma et al., 2021, Bjedov et al., 2020, Ruzzi et al., 2020, Sanaki et al., 2020, Chatterjee et al., 2019, Wang et al., 2019, Funakoshi et al., 2018, Henstridge et al., 2018, Su et al., 2018, Banerjee et al., 2017, Bolukbasi et al., 2017, Fernandes et al., 2017, Luhur et al., 2017, Afschar et al., 2016, Naganos et al., 2016, Ratliff et al., 2016, Slack et al., 2015, Charroux and Royet, 2014, Chng et al., 2014, Knight et al., 2014, Radermacher et al., 2014, Almudi et al., 2013, Bai et al., 2013, Esslinger et al., 2013, Hirano et al., 2013, Jagut et al., 2013, Na et al., 2013, Yang et al., 2013, Banerjee et al., 2012, Chakrabarti et al., 2012, Kapuria et al., 2012, Naganos et al., 2012, Pallares-Cartes et al., 2012, Albrecht et al., 2011, Bartlett et al., 2011, Murillo-Maldonado et al., 2011, Murillo-Maldonado et al., 2011, Slack et al., 2011, Wang et al., 2011, Biteau et al., 2010, Hull-Thompson et al., 2009, Werz et al., 2009, Wong et al., 2009, Wang et al., 2008, Shcherbata et al., 2007, Wagaman and Rand, 2007, Christensen and Cook, 2006.8.30, Richard et al., 2005, Shingleton et al., 2005)

flp^ry4

(Spradling, 1990.8.1)

fs(2)4

(Riesgo-Escovar, 2001.2.7)

fs(2)4¹

(Goberdhan et al., 1999, Riesgo-Escovar et al., 1996)

fs(2)ry4

fs(2)ry⁴

(Clegg et al., 1993)

Name Synonyms

Secondary FlyBase IDs

FBal0034657
FBal0086688

References (97)

Report Sections

Open Close