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General Information
Symbol
Dmel\fzy4
Species
D. melanogaster
Name
FlyBase ID
FBal0031373
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    55% of fzy4 mutant clones generated in the brain during the larval stages do not contain neuroblasts, compared to <10% in controls.

    Unlike in wild type, fzy4 mutant neuroepithelial cell clones in the larval optic lobe fail to proliferate.

    Unlike in wild type, almost all fzy4 mutant neuroblast clones in the larval brain fail to proliferate.

    fzy5032/fzy4 mutant neuroblasts maintain a single nucleus and cell diameters are similar to wild type.

    At 25oC, embryonic lethal, ventral epidermis absent, CNS degenerate, PNS absent. At 18oC, embryonic lethal, holes in ventral epidermis, CNS degenerate.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Suppressed by
    NOT Suppressor of
    Statement
    Reference

    fzy[+]/fzy4 is a non-suppressor of increased cell death phenotype of shtd1

    Phenotype Manifest In
    Suppressed by
    NOT Suppressor of
    Statement
    Reference

    fzy[+]/fzy4 is a non-suppressor of eye phenotype of shtd1

    fzy[+]/fzy4 is a non-suppressor of ommatidium phenotype of shtd1

    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    Expression of Mmus\Cdc20Scer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroepithelial cell clones in the larval optic lobe.

    Expression of Mmus\Cdc20Scer\UAS.cKa under the control of Scer\GAL4elav.PU partially rescues the proliferation defects seen in fzy4 mutant neuroblast clones in the larval brain.

    Expression of Mmus\Cdc20mut.Scer\UAS under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroepithelial cell clones in the larval optic lobe.

    Expression of Mmus\Cdc20mut.Scer\UAS under the control of Scer\GAL4elav.PU partially rescues the proliferation defects seen in fzy4 mutant neuroblast clones in the larval brain.

    Complementation and Rescue Data
    Partially rescued by
    Comments

    Expression of fzyScer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroepithelial cell clones in the larval optic lobe.

    Expression of fzyScer\UAS.cKa under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroblast clones in the larval brain.

    Expression of fzyScer\UAS.5032 under the control of Scer\GAL4elav.PU rescues the proliferation defects seen in fzy4 mutant neuroepithelial cell clones in the larval optic lobe.

    Expression of fzyScer\UAS.5032 under the control of Scer\GAL4elav.PU fails to rescue the proliferation defects seen in fzy4 mutant neuroblast clones in the larval brain.

    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    P. Simpson.

    Comments
    Comments

    Phenotypic data included in FBrf0051973.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (5)