FlyBase Allele Report: Dmel\gsb[IIX62]

General Information

Symbol

Dmel\gsb^IIX62

Species

D. melanogaster

Name

FlyBase ID

FBal0031424

Feature type

allele

Associated gene

Dmel\gsb

Associated Insertion(s)

Carried in Construct

Also Known As

gsb-d^IIX62

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Andrew et al., 1997)

Mutagen

ethyl methanesulfonate

(Perrimon and Mahowald, 1987)

Progenitor genotype

Caused by aberration

Df(2R)gsb

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic central nervous system & neuroblast

(Zhang et al., 1994)

embryonic dorsal epidermis

(Perrimon and Mahowald, 1987)

embryonic head

(Perrimon and Mahowald, 1987)

larval DA1 motor neuron

(Zhang et al., 1994)

larval RP2 motor neuron

(Zhang et al., 1994)

neuroblast NB6-4

(Deshpande et al., 2001)

neuroblast NB7-3 | ectopic

(Deshpande et al., 2001)

pCC neuron

(Zhang et al., 1994)

U neuron

(Zhang et al., 1994)

Detailed Description

Statement

Reference

A duplicated NB 7-3 is formed in 70% of hemisegments in mutant embryos, and NB 6-4 markers are absent in 100% of hemisegments.

(Deshpande et al., 2001)

Double mutant phenotype with CrebA mutants is additive.

(Andrew et al., 1997)

Row five neuroblasts of the embryonic CNS are transformed into row 3 neuroblasts. CQ neurons are deleted, anterior corner cell, posterior corner cell and RP2 neurons are duplicated, and EL neurons are unaffected.

(Zhang et al., 1994)

Head and dorsal closure defects.

(Perrimon and Mahowald, 1987)

In clonal analysis, ectopic bristles are not seen in the naked cuticle.

(Wieschaus and Riggleman, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

An ectopic NB 7-3 is formed in 76% of hemisegments in gsb^IIX62 ; nkd² embryos.

(Deshpande et al., 2001)

In ptc⁹, gsb^- double mutants large posterior denticles of each abdominal belt are missing, region ventral naked cuticle is missing. Denticles of intermediate size pointing posteriorly cover the whole of the segments.

(Hidalgo, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

gsb^IIX62 is rescued by gsb^hs.PZ

(Zhang et al., 1994)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2528

Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/CyO

Kyoto

107384

y^* w^*; Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/SM1, speck²

Notes on Origin

Discoverer

Comments

The expression of l(1)sc is unaltered in early homozygous mutant embryos.

(Martin-Bermudo et al., 1991)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

gsb-d^IIX62

(Zhang et al., 1994, Hidalgo, 1991, Martin-Bermudo et al., 1991, Frasch and Levine, 1987, Perrimon and Mahowald, 1987, Wieschaus and Riggleman, 1987)

gsb^DIIX62

(Andrew et al., 1997)

gsb^IIX62

(Herrero et al., 2014, Kuzin et al., 2011)

gsb^IIX6

(Deshpande et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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