Open Close
General Information
Symbol
Dmel\hi22
Species
D. melanogaster
Name
FlyBase ID
FBal0031449
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion of sequences encoding the h protein.

Deletion of the en protein coding sequences.

Deletion of the sequences encoded in the h transcript.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hi22/+ first instar larvae only rarely have segmentation defects.

hi22/h674 embryos have salivary glands with either branched or expanded lumens.

Heterozygotes frequently have terminal incisions in the wing.

Interacts with RpII140wimp maternal effect.

Transheterozygotes with hL43a are lethal, strong pair-rule phenotype.

Homozygous phenotype is variable. In some cases half the normal number of denticle bands form, due to a deletion of pattern elements from approximately the middle of one segment to a homologous position in the next segment ("pair-rule segmentation phenotype"). In other cases the deletions span more than one segment, resulting in the fusion of the compound segments. Weaker phenotypes are also seen, involving the formation of denticles corresponding to A2, A6 or both. Heterozygotes show some cuticle pattern defects.

Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1. The denticle belts associated with the A3/4 and A5/6 composite segments are often fused in homozygous larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The frequency of cuticular segmentation phenotypes in hi22/+ first instar larvae is significantly enhanced in animals with a egl3e/egl1 mutant mother.

N55e11/+; hi22/+ flies have severe notching of the wings. Nnd-1/Y; hi22/+ flies have severe notching of the wings. N55e11/+; Df(2R)vg-B/+ hi22/+ flies are viable and have small wings.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

Selected on the basis of its failure to complement the bristle phenotype of either h1 or h2.

The expression of l(1)sc is altered during stage 9 in homozygous mutant embryos.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (16)