Allele Dmel\hh^rJ413

General Information
Symbol	Dmel\hh^rJ413	Species	D. melanogaster
Name		FlyBase ID	FBal0031489
Feature type	allele	Associated gene	Dmel\hh

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (FlyBase, 1996-, Heberlein et al., 1993, BDGP Project Members, 1994-1999, Spradling et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:18,953,010..18,953,010 3R:18,952,917..18,952,917 (Guillen et al., 1995, BDGP Project Members, 1994-1999, Heberlein et al., 1993, FlyBase, 1996-, Spradling et al., 1999)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Caused by insertion	P{PZ}hh^rJ413 (Guillen et al., 1995, BDGP Project Members, 1994-1999, Heberlein et al., 1993, FlyBase, 1996-, Spradling et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999)
Phenotype Manifest In
	eye disc \| somatic clone (Lee et al., 2002) photoreceptor cell \| somatic clone (Lee et al., 2002)
Detailed Description
	Statement Reference Mutant clones at the posterior margin of the eye disc lack photoreceptor differentiation. (Lee et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference hh[+]/hh^rJ413 is an enhancer of visible \| dominant phenotype of Egfr^E1 (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of visible \| recessive phenotype of dac^P (Mardon et al., 1994) hh[+]/hh^rJ413 is an enhancer of visible phenotype of Ret^GMR.PR (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Phenotype Manifest In
Enhancer of
Statement Reference hh[+]/hh^rJ413 is an enhancer of eye phenotype of dac^P (Mardon et al., 1994) hh[+]/hh^rJ413 is an enhancer of eye phenotype of Egfr^E1 (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of eye phenotype of Ret^GMR.PR (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) hh[+]/hh^rJ413 is an enhancer of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005) hh^rJ413 is an enhancer of eye phenotype of bun^rI043 (Treisman et al., 1995)
Suppressor of
Statement Reference hh^rJ413 is a suppressor \| partially of eye disc \| somatic clone \| cell non-autonomous phenotype of hyd^K3.5 (Lee et al., 2002) hh^rJ413 is a suppressor of photoreceptor cell \| ectopic \| somatic clone phenotype of hyd^K3.5 (Lee et al., 2002)
NOT Suppressor of
Statement Reference hh^rJ413 is a non-suppressor of phenotype of slmb⁰⁵⁴¹⁵ (Theodosiou et al., 1998) hh^rJ413 is a non-suppressor of phenotype of slmb^e4-1 (Theodosiou et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference hyd^K7.19 hh^rJ413 double mutant clones in the eye which are also expressing ci^76.Scer\UAS under the control of Scer\GAL4^αTub84B.PL do not show overgrowth. The phenotype of hyd^K3.5 clones in the eye disc is partly suppressed if they are also mutant for hh^rJ413; ectopic photoreceptors are no longer formed in or around the clone, but some clones still induce overgrowth of wild-type tissue. (Lee et al., 2002) Has no effect on the frequency of outgrowths in slmb mutant clones. (Theodosiou et al., 1998) hh^rJ413 dominantly enhances the recessive eye phenotype of dac^P. (Mardon et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	10321 ry⁵⁰⁶ P{PZ}hh^rJ413 CG31457^rJ413/TM3, ry^RK Sb¹ Ser¹
Notes on Origin
Discoverer	Gaul, Higgins and Rubin.
	Associated with: CG31457^rJ413. The P{PZ}hh^rJ413 insertion is identified as an allele of hh on genetic grounds as well as an allele of CG31457 on molecular grounds (it is within the CG31457 transcription unit). (FlyBase, 1996-)
Comments
	Complements: cnc⁰³⁹²¹. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	hh^rJ413 l(3)rJ413 (Spradling et al., 1999)
Name Synonym
Secondary FlyBase IDs

References ( 11 )
Research paper	Read et al., 2005, Genetics 171(3): 1057--1081 A Drosophila model of multiple endocrine neoplasia type 2. [FBrf0190765] Lee et al., 2002, Development 129(24): 5697--5706 The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. [FBrf0151945] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489] Theodosiou et al., 1998, Development 125(17): 3411--3416 slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. [FBrf0104785] Guillen et al., 1995, Development 121(10): 3447--3456 The function of engrailed and the specification of Drosophila wing pattern. [FBrf0083983] Treisman et al., 1995, Development 121(9): 2835--2845 Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF--responsive gene. [FBrf0084455] Mardon et al., 1994, Development 120(12): 3473--3486 dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila. [FBrf0075101] Heberlein et al., 1993, Cell 75(5): 913--926 The TGF homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. [FBrf0064498]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946]

Allele Dmel\hhrJ413

Allele Dmel\hh^rJ413