Open Close
General Information
Symbol
Dmel\hydhs1
Species
D. melanogaster
Name
FlyBase ID
FBal0031510
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    hydhs1/hydC017 mutants exhibit abnormalities in spermatogenesis. One such abnormality is for nuclei scattered through the elongated cysts to exhibit a round shape instead of a 'needle' shape. In rare cases, the group of needle-shaped nuclei can be found in the correct place in the cyst; however, some of the nuclei are evidently incorrectly condensed. Approximately 90% of nuclei and micronuclei do not reach the correct cyst pole.

    At 25oC homozygotes show hyperplastic imaginal disc overgrowth, affecting wing, haltere and eye-antennal discs, whereas at 18oC development proceeds normally. Mutant discs implanted into wild type hosts for metamorphosis overgrow and differentiate normal imaginal structures. Mutant larvae do not grow beyond the maximum size seen for wild type. A few escapers eclose as adults.

    Imaginal discs show gap-junctional communication defects: coupling is severely diminished.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    hydhs1 has cytokinesis defective phenotype, enhanceable by pAbp[+]/pAbpk10109

    Enhancer of
    Statement
    Reference

    hyd[+]/hydhs1 is an enhancer of cytokinesis defective phenotype of pAbpk10109

    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    pAbpk10109/hydhs1 trans-heterozygous double mutants exhibit spermatogenesis defects. Approximately 30% of head bundles in the sperm contain both round- and needle-shaped nuclei. Abnormal nuclei scattering occurs at low frequency. Cytokinetic abnormalities are also increased in these double mutants.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (3)