mutant clones in the eye imaginal disc are overgrown compared to controls.
The overall morphology of dco3
mutants is abnormal, with extensive rippling and loss of normal morphological features including the wing pouch.
transheterozygotes are similar to dco3
The rough eye phenotype observed in Fmr1sev.PW
flies is suppressed in a dco3
clones in the adult abdomen do not show planar cell polarity defects.
clones in the wing imaginal disc are larger than their associated wild type sibling clones.
mutant wing discs collected 36-48 hours after the L2-L3 molt are overgrown.
wing discs exhibit an overgrowth phenotype.
Homozygotes show lethality in larval or early pupal stages, with overgrown discs. Pharate adults generated with dco3
/hypomorph combinations show morphogenetic aberrations including duplicated structures. dco3
in combination with dco2
: lethality in larval or early pupal stages, with overgrown discs. dco3
in combination with dcole88
: show lethality during larval or early pupal stages with typical dco3
phenotype (swollen tarsi with or without head defects). Discs overgrown. dco3
in combination with dcoS144701
: adult viable with reduced eyes extra vibrissae and expanded wings. dco3
somatic clones in the discs show an autonomous overgrowth phenotype. Cell size is unaffected. Animals with many clones show delayed pupariation.
Hyperplastic overgrowth mutant. Apico-lateral junctional complexes appear normal.
Hyperplastic imaginal disc overgrowth, affecting all discs. Discs implanted into wild type hosts for metamorphosis over grow and differentiate abnormal imaginal structures. dco18
mutant larvae grow at a normal rate until end of feeding period of last larval instar, when growth slows and then stops: they eventually reach double the weight of wild type pupariating larvae. The ecdysteroid secretory activity of dlg1 and dco ring glands in vitro is 1/6 that of wild type.
Larval life prolonged by up to 14 days. Overgrown larvae show bloating and an increase in water content.
When raised at 25oC the larval period of homozygotes and interallelic heterozygotes is greatly extended and they develop overgrown imaginal discs. Imaginal discs show gap-junctional communication defects: coupling is severely diminished. The single layer epithelium is maintained during overgrowth and they differentiate into the correct but abnormal adult structures.