FlyBase Allele Report: Dmel\Orc3[P1]

General Information

Symbol

Dmel\Orc3^P1

Species

D. melanogaster

Name

FlyBase ID

FBal0032070

Feature type

allele

Associated gene

Dmel\Orc3

Associated Insertion(s)

P{w^d19.3}Orc3^P1

Carried in Construct

Also Known As

P{w^d19.3}lat^P1

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Pinto et al., 1999, Boynton and Tully, 1992)

Mutagen

P-element activity

PM hybrid dysgenesis

(Tully et al., 1992)

Progenitor genotype

Associated Insertion(s)

P{w^d19.3}Orc3^P1

Cytology

Description

Insertion into lat transcription unit. 28bp deletion in intron d (nucleotides 895-922). 4bp deletion 12bp 5' of the translation start site (at nucleotides 1161-1163). 8bp duplication 134bp 5' of the translation start site.

(Pinto et al., 1999)

Insertion P element at cytological location 49F7--49F8.

(Boynton and Tully, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:13,205,342..13,205,342

(Pinto et al., 1999, Boynton and Tully, 1992, Tully et al., 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning

(Rohrbough et al., 1999)

abnormal learning | recessive

(Boynton and Tully, 1992)

abnormal neurophysiology | larval stage | recessive

(Rohrbough et al., 1999)

viable

(Rohrbough et al., 1999)

Phenotype Manifest In

adult mushroom body

(Pinto et al., 1999)

Detailed Description

Statement

Reference

Homozygotes show a 20% reduction, and hemizygotes an 80% reduction, in mushroom body volume. Hemizygotes show a 20% reduction in central complex volume.

(Pinto et al., 1999)

Mutant EJC amplitudes (larval muscle 12 and muscle 6) are significantly larger than wild type at all Ca²⁺ concentrations. Short term synaptic facilitation, synaptic augmentation and posttetanic potentiation are reduced in mutants.

(Rohrbough et al., 1999)

Specific defect in learning and memory retention. Olfactory acuity, nonassociative change in odour avoidance and shock reactivity is not defective.

(Boynton and Tully, 1992)

Flies exhibit defective initial learning levels, thereafter mutant memory decays as wild type.

(Tully et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Orc3^P1 is rescued by Orc3^+t17.1

(Pinto et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Hypomorphic excision alleles have been generated.

(Tully et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Orc3^P1

lat^P1

(van Swinderen, 2007)

latheo^P1

(Guo and Zhong, 2006)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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