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General Information
Symbol
Dmel\mei-S3323
Species
D. melanogaster
Name
FlyBase ID
FBal0032116
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G22123080A

Amino acid change:

G28D | mei-S332-PA; G28D | mei-S332-PB

Reported amino acid change:

G28D

Comment:

G28D falls within the predicted coiled coil.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: G28D. G28D falls within the predicted coiled coil.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Transmission rate of Dp(1;f)J21A through females to progeny is 28%, mei-S332 mutation has no effect on transmission. Mutation has no effect on Dp(1;f)J21A transmission in males.

Levels of nondisjunction are higher in males than females.

Defects in sister chromatid cohesion. 10-15% total nondisjunction, male predominant nondisjunction. Hemizygotes exhibited a moderate increase in total nondisjunction. High frequency of premature separation of sister chromatids in prophase II. Nondisjunction of chromosomes 2 and 3 in males.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
mei-S3323
Name Synonyms
Secondary FlyBase IDs
    References (5)