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General Information
Symbol
Dmel\mysxR04
Species
D. melanogaster
Name
FlyBase ID
FBal0032209
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G8068869A

Comment:

G to A base change at the splice acceptor. Causes a frameshift after aa residue 825.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: G?A. Mutation at the exon 7 splice acceptor site, resulting in a frameshift after amino acid residue 825.

Indistinguishable from wild type on Southern blot. Immunoblots indicate βPS protein levels are comparable to wild type (within a factor of two).

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hemizygous embryos derived from heterozygous females often have a "tail up" phenotype.

90-100% double heterozygotes with amorphic if mutations die. Double heterozygotes with hypomorphic if mutations show partial genetic interaction. Class II and III if mutations show almost no genetic interaction.

In embryos derived from mutant germline, at the end of germband retraction the anterior ventral cells of the germband move slightly more anteriorly than corresponding tissue in wild type animals. This phenotype is more extreme than for the simple loss of function mys11. The opening of the stomodeum has moved to the anterior tip of the embryo.

Widespread muscle attachment abnormality in embryo, consequently mobility is impaired.

mysxR04/mys8 flies die at 25oC but survive at 18oC, and have inflated or blistered wings and often show a gap between the pigment cell feet constituting the fenestrated membrane and the layer of pigmented subretinal cells found below the basement membrane.

Variability of morphological and immunostaining phenotypes. Some embryos that are clearly mysxR04 based on head phenotypes had βPS staining at muscle attachment sites.

Heterozygotes with mys8 are lethal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement
Reference

mys[+]/mysxR04 is a non-enhancer of visible | dominant phenotype of sogEP7

mys[+]/mysxR04 is a non-enhancer of visible | dominant phenotype of sogEP11

NOT Suppressor of
Statement
Reference

mys[+]/mysxR04 is a non-suppressor of visible | dominant phenotype of sogEP7

mys[+]/mysxR04 is a non-suppressor of visible | dominant phenotype of sogEP11

Other
Statement
Reference
Phenotype Manifest In
NOT Enhancer of
Statement
Reference

mys[+]/mysxR04 is a non-enhancer of wing vein phenotype of sogEP7

mys[+]/mysxR04 is a non-enhancer of wing vein phenotype of sogEP11

NOT Suppressor of
Statement
Reference

mys[+]/mysxR04 is a non-suppressor of wing vein phenotype of sogEP7

mys[+]/mysxR04 is a non-suppressor of wing vein phenotype of sogEP11

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)