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General Information
Symbol
Dmel\not1
Species
D. melanogaster
Name
FlyBase ID
FBal0032291
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the wing fail to form hairs or have very small hairs. Subtle defects in polarity are also seen in these wings.

9.7% of not1/Df(3L)W4 animals show prepupal lethality and 19.4% have a strong "nonstop" phenotype (more than 50% of photoreceptor cell axon bundles pass the lamina and hyperinnervate the medulla). In mosaics in which about 60-80% of cells in the eye are homozygous (and the optic lobe is wild type), the axons of photoreceptor cells R1-R6 terminate in the lamina (as in wild type). Minor defects in ommatidial polarity and cell number are seen in these mosaic eyes; 88% of ommatidia have a normal number and array of photoreceptor cells, 12% of ommatidia lack between 1 to 4 photoreceptor cells and about 19% of the normal ommatidia are misoriented. Rhabdomere morphology indicates that mutant R1-R6 cells do not adopt an R7 cell fate. In mosaic animals with homozygous clones in the lamina precursors and lamina neurons the photoreceptor cell pattern appears normal. Normal rows of wild-type epithelial, marginal and medulla glial cells form beneath these clones. Mutant clones and wild-type control clones in the glial precursor cell (GPC) area are similar in size and frequency. In mosaic animals which have homozygous clones in the GPC area the number of mutant glial cells bordering the lamina plexus is markedly reduced compared to controls. Blocks of mutant cells are never seen adjacent to the lamina plexus.

In hemizygotes R1-R6 neurons project through the lamina and terminate in the medulla. A few appear to stop in the lamina. In the developing optic ganglia the regions of the outer proliferation centre (OPC) and lamina precursor cells (LPC) are closer together and the shape of the inner proliferation centre (IPC) is oval rather than round.

strong hyperinnervation of optic medulla anlagen

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

not1/Df(3L)W4 has some die during P-stage phenotype, enhanceable by Prosbeta6[+]/ProsĪ²61

Phenotype Manifest In
Enhanced by
Statement
Reference

not1/Df(3L)W4 has photoreceptor cell & axon phenotype, enhanceable by Pros26[+]/ProsĪ²61

Additional Comments
Genetic Interactions
Statement
Reference

The prepupal lethality and photoreceptor axon targeting phenotype of not1/Df(3L)W4 animals is enhanced by one copy of Pros261; 78.5% of animals show prepupal lethality and 69.4% show a strong "nonstop" phenotype (more than 50% of photoreceptor cell axon bundles pass the lamina and hyperinnervate the medulla).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
not1
Name Synonyms
Secondary FlyBase IDs
    References (5)