FB2021_02, released April 13, 2021

Allele: Dmel\Raf107

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General Information
Symbol
Dmel\Raf107
Species
D. melanogaster
Name
FlyBase ID
FBal0032417
Feature type
allele
Associated gene
Dmel\Raf
Associated Insertion(s)
Carried in Construct
Also Known As
D-raf107
Key Links
Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Melnick et al., 1993)

loss of function allele

(Brunner et al., 1994)
Mutagen
ethyl methanesulfonate
(Melnick et al., 1993)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos exhibit defects in posterior pattern.

      (Radke et al., 1997)

      Class 1 allele: Unrescued embryos (lacking maternal and zygotic phl activity) fail to differentiate into structured embryos and degenerate around 7 hrs of development. Rescued embryos (carrying wild type phl from their father) miss most structures posterior to abdominal segment 6 or 7 and anteriorly a portion of the cephalopharyngeal skeleton, labral sense organ and medial tooth are deleted. fkh expression (in wild type evident in hindgut, Malpighian tubule(s) and anal pads) entirely absent from class 1 embryos. Expression of tll, hkb, hb, fkh absent from both rescued and unrescued embryos, 7th ftz stripe deleted and 6th ftz stripe variably deleted/expanded. Conclude from 0% to 20--25% EL of blastoderm embryos deleted in class 1 alleles.

      (Melnick et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Raf107 has partially lethal phenotype, suppressible by rlSem/rl+

      (Brunner et al., 1994)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Reduced viability is dominantly suppressed by rlSem.

      (Brunner et al., 1994)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Raf107 is rescued by RafcBa

      (Radke et al., 1997)
      Comments

      Injection of wild type RNA rescues the filzkorper, tuft and anal pads.

      (Radke et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      J.M. Dura.

      (Melnick et al., 1993)
      Comments
      Comments

      Comparison of homozygotes for this allele with heterozygotes for this allele and Df(1)64c18 (deleted for phl) is the basis for amorph designation.

      (Melnick et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      D-raf107
      (Radke et al., 1997, Melnick et al., 1993)
      Raf107
      phl107
      raf107
      (Brunner et al., 1994)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)