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General Information
Symbol
Dmel\pnrVX1
Species
D. melanogaster
Name
FlyBase ID
FBal0032465
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

14 nucleotide deletion causing a frameshift stop truncating the protein to 514 amino acids

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

14 nucleotide deletion, between nucleotides 1715 and 1728, causing a frameshift stop truncating the protein to 514 amino acids, and removing the putative α-helices.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pnrVX1 heterozygotes exhibit a loss of dorsocentral bristles compared to wild-type (1.86 bristles per heminotum compared to 2.0 in wild-type controls).

pnrV1/pnrVX1 mutants show abnormal muscle attachments. The dorsal medial muscle (DLM)s appear as a single fibre that resembles the lateral oblique dorsal muscle (DVM III) in its orientation.

In pnrV1/pnrVX1 mutants the wg-dependent dorsocentral bristles and scutellar bristles are missing.

Lethality occurs at larval or early pupal stages. Heterozygotes occasionally lack one dorsocentral bristle. Heterozygotes with pnrV1 are viable.

Heterozygotes are missing one of the two dorsocentral bristles. Homozygous clones of cells are missing one or both bristles. Dominant phenotype enhanced in viable transallelic combinations with pnrVX1. Homozygotes die as young larvae with no obvious mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

pnrVX1 has dorsocentral bristle phenotype, enhanceable by Iswi2

pnrVX1 has dorsocentral bristle phenotype, enhanceable by tou2

Suppressor of
Statement
Reference

pnrVX1 is a suppressor of dorsocentral bristle phenotype of tou2

Additional Comments
Genetic Interactions
Statement
Reference

tou2/+ ; pnrVX1/+ flies exhibit on average 1.57 dorsocentral bristles per heminotum, compared to 1.86 bristles per heminotum in pnrVX1 heterozygotes, 1.4 bristles per heminotum in tou2/+ and 2.0 dorsocentral bristles per heminotum in wild-type. Iswi2/+ ; pnrVX1/+ flies display on average 1.61 dorsocentral bristles per heminotum, so aggravating the pnrD1/+ single mutant phenotype (1.86 bristles/heminotum).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Class B allele.

Class 3 pnr allele: dominant allele causing loss of bristles.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (9)