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General Information
Symbol
Dmel\rut1084
Species
D. melanogaster
Name
FlyBase ID
FBal0032623
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lArB} insertion within 200bp upstream of the presumed transcription start site.

Insertion components
P{lArB}rut1084
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant males lack 30-minute courtship memory after 1 hour of conditioning in a courtship conditioning assay. This defect is significantly suppressed if the males are fed 0.1mM 20-hydroxy-ecdysone for 10 minutes immediately prior to conditioning.

The frequency of spontaneous release (miniature excitatory junctional currents) at the neuromuscular junction is reduced compared to wild type.

Severe defects in initial learning and in 60 minute memory retention, measured in negatively reinforced olfactory discrimination paradigm.

In an odour avoidance paradigm exhibits significantly reduced learning.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of DopEcRScer\UAS.cIb under the control of Scer\GAL4Mef2.247.Switch in adult mushroom body neurons (using RU486 to limit the timing of expression) does not restore courtship memory in a courtship conditioning assay in rut1084 males. However, if these flies are also fed 0.01mM 20-hydroxy-ecdysone (a concentration that does not rescue courtship memory in rut1084 single mutants), significant rescue of courtship memory is seen.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
  • FBal0032626
References (6)