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General Information
Symbol
Dmel\schb.PP
Species
D. melanogaster
Name
hunchback promoter construct of Parkhurst
FlyBase ID
FBal0032646
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The hb promoter drives expression of the sc coding region.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

2 copies of schb.PP cause male lethality.

Male-specific lethality due to inappropriate activation of Sxl. Can rescue the female lethality of hhb.PP.

Causes male specific lethality and activates ectopic Sxl expression in the anterior of male embryos (Parkhurst et al., Cell 63: 1179--1191.)

Female viability is unaffected. Head morphology of males is defective.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

schb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hW

schb.PP has lethal | female phenotype, suppressible by hΔSPPSS.hb

schb.PP has lethal | female phenotype, suppressible by hΔWRPW.hb

schb.PP has lethal | female phenotype, suppressible by hhb.PP

schb.PP has lethal | male phenotype, suppressible by Xlae\hhb.PD

schb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hb

schb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hbHLH

schb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hHLH

schb.PP has lethal | female phenotype, suppressible by E(spl)m8-HLH::hOr

schb.PP has lethal | male phenotype, suppressible by SxlM1

NOT suppressed by
Statement
Reference

schb.PP has lethal | female phenotype, non-suppressible by da::hb

schb.PP has lethal | female phenotype, non-suppressible by da::hbHLH

schb.PP has lethal | female phenotype, non-suppressible by da::hHLH

schb.PP has lethal | female phenotype, non-suppressible by E(spl)m8-HLH::hOrW.1

schb.PP has lethal | female phenotype, non-suppressible by hΔOrange.hb

schb.PP has lethal | female phenotype, non-suppressible by hM39L.hb

schb.PP has lethal | female phenotype, non-suppressible by hM39R.hb

schb.PP has lethal | female phenotype, non-suppressible by hML.hb

schb.PP has lethal | female phenotype, non-suppressible by hMR.hb

schb.PP has lethal | female phenotype, non-suppressible by hP37N.hb

schb.PP has lethal | female phenotype, non-suppressible by hP37T.hb

schb.PP has lethal | female phenotype, non-suppressible by hPNMR.hb

schb.PP has lethal | female phenotype, non-suppressible by hRIP.hb

schb.PP has lethal | female phenotype, non-suppressible by h::scb

schb.PP has lethal | female phenotype, non-suppressible by h::scbHLH

schb.PP has lethal | male phenotype, non-suppressible by E(spl)m8-HLHhb.PD

schb.PP has lethal | female phenotype, non-suppressible by E(spl)m8-HLHhb.PD

Other
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of hhb.PP can rescue male lethality caused by schb.PP. Deletion of the bHLH and orange domains of h render it unable to rescue male lethality, the WRPW domain is not required for rescue. Expression of E(spl)hb.PD cannot rescue male lethality caused by schb.PP.

Ectopic h expression (hhb.PP) rescues schb.PP male lethality. Extra copies of da+ do not effect male lethality of schb.PP.

schb.PP/SxlM1 male embryos are fully viable.

Xenogenetic Interactions
Statement
Reference

Expression of Xlae\hhb.PD can rescue male lethality caused by schb.PP.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Restores posterior Sxl protein expression in scsisB-1 female embryos. scsisB-1; l(1)schb.PP and sisA1; schb.PP embryos lack posterior Sxl expression.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
schb.PP
Name Synonyms
hunchback promoter construct of Parkhurst
Secondary FlyBase IDs
    References (4)