sd[ETX4]/Y males display an enhanced wing phenotype in a vgnull/+ background.
The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) to sdETX4 animals, almost completely rescues the wing phenotype with only a small amount of wing notching and occasional loss of bristles on the wing margin. The L5 wing vein is also usually incompletely formed. sdETX4, vg1/vg79d5 wings are very small and deformed. The addition of sd::vgScer\UAS.sdTEA (driven by Scer\GAL4vg.PM) significantly rescues the wing defects.
sdETX4 vg79d5 double homozygotes show a significant reduction in wing size and an uplifting of the postscutellar bristles, similar to the phenotype of vg1 homozygotes. Flies heterozygous for vg79d5 in a sdETX4 background have a phenotype almost as strong as sdETX4 vg79d5 double homozygotes. Flies heterozygous for vgnull in a sdETX4 background do not show such a significant reduction in the wing as flies heterozygous for vg79d5 in a sdETX4 or sd1 background. Females expressing vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 in a sdETX4/+ background die in the late pupal stage. They show ectopic wing-like outgrowths at the posterior of the head capsule, with strong deformation of the eye. Males expressing vgScer\UAS.cZa under the control of Scer\GAL4ptc-559.1 in a hemizygous sdETX4 background do not show such extensive wing-like outgrowths and show only slight deformation of the eye. These males can emerge from the pupae, although they die within a few hours.