FlyBase Allele Report: Dmel\sev[S11.Tag:MYC]

General Information

Symbol

Dmel\sev^S11.Tag:MYC

Species

D. melanogaster

Name

FlyBase ID

FBal0032692

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

P{sev5}

Also Known As

sev^S11, sE-sev^S11, sev-S11

Key Links

Allele class

gain of function allele

Mutagen

Nature of the Allele

Allele class

gain of function allele

(Kim et al., 2006, Kockel et al., 1997, Olivier et al., 1993, Basler et al., 1991)

Mutagen

in vitro construct - regulatory fusion

(Le and Simon, 1998, Olivier et al., 1993, Basler et al., 1991)

in vitro construct - coding region fusion

(Basler et al., 1991)

in vitro construct - deletion

(Olivier et al., 1993)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{sev5}

Cytology

Nature of the lesion

Statement

Reference

A constitutively active form of sev is expressed under the control of two copies of the sev enhancer fused to an Hsp70 promoter.

(Kussick et al., 1993)

A truncated, activated sevenless kinase overexpressed under the control of a duplicated sev enhancer.

(Olivier et al., 1993)

sev amino acids 1865 to 2554, lacking most of the extracellular domain, encoded by cDNA are under the control of the duplicated sev enhancer and Hsp70 promoter. N-terminal signal sequence is provided by an inframe fusion with the signal peptide of Lcp3, and the protein is tagged with a Tag:MYC epitope.

(Basler et al., 1991)

Allele components

Product class / Tool use(s)

Regulatory region(s)

sev

Encoded product / tool

sev

Tagged with

Tag:MYC

epitope tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cone cell

(Feller et al., 2002, Bausenwein et al., 2000, Luschnig et al., 2000, Kauffmann et al., 1996)

denticle belt

(Maixner et al., 1998)

embryonic/first instar larval cuticle

(Maixner et al., 1998)

embryonic/larval tracheal system

(Lee et al., 1996)

embryonic head

(Maixner et al., 1998)

eye

(Sese et al., 2006, Feller et al., 2002, Ciapponi et al., 2001, Morey et al., 2001, Luschnig et al., 2000, Herbst et al., 1999, Le and Simon, 1998, Maixner et al., 1998, Polaczyk et al., 1998, Therrien et al., 1998, Zeidler et al., 1996, Kussick et al., 1993, Hafen and Basler, 1991)

eye, with Scer\GAL4^hs.2sev

(Almudi et al., 2009)

eye photoreceptor cell

(Kockel et al., 1997, Basler et al., 1991)

eye photoreceptor cell | ectopic

(Luschnig et al., 2000)

eye photoreceptor cell | increased number

(Kim et al., 2006, Rintelen et al., 2003)

ommatidium

(Ciapponi et al., 2001, Morey et al., 2001, Luschnig et al., 2000, Pazman et al., 2000, Herbst et al., 1999, Le and Simon, 1998, Hafen and Basler, 1991)

photoreceptor cell

(Morey et al., 2001, Hou et al., 1997)

photoreceptor cell R7

(Sawamoto et al., 1996, Kauffmann et al., 1995, Kramer et al., 1995)

photoreceptor cell R7 | ectopic

(Sese et al., 2006, Feller et al., 2002, Smith et al., 2002, Ciapponi et al., 2001, Morey et al., 2001, Bausenwein et al., 2000, Luschnig et al., 2000, Pazman et al., 2000, Le and Simon, 1998, Polaczyk et al., 1998)

photoreceptor cell R7 | increased number

(Rintelen et al., 2003)

photoreceptor cell R7 | increased number, with Scer\GAL4^hs.2sev

(Almudi et al., 2009)

rhabdomere

(Basler et al., 1991)

Detailed Description

Statement

Reference

Flies expressing sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev have a rough eye phenotype. Extra R7 photoreceptor cells are present in the ommatidia.

(Almudi et al., 2009)

The eyes of flies that express sev^{S11.T:Hsap\MYC} show a greater number of photoreceptor cells per ommatidium than wild-type flies.

(Kim et al., 2006)

Flies carrying sev^{S11.T:Hsap\MYC} have a rough eye phenotype, with an average of 4.3 R7 cells per ommatidium.

(Sese et al., 2006)

Flies expressing sev^{S11.T:Hsap\MYC} have extra R7 photoreceptors in the eye and occasionally have extra outer photoreceptor cells. Cells outside the ommatidial preclusters can adopt an R4 fate in mutant eye imaginal discs.

(Rintelen et al., 2003)

Expression of sev^{S11.T:Hsap\MYC} causes a rough eye phenotype and a transformation of cone cells into additional R7 cells.

(Feller et al., 2002)

Flies carrying sev^{S11.T:Hsap\MYC} have an average of 2.5 ectopic R7 cells per ommatidium.

(Smith et al., 2002)

Mutants have abnormal eyes - ectopic R7 photoreceptors are in nearly all ommatidia.

(Ciapponi et al., 2001)

Expression of sev^{S11.T:Hsap\MYC} leads to the recruitment of supernumerary R7 photoreceptor cells, exhibiting a characteristic rough pattern of irregular ommatidia.

(Morey et al., 2001)

Expression of sev^{S11.T:Hsap\MYC} causes a rough eye phenotype due to the transformation of cone cells into additional R7 cells.

(Bausenwein et al., 2000)

Flies carrying sev^{S11.T:Hsap\MYC} have rough eyes, due to the transformation of cone cells into supernumerary photoreceptors, mainly R7 cells.

(Luschnig et al., 2000)

Flies carrying sev^{S11.T:Hsap\MYC} have an average of 3.38 +/- 0.26 R7 photoreceptor cells per ommatidium.

(Pazman et al., 2000)

sev^{S11.T:Hsap\MYC} mutant eyes do not exhibit melanotic tumours.

(Robertson et al., 2000)

Mutant flies have rough eyes.

(Herbst et al., 1999)

Flies carrying sev^{S11.T:Hsap\MYC} have rough eyes with disorganised morphology, due to the presence of multiple R7 cells per ommatidium and frequent ommatidial fusions.

(Le and Simon, 1998)

Flies carrying sev^{S11.T:Hsap\MYC} have a rough eye phenotype.

(Maixner et al., 1998)

Heterozygotes exhibit roughening of patches on both eyes. Homozygotes exhibit blistering in patches on one or both eyes. The major effect is the production of ectopic R7 photoreceptors up to a maximum of 4 per individual ommatidium. Mutation results in migration of ectopic photoreceptors beneath the basal membrane.

(Polaczyk et al., 1998)

Rough eye phenotype.

(Therrien et al., 1998)

Adults exhibit a rough eye phenotype that cannot be suppressed by heterozygosity for Jra (Jra^76-19).

(Hou et al., 1997)

Appearance of ectopic photoreceptor cells in the adult eye is suppressed by loss of a functional copy of Jra (Jra¹ or Jra^IA109).

(Kockel et al., 1997)

Su(Raf) Hsp83 mutations and Hsp83^e6D interact genetically with the sev mutations, other E(sev) Hsp83 mutations fail to interact.

(van der Straten et al., 1997)

Extra R7 phenotype is suppressed by mutations in lilli.

(Dickson et al., 1996)

Expression in stage 11 embryos does little harm to the developing tracheal system despite strong deleterious effects on viability. Expression at stage 13 induces numerous ectopic secondary or terminal branches.

(Lee et al., 1996)

Expression of P{sE-dos} restores the multiple R7 phenotype in sev^{S11.T:Hsap\MYC} heterozygotes.

(Raabe et al., 1996)

Overexpression of P{hs-argos.S} fails to inhibit the formation of multiple R7 cells.

(Sawamoto et al., 1996)

Supernumerary R7 cell formation. Injection of a Ras CAAX peptidomimetic, FTI-254, fails to rescue the mutant eye phenotype.

(Kauffmann et al., 1995)

Extra R7 cells formed in ommatidia.

(Kramer et al., 1995)

Rough eye phenotype is suppressed by Jra^{bZIP.hs.sev.T:Ivir\HA1}.

(Bohmann et al., 1994)

Flies expressing sev^{S11.T:Hsap\MYC} have rough eyes.

(Kussick et al., 1993)

Rough eyes.

(Olivier et al., 1993)

Transformation of mystery cells and cone cells into R7 cells (Basler et al., Cell 64:1069--1082 ).

(Dickson et al., 1992)

Rough eye, irregular ommatidial pattern. Most ommatidia have more than 6 photoreceptor cells, several of which have rhabdomeres characteristic of R7 cells. sev^{S11.T:Hsap\MYC}; ort double mutants exhibit 4 small rhabdomeres per ommatidium. sev¹⁴, sev^{S11.T:Hsap\MYC} flies are attracted to UV light suggesting that some of the supernumerary R7-like cells make functional synaptic connections.

(Basler et al., 1991)

Flies carrying sev^{S11.T:Hsap\MYC} in a sev mutant background have rough eyes. Each ommatidium contains on average 6 large rhabdomeres and 4 small rhabdomeres.

(Hafen and Basler, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, enhanceable by drk^EP2477/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

sev^S11.Tag:MYC has visible | dominant phenotype, enhanceable by Dab^{ΔPro.hs.2sev}

(Le and Simon, 1998)

sev^S11.Tag:MYC has lethal | embryonic stage phenotype, enhanceable by Ras85D^V12.sev

(Maixner et al., 1998)

Suppressed by

Statement

Reference

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, suppressible by Socs36E^34-120y+/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, suppressible by Socs36E^34-120y-/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4^hs.2sev/Socs36E^ΔSB.UASp

(Almudi et al., 2009)

sev^S11.Tag:MYC has visible phenotype, suppressible by cdi^33-077/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4^hs.2sev/cdi^34-165

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible by cdi^44-004/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4^hs.2sev/cdi^34-165y-

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible by mRpL55^UAS.cSa/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible by cdi^44-004y-/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, suppressible | partially by mask[+]/mask^5.8

(Smith et al., 2002)

sev^S11.Tag:MYC has visible phenotype, suppressible | partially by mask[+]/mask^10.22

(Smith et al., 2002)

sev^S11.Tag:MYC has visible phenotype, suppressible | partially by Sps1^k11320

(Morey et al., 2001)

sev^S11.Tag:MYC has visible phenotype, suppressible | partially by Egfr^f2

(Luschnig et al., 2000)

sev^S11.Tag:MYC has visible | dominant phenotype, suppressible by Nrt^unspecified

(Le and Simon, 1998)

sev^S11.Tag:MYC has visible | dominant phenotype, suppressible by Dab^{S119A.hs.2sev}

(Le and Simon, 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)04708⁰⁴⁷⁰⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)06743⁰⁶⁷⁴³

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)06734⁰⁶⁷³⁴

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by sr^06948b/l(3)06948a^06948a

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Dl^03745b/tws^03745a

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)04704b^04704b/l(3)04704a^04704a

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Ras85D^E4

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Trl⁶²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by trx^unspecified

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(2L)JK12

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by skd²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by osa²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by mor¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by kto¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by kis¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by kis²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by brm¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by brm²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(3R)red-P52

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Polr2B^AS

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Polr2I^V

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by SR3-8^XS-701

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by SR3-8^S-959

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by SR3-7^XS-17N

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by SR3-7^S-499

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Taf1^XS-2232

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Taf1^S-625

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Su(Tpl)^S-705

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Su(Tpl)^S-192

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Taf4^S-466

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Taf4^XS-793

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Taf6^XS-922

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Sos^e4G

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by rl^XS-2275

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by rl^XS-2442

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by ksr^XS-2424

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by ksr^XS-2832

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by phyl²⁸²⁹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by phyl²²⁴⁵

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by βggt-I^S-2554

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by mam^S-176

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(3R)293γ5

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(2L)ast2

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(2R)nap9

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(2R)pk78c

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Df(3L)vin2

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Ras85D^e1B

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Psa⁰⁶²⁴⁰

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)06265⁰⁶²⁶⁵

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)09291⁰⁹²⁹¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by HDAC1⁰⁴⁵⁵⁶

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)05143⁰⁵¹⁴³

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by btl⁰⁰²⁰⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by btl⁰⁴⁷²⁷

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by frc¹⁰⁰⁹⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by ftz-f1⁰³⁶⁴⁹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by eRF1⁰⁵⁶³⁷

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by Pss⁰⁴⁵²¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by tws⁰²⁴¹⁴

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by tws⁰⁶⁸⁴⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)03608⁰³⁶⁰⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)06658⁰⁶⁶⁵⁸

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by osa⁰⁴⁵³⁹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by fray⁰⁷⁵⁵¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)05820⁰⁵⁸²⁰

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by InR⁰⁵⁵⁴⁵

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by pnt^04263b

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by pnt⁰⁷⁸²⁵

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, suppressible by l(3)03077⁰³⁰⁷⁷

(Maixner et al., 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has visible phenotype, non-suppressible by Socs36E^SH2.UASp/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by cdi^33-077

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by cdi^34-165

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by cdi^44-004

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by cdi^33-077y-/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by Shc^BG

(Luschnig et al., 2000)

sev^S11.Tag:MYC has visible phenotype, non-suppressible by Shc^111-40

(Luschnig et al., 2000)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by TfIIA-S^E32

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by ash1²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Vha55¹⁵

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Vha55¹⁶

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by mor²

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by osa¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by sls¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by skd¹

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Df(3R)urd

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Nsf2^urd-2

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by vtd³

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Pc³

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC has lethal phenotype, non-suppressible by Pc⁴

(Maixner et al., 1998)

Other

Statement

Reference

Cbl^Dv.UAS, Scer\GAL4^en-e16E, sev^S11.Tag:MYC has hyperplasia phenotype

(Robertson et al., 2000)

ro^sev.PI, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)05143⁰⁵¹⁴³, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, btl⁰⁰²⁰⁸, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, btl⁰⁴⁷²⁷, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, frc¹⁰⁰⁹⁸, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, ftz-f1⁰³⁶⁴⁹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

phyl^hs.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, eRF1⁰⁵⁶³⁷, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Pss⁰⁴⁵²¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC, tws⁰²⁴¹⁴ has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC, tws⁰⁶⁸⁴⁸ has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)03608⁰³⁶⁰⁸, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)06658⁰⁶⁶⁵⁸, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, osa⁰⁴⁵³⁹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, fray⁰⁷⁵⁵¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)05820⁰⁵⁸²⁰, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

InR⁰⁵⁵⁴⁵, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Trl⁶², sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, pnt^04263b, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, pnt⁰⁷⁸²⁵, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)03077⁰³⁰⁷⁷, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)04708⁰⁴⁷⁰⁸, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)06743⁰⁶⁷⁴³, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)06734⁰⁶⁷³⁴, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)06948a^06948a, sev^S11.Tag:MYC, sr^06948b has viable phenotype

(Maixner et al., 1998)

Dl^03745b, Ras85D^V12.sev, sev^S11.Tag:MYC, tws^03745a has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)04704a^04704a, l(3)04704b^04704b, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC, trx^unspecified has viable phenotype

(Maixner et al., 1998)

Df(2L)JK12, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, sev^S11.Tag:MYC, skd² has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, osa², sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, mor¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, kto¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, kis¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, kis², sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^N17.hs.2sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, brm¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, brm², sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(3R)red-P52, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Polr2B^AS, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Polr2I^V, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, SR3-8^XS-701, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, SR3-8^S-959, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, SR3-7^XS-17N, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, SR3-7^S-499, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Taf1^XS-2232, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^E4, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Taf1^S-625, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Su(Tpl)^S-705, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Su(Tpl)^S-192, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Taf4^S-466, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Taf4^XS-793, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Taf6^XS-922, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Sos^e4G, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, rl^XS-2275, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, rl^XS-2442, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, ksr^XS-2424, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

aop^ACT.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, ksr^XS-2832, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, phyl²⁸²⁹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, phyl²²⁴⁵, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

βggt-I^S-2554, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, mam^S-176, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(3R)293γ5, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(2L)ast2, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(2R)nap9, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(2R)pk78c, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Df(3L)vin2, Ras85D^V12.sev, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

phyl^sev.PC, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Ras85D^e1B, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, Psa⁰⁶²⁴⁰, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)06265⁰⁶²⁶⁵, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, l(3)09291⁰⁹²⁹¹, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Ras85D^V12.sev, HDAC1⁰⁴⁵⁵⁶, sev^S11.Tag:MYC has viable phenotype

(Maixner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

sev^S11.Tag:MYC has eye phenotype, enhanceable by drk^EP2477/Scer\GAL4^hs.2sev

(Almudi et al., 2010)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, enhanceable by drk^EP2477/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, enhanceable by drk^EP2477/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

dos^R31, sev^S11.Tag:MYC has photoreceptor cell R7 phenotype, enhanceable by dos::Hsap\GAB1^hs.2sev.GFP

(Bausenwein et al., 2000)

sev^S11.Tag:MYC has eye phenotype, enhanceable by dos^hs.2sev.cHa

(Herbst et al., 1999)

sev^S11.Tag:MYC has ommatidium phenotype, enhanceable by dos^YY.hs.2sev

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, enhanceable by dos^YY.hs.2sev

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, enhanceable by Dab^{ΔPro.hs.2sev}

(Le and Simon, 1998)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, enhanceable by Dab^{ΔPro.hs.2sev}

(Le and Simon, 1998)

NOT Enhanced by

Statement

Reference

sev^S11.Tag:MYC has phenotype, non-enhanceable by lilli^s35

(Tang et al., 2001)

sev^S11.Tag:MYC has phenotype, non-enhanceable by lilli^XS407/lilli^XS407

(Tang et al., 2001)

sev^S11.Tag:MYC has phenotype, non-enhanceable by lilli^XS575

(Tang et al., 2001)

Suppressed by

Statement

Reference

sev^S11.Tag:MYC has eye phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2010)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, suppressible by Socs36E^34-120y+/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, suppressible by Socs36E^34-120y-/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible by Socs36E^UASp.cCa/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4^hs.2sev/Socs36E^ΔSB.UASp

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible | partially by Scer\GAL4^hs.2sev/Socs36E^ΔSB.UASp

(Almudi et al., 2009)

sev^S11.Tag:MYC has eye photoreceptor cell | increased number phenotype, suppressible by Scer\GAL4^hs.2sev/S6kII^UAS.Tag:MYC

(Kim et al., 2006)

sev^S11.Tag:MYC has eye photoreceptor cell | increased number phenotype, suppressible by S6kII^{K231R.UAS.Tag:MYC}/Scer\GAL4^hs.2sev

(Kim et al., 2006)

sev^S11.Tag:MYC has eye phenotype, suppressible by cdi^33-077/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4^hs.2sev/cdi^34-165

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, suppressible by cdi^44-004/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4^hs.2sev/cdi^34-165y-

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, suppressible by mRpL55^UAS.cSa/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by cdi^UAS.cSa/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by ssh^{dsRNA.UAS.GFP}/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by tsr^ntf/tsr²

(Sese et al., 2006)

sev^S11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible by Mkp3^hs.sev

(Rintelen et al., 2003)

sev^S11.Tag:MYC has cone cell phenotype, suppressible by dos^R31

(Feller et al., 2002)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by dos^R31

(Feller et al., 2002)

sev^S11.Tag:MYC has eye phenotype, suppressible by dos^R31

(Feller et al., 2002)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by mask[+]/mask^5.8

(Smith et al., 2002)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by mask[+]/mask^10.22

(Smith et al., 2002)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by kay²

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by kay²

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by kay^C-Ala.UAS/Scer\GAL4^unspecified

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by kay^C-Ala.UAS/Scer\GAL4^unspecified

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by Scer\GAL4^unspecified/kay^pan-Ala.UAS

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Scer\GAL4^unspecified/kay^pan-Ala.UAS

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has eye phenotype, suppressible | partially by Sps1^k11320

(Morey et al., 2001)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible | partially by Sps1^k11320

(Morey et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by Sps1^k11320

(Morey et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell phenotype, suppressible | partially by Sps1^k11320

(Morey et al., 2001)

sev^S11.Tag:MYC has eye phenotype, suppressible | partially by Catⁿ¹

(Morey et al., 2001)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible | partially by Catⁿ¹

(Morey et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible | partially by Catⁿ¹

(Morey et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell phenotype, suppressible | partially by Catⁿ¹

(Morey et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 phenotype, suppressible by dos^P115

(Bausenwein et al., 2000)

sev^S11.Tag:MYC has photoreceptor cell R7 phenotype, suppressible by dos^R31

(Bausenwein et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible | partially by Egfr^f2

(Luschnig et al., 2000)

sev^S11.Tag:MYC has eye phenotype, suppressible | partially by Egfr^f2

(Luschnig et al., 2000)

sev^S11.Tag:MYC has phenotype, suppressible by rin¹/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by rin¹/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by rin¹/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has phenotype, suppressible by rin²/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by rin²/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by rin²/rin[+]

(Pazman et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by dos^{Y801F.hs.2sev.cHa}

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, suppressible by dos^{Y801F.hs.2sev.cHa}

(Herbst et al., 1999)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by dos^{Y810F.Y854F.hs.2sev}

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, suppressible by dos^{Y810F.Y854F.hs.2sev}

(Herbst et al., 1999)

sev^S11.Tag:MYC has ommatidium phenotype, suppressible by dos^{Y854F.hs.2sev}

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, suppressible by dos^{Y854F.hs.2sev}

(Herbst et al., 1999)

sev^S11.Tag:MYC has eye phenotype, suppressible by Nrt^unspecified

(Le and Simon, 1998)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Nrt^unspecified

(Le and Simon, 1998)

sev^S11.Tag:MYC has eye phenotype, suppressible by Dab^{S119A.hs.2sev}

(Le and Simon, 1998)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Dab^{S119A.hs.2sev}

(Le and Simon, 1998)

sev^S11.Tag:MYC has eye phenotype, suppressible by cnk^XE-1040

(Therrien et al., 1998)

sev^S11.Tag:MYC has eye photoreceptor cell phenotype, suppressible by Jra¹/Jra[+]

(Kockel et al., 1997)

sev^S11.Tag:MYC has eye photoreceptor cell phenotype, suppressible by Jra^IA109/Jra[+]

(Kockel et al., 1997)

sev^S11.Tag:MYC has phenotype, suppressible by dos^1.46

(Herbst et al., 1996)

sev^S11.Tag:MYC has phenotype, suppressible by dos^2.42

(Herbst et al., 1996)

sev^S11.Tag:MYC has phenotype, suppressible by dos^unspecified

(Herbst et al., 1996)

sev^S11.Tag:MYC has phenotype, suppressible by dos^R31

(Raabe et al., 1996)

sev^S11.Tag:MYC has phenotype, suppressible by dos^P115

(Raabe et al., 1996)

sev^S11.Tag:MYC has eye phenotype, suppressible by TfIIA-S^E73

(Zeidler et al., 1996)

NOT suppressed by

Statement

Reference

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has eye phenotype, non-suppressible by Socs36E^SH2.UASp/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Scer\GAL4^hs.2sev, sev^S11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, non-suppressible by Socs36E^SH2.UASp/Scer\GAL4^hs.2sev

(Almudi et al., 2009)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by cdi^33-077

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by cdi^34-165

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by cdi^44-004

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by cdi^33-077y-/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by cdi^44-004y-/Scer\GAL4^hs.2sev

(Sese et al., 2006)

sev^S11.Tag:MYC has ommatidium phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, non-suppressible by kay^hs.PZ/kay²

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has ommatidium phenotype, non-suppressible by Scer\GAL4^unspecified/kay^N-Ala.UAS

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, non-suppressible by Scer\GAL4^unspecified/kay^N-Ala.UAS

(Ciapponi et al., 2001)

sev^S11.Tag:MYC has phenotype, non-suppressible by lilli^XS407/lilli^XS407

(Tang et al., 2001)

sev^S11.Tag:MYC has phenotype, non-suppressible by lilli^XS575

(Tang et al., 2001)

sev^S11.Tag:MYC has phenotype, non-suppressible by lilli^s35

(Tang et al., 2001)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by Shc^BG

(Luschnig et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, non-suppressible by Shc^BG

(Luschnig et al., 2000)

sev^S11.Tag:MYC has eye phenotype, non-suppressible by Shc^111-40

(Luschnig et al., 2000)

sev^S11.Tag:MYC has ommatidium phenotype, non-suppressible by Shc^111-40

(Luschnig et al., 2000)

sev^S11.Tag:MYC has phenotype, non-suppressible by vap^UAS.Tag:MYC/Scer\GAL4^hs.2sev

(Feldmann et al., 1999)

Enhancer of

Statement

Reference

sev^S11.Tag:MYC is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

sev^S11.Tag:MYC is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

Other

Statement

Reference

Scer\GAL4^hs.2sev, Socs36E^UASp.cCa, drk^EP2477, sev^S11.Tag:MYC has eye phenotype

(Almudi et al., 2010)

lilli^3E8, sev^S11.Tag:MYC has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of drk^EP2477 under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background results in a strong rough eye phenotype.

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background rescues the rough-eye phenotype.

Expression of drk^EP2477 and Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background results in an intermediate rough-eye phenotype.

(Almudi et al., 2010)

Co-expression of either Socs36E^34-120y+ or Socs36E^34-120y- suppresses the rough eye phenotype caused by expression of sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

Co-expression of Socs36E^{Scer\UAS.P\T.cCa} suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

Expression of drk^EP2477 under the control of Scer\GAL4^hs.2sev enhances the rough eye and extra R7 photoreceptor cell phenotype caused by sev^{S11.T:Hsap\MYC}.

Co-expression of Socs36E^{SH2.Scer\UAS.P\T} does not suppress the rough eye or extra R7 photoreceptor cell phenotype caused by expression of sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

Co-expression of Socs36E^{ΔSB.Scer\UAS.P\T} suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

(Almudi et al., 2009)

The increased photoreceptor cell phenotype seen in sev^{S11.T:Hsap\MYC} flies is suppressed when flies coexpress either S6kII^{Scer\UAS.T:Hsap\MYC} or S6kII^{K231R.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

(Kim et al., 2006)

Expression of either cdi^33-077, cdi^34-165 or cdi^44-004 under the control of Scer\GAL4^hs.2sev suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC} flies. In the absence of the Scer\GAL4^hs.2sev driver, no suppression is seen.

Expression of either cdi^34-165y- or cdi^44-004y- under the control of Scer\GAL4^hs.2sev suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC} flies.

Expression of cdi^33-077y- under the control of Scer\GAL4^hs.2sev does not suppress the rough eye phenotype of sev^{S11.T:Hsap\MYC} flies.

Expression of cdi^Scer\UAS.cSa under the control of Scer\GAL4^hs.2sev partially suppresses the extra R7 photoreceptor cell phenotype of sev^{S11.T:Hsap\MYC} flies.

Expression of mRpL55^Scer\UAS.cSa under the control of Scer\GAL4^hs.2sev does not suppress the eye phenotype of sev^{S11.T:Hsap\MYC} flies.

Expression of ssh^{dsRNA.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^hs.2sev partially suppresses the extra R7 photoreceptor cell phenotype of sev^{S11.T:Hsap\MYC} flies.

tsr²/tsr^ntf weakly suppresses the extra R7 photoreceptor cell phenotype of sev^{S11.T:Hsap\MYC} flies.

(Sese et al., 2006)

Co-expression of Mkp3^hs.sev almost completely suppresses the extra R7 photoreceptor cell phenotype seen in flies expressing sev^{S11.T:Hsap\MYC}.

(Rintelen et al., 2003)

The addition of dos^R31 almost completely suppresses the rough eye phenotype seen in sev^{S11.T:Hsap\MYC} animals. The addition of both dos^R31 and dos^hs.2sev does not suppress the phenotype. The addition of both dos^R31 and dos^{R644K.R696K.hs.2sev} or dos^{R696K.hs.2sev} continues to suppress the rough eye phenotype. The addition of both dos^{R644K.hs.2sev} partially suppresses the rough eye phenotype.

(Feller et al., 2002)

mask^10.22 dominantly suppresses the ectopic R7 phenotype caused by sev^{S11.T:Hsap\MYC}; the double mutant flies have an average of 1.8 ectopic R7 cells per ommatidium. mask^5.8 dominantly suppresses the ectopic R7 phenotype caused by sev^{S11.T:Hsap\MYC}; the double mutant flies have an average of 1.9 ectopic R7 cells per ommatidium.

(Smith et al., 2002)

When SelD^k11320 is added to sev^{S11.T:Hsap\MYC} flies, there is an increase of wild-type ommatidia from less than 10% to more than 50%. Only 7.5% of ommatidia in sev^{S11.T:Hsap\MYC} eyes contain one R7 cell, the addition of SelD^k11320 increases that to 61.2%. The addition of Catⁿ¹ also suppresses these phenotypes.

(Morey et al., 2001)

The addition of heterozygous dos^R31 or dos^P115 largely suppresses the sev^{S11.T:Hsap\MYC} rough eye phenotype. The addition of dos^{hs.T:Avic\GFP} to dos^R31/sev^{S11.T:Hsap\MYC} flies restores the multiple R7 phenotype.

(Bausenwein et al., 2000)

The extra R7 photoreceptor cells seen in flies carrying sev^{S11.T:Hsap\MYC} are reduced to an average of 2.71 +/- 0.23 or 2.32 +/- 0.11 R7 photoreceptor cells per ommatidium if the flies are also carrying rin¹ or rin² respectively.

(Pazman et al., 2000)

Expression of Cbl^Dv.Scer\UAS in the eye under the control of Scer\GAL4^GMR.PF in combination with sev^{S11.T:Hsap\MYC} at 29[o]C produces melanotic tumours in the eyes in approximately 40% of progeny.

(Robertson et al., 2000)

vap^{Scer\UAS.T:Hsap\MYC} does not suppress the sev^{S11.T:Hsap\MYC} phenotype when expressed under the control of Scer\GAL4^hs.2sev.

(Feldmann et al., 1999)

The sev^{S11.T:Hsap\MYC} rough eye phenotype is dominantly suppressed by Nrt^unspecified or Dab^{S119A.hs.2sev} and is enhanced by Dab^{ΔPro.hs.2sev}.

(Le and Simon, 1998)

Ras85D^V12.sev in combination with sev^{S11.T:Hsap\MYC} results in synthetic lethality. Expression of sev^{S11.T:Hsap\MYC} above a certain level in embryos results in lethality and this lethality is enhanced by co-expression of Ras85D^V12.sev. The lethality is sensitive to the expression levels of both sev^{S11.T:Hsap\MYC} and Ras85D^V12.sev. Less than 10% of sev^{S11.T:Hsap\MYC} Ras85D^V12.sev embryos form cuticle. Those embryos that do form cuticle generally have missing or malformed anterior structures including head parts and thoracic segments, as marked by absence of denticle belts. Approximately one-third of the embryos show curling of the cuticle, possibly due to a failure in germband retraction, and approximately one-tenth of embryos have a weak dorsal closure phenotype. A small fraction of embryos have missing or fused abdominal denticle belts, swollen anterior segments or completely lack identifiable structures and form a ball of cuticle. sev^{S11.T:Hsap\MYC} embryos show a similar range of phenotypes. sev^{S11.T:Hsap\MYC} is not lethal in combination with phyl^sev.PC, ro^sev.PI, aop^ACT.sev, phyl^hs.sev or Ras85D^N17.hs.2sev. The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by Trl⁶², trx^unspecified, Df(2L)JK12, skd², osa², mor¹, kto¹, kis¹, kis², brm¹, brm², Df(3R)red-P52, RpII140^AS, RpII15^V, SR3-8^XS-701, SR3-8^S-959, SR3-7^XS-17N, SR3-7^S-499, Taf1^XS-2232, Taf1^S-625, Su(Tpl)^S-705, Su(Tpl)^S-192, Taf4^S-466, Taf4^XS-793, Taf6^XS-922, Sos^e4G, Ras85D^e1B, Ras85D^E4, rl^XS-2275, rl^XS-2442, ksr^XS-2424, ksr^XS-2832, phyl²⁸²⁹, phyl²²⁴⁵, βggt-I^S-2554, mam^S-176, Df(3R)293γ5, Df(2L)ast2, Df(2R)nap9, Df(2R)pk78c or Df(3L)vin2. The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by l(3)06240⁰⁶²⁴⁰, l(3)06265⁰⁶²⁶⁵, l(3)09291⁰⁹²⁹¹, Rpd3⁰⁴⁵⁵⁶, l(3)05143⁰⁵¹⁴³, btl⁰⁰²⁰⁸, btl⁰⁴⁷²⁷, frc¹⁰⁰⁹⁸, ftz-f1⁰³⁶⁴⁹, eRF1⁰⁵⁶³⁷, l(3)77CDf⁰⁴⁵²¹, tws⁰²⁴¹⁴, tws⁰⁶⁸⁴⁸, l(3)03608⁰³⁶⁰⁸, l(3)06658⁰⁶⁶⁵⁸, osa⁰⁴⁵³⁹, fray⁰⁷⁵⁵¹, l(3)05820⁰⁵⁸²⁰, InR⁰⁵⁵⁴⁵, pnt^04263b, pnt⁰⁷⁸²⁵, l(3)03077⁰³⁰⁷⁷, l(3)04708⁰⁴⁷⁰⁸, l(3)06743⁰⁶⁷⁴³ or l(3)06734⁰⁶⁷³⁴. The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is suppressed by the l(3)06948 line (l(3)06948a^06948a and sr^06948b), by the l(3)03745 line (tws^03745a and Dl^03745b) and by the l(3)04704 line (l(3)04704a^04704a and l(3)04704b^04704b). The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is not suppressed by TfIIA-S^E32, ash1², Vha55¹⁵, Vha55¹⁶, mor², osa¹, sls¹, skd¹, Df(3R)urd, urd², vtd³, Pc³ or Pc⁴.

(Maixner et al., 1998)

TfIIA-S^E73 suppresses the rough eye phenotype of sev^{S11.T:Hsap\MYC}, phl::tor^12D.hs.sev, Ras85D^V12.sev, rl^Sem and svp^2.sev.

(Zeidler et al., 1996)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

10642

w¹¹¹⁸ sev¹⁴ P{sev5}S11.1

Notes on Origin

Discoverer

Comments

The number of ectopic R7 cells is highly sensitive to the wild-type genetic background.

(Polaczyk et al., 1998)

Constitutively activated sev kinase.

(Dickson et al., 1992)

Ligand independent allele.

(Kramer et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Sev^S11.1

(Polaczyk and Gibson, 1997)

Sev^S11

(Rintelen et al., 2001, Herbst et al., 1999, Rintelen et al., 1999, Maixner et al., 1998, Thomas et al., 1998, Lim et al., 1997, Dickson et al., 1996, Hafen et al., 1993, Basler and Hafen, 1991)

Sev^s11

(Mora et al., 2013, Luschnig et al., 2000)

sev^S11.1

(Hou et al., 1997)

sev^{S11.T:Hsap\MYC}

sev^S11.T:Myc

sev^S11.Tag:MYC

sev^s11

(Kim et al., 2006, Venkatesh, 1993)

Name Synonyms

Secondary FlyBase IDs

References (59)

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