A truncated, activated sevenless kinase overexpressed under the control of a duplicated sev enhancer.
sev amino acids 1865 to 2554, lacking most of the extracellular domain, encoded by cDNA are under the control of the duplicated sev enhancer and Hsp70 promoter. N-terminal signal sequence is provided by an inframe fusion with the signal peptide of Lcp3, and the protein is tagged with a Tag:MYC epitope.
Flies expressing sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev have a rough eye phenotype. Extra R7 photoreceptor cells are present in the ommatidia.
The eyes of flies that express sevS11.T:Hsap\MYC show a greater number of photoreceptor cells per ommatidium than wild-type flies.
Flies carrying sevS11.T:Hsap\MYC have a rough eye phenotype, with an average of 4.3 R7 cells per ommatidium.
Flies expressing sevS11.T:Hsap\MYC have extra R7 photoreceptors in the eye and occasionally have extra outer photoreceptor cells. Cells outside the ommatidial preclusters can adopt an R4 fate in mutant eye imaginal discs.
Expression of sevS11.T:Hsap\MYC causes a rough eye phenotype and a transformation of cone cells into additional R7 cells.
Flies carrying sevS11.T:Hsap\MYC have an average of 2.5 ectopic R7 cells per ommatidium.
Mutants have abnormal eyes - ectopic R7 photoreceptors are in nearly all ommatidia.
Expression of sevS11.T:Hsap\MYC leads to the recruitment of supernumerary R7 photoreceptor cells, exhibiting a characteristic rough pattern of irregular ommatidia.
Expression of sevS11.T:Hsap\MYC causes a rough eye phenotype due to the transformation of cone cells into additional R7 cells.
Flies carrying sevS11.T:Hsap\MYC have rough eyes, due to the transformation of cone cells into supernumerary photoreceptors, mainly R7 cells.
Flies carrying sevS11.T:Hsap\MYC have an average of 3.38 +/- 0.26 R7 photoreceptor cells per ommatidium.
sevS11.T:Hsap\MYC mutant eyes do not exhibit melanotic tumours.
Mutant flies have rough eyes.
Flies carrying sevS11.T:Hsap\MYC have rough eyes with disorganised morphology, due to the presence of multiple R7 cells per ommatidium and frequent ommatidial fusions.
Flies carrying sevS11.T:Hsap\MYC have a rough eye phenotype.
Heterozygotes exhibit roughening of patches on both eyes. Homozygotes exhibit blistering in patches on one or both eyes. The major effect is the production of ectopic R7 photoreceptors up to a maximum of 4 per individual ommatidium. Mutation results in migration of ectopic photoreceptors beneath the basal membrane.
Rough eye phenotype.
Extra R7 phenotype is suppressed by mutations in lilli.
Expression in stage 11 embryos does little harm to the developing tracheal system despite strong deleterious effects on viability. Expression at stage 13 induces numerous ectopic secondary or terminal branches.
Expression of P{sE-dos} restores the multiple R7 phenotype in sevS11.T:Hsap\MYC heterozygotes.
Overexpression of P{hs-argos.S} fails to inhibit the formation of multiple R7 cells.
Supernumerary R7 cell formation. Injection of a Ras CAAX peptidomimetic, FTI-254, fails to rescue the mutant eye phenotype.
Extra R7 cells formed in ommatidia.
Rough eye phenotype is suppressed by JrabZIP.hs.sev.T:Ivir\HA1.
Flies expressing sevS11.T:Hsap\MYC have rough eyes.
Rough eyes.
Transformation of mystery cells and cone cells into R7 cells (Basler et al., Cell 64:1069--1082 ).
Rough eye, irregular ommatidial pattern. Most ommatidia have more than 6 photoreceptor cells, several of which have rhabdomeres characteristic of R7 cells. sevS11.T:Hsap\MYC; ort double mutants exhibit 4 small rhabdomeres per ommatidium. sev14, sevS11.T:Hsap\MYC flies are attracted to UV light suggesting that some of the supernumerary R7-like cells make functional synaptic connections.
Flies carrying sevS11.T:Hsap\MYC in a sev mutant background have rough eyes. Each ommatidium contains on average 6 large rhabdomeres and 4 small rhabdomeres.
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, enhanceable by drkEP2477/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible | dominant phenotype, enhanceable by DabΔPro.hs.2sev
sevS11.Tag:MYC has lethal | embryonic stage phenotype, enhanceable by Ras85DV12.sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, suppressible by Socs36E34-120y+/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, suppressible by Socs36E34-120y-/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, suppressible by Socs36EUASp.cCa/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4hs.2sev/Socs36EΔSB.UASp
sevS11.Tag:MYC has visible phenotype, suppressible by cdi33-077/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4hs.2sev/cdi34-165
sevS11.Tag:MYC has visible phenotype, suppressible by cdi44-004/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, suppressible by Scer\GAL4hs.2sev/cdi34-165y-
sevS11.Tag:MYC has visible phenotype, suppressible by cdi44-004y-/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, suppressible by mRpL55UAS.cSa/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, suppressible by mask[+]/mask5.8
sevS11.Tag:MYC has visible phenotype, suppressible by mask[+]/mask10.22
sevS11.Tag:MYC has visible phenotype, suppressible by Sps1k11320
sevS11.Tag:MYC has visible phenotype, suppressible by Egfrf2
sevS11.Tag:MYC has visible | dominant phenotype, suppressible by Nrtunspecified
sevS11.Tag:MYC has visible | dominant phenotype, suppressible by DabS119A.hs.2sev
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0470804708
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0674306743
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0673406734
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by sr06948b/l(3)06948a06948a
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Delta03745b/tws03745a
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)04704b04704b/l(3)04704a04704a
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Ras85De1B
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Ras85DE4
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Trl62
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by trxunspecified
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(2L)JK12
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by skd2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by osa2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by mor1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by kto1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by kis1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by kis2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by brm1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by brm2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(3R)red-P52
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Polr2BAS
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Polr2IV
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by SR3-8XS-701
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by SR3-8S-959
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by SR3-7XS-17N
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by SR3-7S-499
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Taf1XS-2232
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Taf1S-625
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Su(Tpl)S-705
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Su(Tpl)S-192
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Taf4S-466
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Taf4XS-793
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Taf6XS-922
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Sose4G
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by rlXS-2275
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by rlXS-2442
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by ksrXS-2424
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by ksrXS-2832
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by phyl2829
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by phyl2245
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by βggt-IS-2554
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by mamS-176
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(3R)293γ5
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(2L)ast2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(2R)nap9
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(2R)pk78c
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Df(3L)vin2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Psa06240
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0626506265
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0929109291
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by HDAC104556
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0514305143
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by btl00208
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by btl04727
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by frc10098
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by ftz-f103649
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by eRF105637
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by Pss04521
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by tws02414
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by tws06848
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0360803608
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0665806658
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by osa04539
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by fray07551
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0582005820
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by InR05545
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by pnt04263b
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by pnt07825
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, suppressible by l(3)0307703077
Scer\GAL4hs.2sev, sevS11.Tag:MYC has visible phenotype, non-suppressible by Socs36ESH2.UASp/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, non-suppressible by cdi33-077
sevS11.Tag:MYC has visible phenotype, non-suppressible by cdi34-165
sevS11.Tag:MYC has visible phenotype, non-suppressible by cdi44-004
sevS11.Tag:MYC has visible phenotype, non-suppressible by cdi33-077y-/Scer\GAL4hs.2sev
sevS11.Tag:MYC has visible phenotype, non-suppressible by ShcBG
sevS11.Tag:MYC has visible phenotype, non-suppressible by Shc111-40
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by TfIIA-SE32
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by ash12
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by vtd3
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Pc3
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Pc4
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Vha5515
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Vha5516
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by mor2
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by osa1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by sls1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by skd1
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Df(3R)urd
Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Nsf2urd-2
CblDv.UAS, Scer\GAL4en-e16E, sevS11.Tag:MYC has hyperplasia phenotype
Ras85DV12.sev, Trl62, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, brm1, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, brm2, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Ras85De1B, sevS11.Tag:MYC has viable phenotype
Df(3R)red-P52, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Polr2BAS, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Polr2IV, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, SR3-8XS-701, sevS11.Tag:MYC has viable phenotype
Ras85DN17.hs.2sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, SR3-8S-959, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, SR3-7XS-17N, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, SR3-7S-499, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Taf1XS-2232, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, sevS11.Tag:MYC, trxunspecified has viable phenotype
Ras85DV12.sev, Taf1S-625, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Su(Tpl)S-705, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Su(Tpl)S-192, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Taf4S-466, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Taf4XS-793, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Taf6XS-922, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, Sose4G, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, rlXS-2275, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, rlXS-2442, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, ksrXS-2424, sevS11.Tag:MYC has viable phenotype
Df(2L)JK12, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, ksrXS-2832, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, phyl2829, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, phyl2245, sevS11.Tag:MYC has viable phenotype
βggt-IS-2554, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, mamS-176, sevS11.Tag:MYC has viable phenotype
Df(3R)293γ5, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Df(2L)ast2, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Df(2R)nap9, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Df(2R)pk78c, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Df(3L)vin2, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, sevS11.Tag:MYC, skd2 has viable phenotype
Psa06240, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0626506265, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0929109291, sevS11.Tag:MYC has viable phenotype
HDAC104556, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0514305143, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, btl00208, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, btl04727, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, frc10098, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, ftz-f103649, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, eRF105637, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, osa2, sevS11.Tag:MYC has viable phenotype
Pss04521, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, sevS11.Tag:MYC, tws02414 has viable phenotype
Ras85DV12.sev, sevS11.Tag:MYC, tws06848 has viable phenotype
Ras85DV12.sev, l(3)0360803608, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0665806658, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, osa04539, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, fray07551, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0582005820, sevS11.Tag:MYC has viable phenotype
InR05545, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, pnt04263b, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, mor1, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, pnt07825, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0307703077, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0470804708, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0674306743, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)0673406734, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, l(3)06948a06948a, sevS11.Tag:MYC, sr06948b has viable phenotype
Delta03745b, Ras85DV12.sev, sevS11.Tag:MYC, tws03745a has viable phenotype
Ras85DV12.sev, l(3)04704a04704a, l(3)04704b04704b, sevS11.Tag:MYC has viable phenotype
aopACT.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, kto1, sevS11.Tag:MYC has viable phenotype
phylhs.sev, sevS11.Tag:MYC has viable phenotype
phylsev.PC, sevS11.Tag:MYC has viable phenotype
rosev.PI, sevS11.Tag:MYC has viable phenotype
Ras85DE4, Ras85DV12.sev, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, kis1, sevS11.Tag:MYC has viable phenotype
Ras85DV12.sev, kis2, sevS11.Tag:MYC has viable phenotype
sevS11.Tag:MYC has eye phenotype, enhanceable by drkEP2477/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, enhanceable by drkEP2477/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, enhanceable by drkEP2477/Scer\GAL4hs.2sev
dosR31, sevS11.Tag:MYC has photoreceptor cell R7 phenotype, enhanceable by dos::Hsap\GAB1hs.2sev.GFP
sevS11.Tag:MYC has eye phenotype, enhanceable by doshs.2sev.cHa
sevS11.Tag:MYC has ommatidium phenotype, enhanceable by dosYY.hs.2sev
sevS11.Tag:MYC has eye phenotype, enhanceable by dosYY.hs.2sev
sevS11.Tag:MYC has eye phenotype, enhanceable by DabΔPro.hs.2sev
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, enhanceable by DabΔPro.hs.2sev
sevS11.Tag:MYC has phenotype, non-enhanceable by lillis35
sevS11.Tag:MYC has phenotype, non-enhanceable by lilliXS407
sevS11.Tag:MYC has phenotype, non-enhanceable by lilliXS575
sevS11.Tag:MYC has eye phenotype, suppressible by Socs36EUASp.cCa/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, suppressible by Socs36E34-120y+/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, suppressible by Socs36E34-120y-/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, suppressible by Socs36EUASp.cCa/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible by Socs36EUASp.cCa/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4hs.2sev/Socs36EΔSB.UASp
Scer\GAL4hs.2sev, sevS11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible | partially by Scer\GAL4hs.2sev/Socs36EΔSB.UASp
sevS11.Tag:MYC has eye photoreceptor cell | increased number phenotype, suppressible by Scer\GAL4hs.2sev/S6kIIUAS.Tag:MYC
sevS11.Tag:MYC has eye photoreceptor cell | increased number phenotype, suppressible by S6kIIK231R.UAS.Tag:MYC/Scer\GAL4hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by cdi33-077/Scer\GAL4hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4hs.2sev/cdi34-165
sevS11.Tag:MYC has eye phenotype, suppressible by cdi44-004/Scer\GAL4hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by Scer\GAL4hs.2sev/cdi34-165y-
sevS11.Tag:MYC has eye phenotype, suppressible by mRpL55UAS.cSa/Scer\GAL4hs.2sev
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by cdiUAS.cSa/Scer\GAL4hs.2sev
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by sshRNAi.UAS.cNa/Scer\GAL4hs.2sev
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by tsrntf/tsr2
sevS11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, suppressible by Mkp3hs.sev
sevS11.Tag:MYC has cone cell phenotype, suppressible by dosR31
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by dosR31
sevS11.Tag:MYC has eye phenotype, suppressible by dosR31
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by mask[+]/mask10.22
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by mask[+]/mask5.8
sevS11.Tag:MYC has ommatidium phenotype, suppressible by kay2
sevS11.Tag:MYC has ommatidium phenotype, suppressible by kayC-Ala.UAS/Scer\GAL4unspecified
sevS11.Tag:MYC has ommatidium phenotype, suppressible by Scer\GAL4unspecified/kaypan-Ala.UAS
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by kayC-Ala.UAS/Scer\GAL4unspecified
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Scer\GAL4unspecified/kaypan-Ala.UAS
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by kay2
sevS11.Tag:MYC has eye phenotype, suppressible by Catn1
sevS11.Tag:MYC has eye phenotype, suppressible by Sps1k11320
sevS11.Tag:MYC has ommatidium phenotype, suppressible by Catn1
sevS11.Tag:MYC has ommatidium phenotype, suppressible by Sps1k11320
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Catn1
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Sps1k11320
sevS11.Tag:MYC has photoreceptor neuron phenotype, suppressible by Catn1
sevS11.Tag:MYC has photoreceptor neuron phenotype, suppressible by Sps1k11320
sevS11.Tag:MYC has photoreceptor cell R7 phenotype, suppressible by dosP115
sevS11.Tag:MYC has photoreceptor cell R7 phenotype, suppressible by dosR31
sevS11.Tag:MYC has ommatidium phenotype, suppressible by Egfrf2
sevS11.Tag:MYC has eye phenotype, suppressible by Egfrf2
sevS11.Tag:MYC has phenotype, suppressible by rin1/rin[+]
sevS11.Tag:MYC has phenotype, suppressible by rin2/rin[+]
sevS11.Tag:MYC has ommatidium phenotype, suppressible by rin1/rin[+]
sevS11.Tag:MYC has ommatidium phenotype, suppressible by rin2/rin[+]
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by rin1/rin[+]
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by rin2/rin[+]
sevS11.Tag:MYC has ommatidium phenotype, suppressible by dosY801F.hs.2sev.cHa
sevS11.Tag:MYC has ommatidium phenotype, suppressible by dosY810F.Y854F.hs.2sev
sevS11.Tag:MYC has ommatidium phenotype, suppressible by dosY854F.hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by dosY801F.hs.2sev.cHa
sevS11.Tag:MYC has eye phenotype, suppressible by dosY810F.Y854F.hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by dosY854F.hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by Nrtunspecified
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by Nrtunspecified
sevS11.Tag:MYC has eye phenotype, suppressible by DabS119A.hs.2sev
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, suppressible by DabS119A.hs.2sev
sevS11.Tag:MYC has eye phenotype, suppressible by cnkXE-1040
sevS11.Tag:MYC has eye photoreceptor cell phenotype, suppressible by Jra1/Jra[+]
sevS11.Tag:MYC has eye photoreceptor cell phenotype, suppressible by JraIA109/Jra[+]
sevS11.Tag:MYC has phenotype, suppressible by dos1.46
sevS11.Tag:MYC has phenotype, suppressible by dos2.42
sevS11.Tag:MYC has phenotype, suppressible by dosunspecified
sevS11.Tag:MYC has phenotype, suppressible by dosP115
sevS11.Tag:MYC has phenotype, suppressible by dosR31
sevS11.Tag:MYC has eye phenotype, suppressible by TfIIA-SE73
Scer\GAL4hs.2sev, sevS11.Tag:MYC has eye phenotype, non-suppressible by Socs36ESH2.UASp/Scer\GAL4hs.2sev
Scer\GAL4hs.2sev, sevS11.Tag:MYC has photoreceptor cell R7 | increased number phenotype, non-suppressible by Socs36ESH2.UASp/Scer\GAL4hs.2sev
sevS11.Tag:MYC has eye phenotype, non-suppressible by cdi33-077
sevS11.Tag:MYC has eye phenotype, non-suppressible by cdi34-165
sevS11.Tag:MYC has eye phenotype, non-suppressible by cdi44-004
sevS11.Tag:MYC has eye phenotype, non-suppressible by cdi33-077y-/Scer\GAL4hs.2sev
sevS11.Tag:MYC has eye phenotype, non-suppressible by cdi44-004y-/Scer\GAL4hs.2sev
sevS11.Tag:MYC has ommatidium phenotype, non-suppressible by kayhs.PZ/kay2
sevS11.Tag:MYC has ommatidium phenotype, non-suppressible by Scer\GAL4unspecified/kayN-Ala.UAS
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, non-suppressible by kayhs.PZ/kay2
sevS11.Tag:MYC has photoreceptor cell R7 | ectopic phenotype, non-suppressible by Scer\GAL4unspecified/kayN-Ala.UAS
sevS11.Tag:MYC has phenotype, non-suppressible by lilliXS407
sevS11.Tag:MYC has phenotype, non-suppressible by lillis35
sevS11.Tag:MYC has phenotype, non-suppressible by lilliXS575
sevS11.Tag:MYC has eye phenotype, non-suppressible by ShcBG
sevS11.Tag:MYC has ommatidium phenotype, non-suppressible by ShcBG
sevS11.Tag:MYC has eye phenotype, non-suppressible by Shc111-40
sevS11.Tag:MYC has ommatidium phenotype, non-suppressible by Shc111-40
sevS11.Tag:MYC has phenotype, non-suppressible by vapUAS.Tag:MYC/Scer\GAL4hs.2sev
sevS11.Tag:MYC is an enhancer of phenotype of svp1.sev
sevS11.Tag:MYC is an enhancer of phenotype of svp2.sev
Scer\GAL4hs.2sev, Socs36EUASp.cCa, drkEP2477, sevS11.Tag:MYC has eye phenotype
lilli3E8, sevS11.Tag:MYC has photoreceptor cell R7 phenotype
Expression of drkEP2477 under the control of Scer\GAL4hs.2sev in a sevS11.T:Hsap\MYC genetic background results in a strong rough eye phenotype.
Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4hs.2sev in a sevS11.T:Hsap\MYC genetic background rescues the rough-eye phenotype.
Expression of drkEP2477 and Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4hs.2sev in a sevS11.T:Hsap\MYC genetic background results in an intermediate rough-eye phenotype.
Co-expression of either Socs36E34-120y+ or Socs36E34-120y- suppresses the rough eye phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.
Co-expression of Socs36EScer\UAS.P\T.cCa suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.
Expression of drkEP2477 under the control of Scer\GAL4hs.2sev enhances the rough eye and extra R7 photoreceptor cell phenotype caused by sevS11.T:Hsap\MYC.
Co-expression of Socs36ESH2.Scer\UAS.P\T does not suppress the rough eye or extra R7 photoreceptor cell phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.
Co-expression of Socs36EΔSB.Scer\UAS.P\T suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sevS11.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.
The increased photoreceptor cell phenotype seen in sevS11.T:Hsap\MYC flies is suppressed when flies coexpress either S6kIIScer\UAS.T:Hsap\MYC or S6kIIK231R.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4hs.2sev.
Expression of either cdi33-077, cdi34-165 or cdi44-004 under the control of Scer\GAL4hs.2sev suppresses the rough eye phenotype of sevS11.T:Hsap\MYC flies. In the absence of the Scer\GAL4hs.2sev driver, no suppression is seen.
Expression of either cdi34-165y- or cdi44-004y- under the control of Scer\GAL4hs.2sev suppresses the rough eye phenotype of sevS11.T:Hsap\MYC flies.
Expression of cdi33-077y- under the control of Scer\GAL4hs.2sev does not suppress the rough eye phenotype of sevS11.T:Hsap\MYC flies.
Expression of cdiScer\UAS.cSa under the control of Scer\GAL4hs.2sev partially suppresses the extra R7 photoreceptor cell phenotype of sevS11.T:Hsap\MYC flies.
Expression of mRpL55Scer\UAS.cSa under the control of Scer\GAL4hs.2sev does not suppress the eye phenotype of sevS11.T:Hsap\MYC flies.
Expression of sshdsRNA.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4hs.2sev partially suppresses the extra R7 photoreceptor cell phenotype of sevS11.T:Hsap\MYC flies.
tsr2/tsrntf weakly suppresses the extra R7 photoreceptor cell phenotype of sevS11.T:Hsap\MYC flies.
Co-expression of Mkp3hs.sev almost completely suppresses the extra R7 photoreceptor cell phenotype seen in flies expressing sevS11.T:Hsap\MYC.
The addition of dosR31 almost completely suppresses the rough eye phenotype seen in sevS11.T:Hsap\MYC animals. The addition of both dosR31 and doshs.2sev does not suppress the phenotype. The addition of both dosR31 and dosR644K.R696K.hs.2sev or dosR696K.hs.2sev continues to suppress the rough eye phenotype. The addition of both dosR644K.hs.2sev partially suppresses the rough eye phenotype.
mask10.22 dominantly suppresses the ectopic R7 phenotype caused by sevS11.T:Hsap\MYC; the double mutant flies have an average of 1.8 ectopic R7 cells per ommatidium. mask5.8 dominantly suppresses the ectopic R7 phenotype caused by sevS11.T:Hsap\MYC; the double mutant flies have an average of 1.9 ectopic R7 cells per ommatidium.
When SelDk11320 is added to sevS11.T:Hsap\MYC flies, there is an increase of wild-type ommatidia from less than 10% to more than 50%. Only 7.5% of ommatidia in sevS11.T:Hsap\MYC eyes contain one R7 cell, the addition of SelDk11320 increases that to 61.2%. The addition of Catn1 also suppresses these phenotypes.
The addition of heterozygous dosR31 or dosP115 largely suppresses the sevS11.T:Hsap\MYC rough eye phenotype. The addition of doshs.T:Avic\GFP to dosR31/sevS11.T:Hsap\MYC flies restores the multiple R7 phenotype.
The extra R7 photoreceptor cells seen in flies carrying sevS11.T:Hsap\MYC are reduced to an average of 2.71 +/- 0.23 or 2.32 +/- 0.11 R7 photoreceptor cells per ommatidium if the flies are also carrying rin1 or rin2 respectively.
Expression of CblDv.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF in combination with sevS11.T:Hsap\MYC at 29[o]C produces melanotic tumours in the eyes in approximately 40% of progeny.
vapScer\UAS.T:Hsap\MYC does not suppress the sevS11.T:Hsap\MYC phenotype when expressed under the control of Scer\GAL4hs.2sev.
The sevS11.T:Hsap\MYC rough eye phenotype is dominantly suppressed by Nrtunspecified or DabS119A.hs.2sev and is enhanced by DabΔPro.hs.2sev.
Ras85DV12.sev in combination with sevS11.T:Hsap\MYC results in synthetic lethality. Expression of sevS11.T:Hsap\MYC above a certain level in embryos results in lethality and this lethality is enhanced by co-expression of Ras85DV12.sev. The lethality is sensitive to the expression levels of both sevS11.T:Hsap\MYC and Ras85DV12.sev. Less than 10% of sevS11.T:Hsap\MYC Ras85DV12.sev embryos form cuticle. Those embryos that do form cuticle generally have missing or malformed anterior structures including head parts and thoracic segments, as marked by absence of denticle belts. Approximately one-third of the embryos show curling of the cuticle, possibly due to a failure in germband retraction, and approximately one-tenth of embryos have a weak dorsal closure phenotype. A small fraction of embryos have missing or fused abdominal denticle belts, swollen anterior segments or completely lack identifiable structures and form a ball of cuticle. sevS11.T:Hsap\MYC embryos show a similar range of phenotypes. sevS11.T:Hsap\MYC is not lethal in combination with phylsev.PC, rosev.PI, aopACT.sev, phylhs.sev or Ras85DN17.hs.2sev. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Trl62, trxunspecified, Df(2L)JK12, skd2, osa2, mor1, kto1, kis1, kis2, brm1, brm2, Df(3R)red-P52, RpII140AS, RpII15V, SR3-8XS-701, SR3-8S-959, SR3-7XS-17N, SR3-7S-499, Taf1XS-2232, Taf1S-625, Su(Tpl)S-705, Su(Tpl)S-192, Taf4S-466, Taf4XS-793, Taf6XS-922, Sose4G, Ras85De1B, Ras85DE4, rlXS-2275, rlXS-2442, ksrXS-2424, ksrXS-2832, phyl2829, phyl2245, βggt-IS-2554, mamS-176, Df(3R)293γ5, Df(2L)ast2, Df(2R)nap9, Df(2R)pk78c or Df(3L)vin2. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by l(3)0624006240, l(3)0626506265, l(3)0929109291, Rpd304556, l(3)0514305143, btl00208, btl04727, frc10098, ftz-f103649, eRF105637, l(3)77CDf04521, tws02414, tws06848, l(3)0360803608, l(3)0665806658, osa04539, fray07551, l(3)0582005820, InR05545, pnt04263b, pnt07825, l(3)0307703077, l(3)0470804708, l(3)0674306743 or l(3)0673406734. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by the l(3)06948 line (l(3)06948a06948a and sr06948b), by the l(3)03745 line (tws03745a and Dl03745b) and by the l(3)04704 line (l(3)04704a04704a and l(3)04704b04704b). The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by TfIIA-SE32, ash12, Vha5515, Vha5516, mor2, osa1, sls1, skd1, Df(3R)urd, urd2, vtd3, Pc3 or Pc4.
TfIIA-SE73 suppresses the rough eye phenotype of sevS11.T:Hsap\MYC, phl::tor12D.hs.sev, Ras85DV12.sev, rlSem and svp2.sev.
Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.
The number of ectopic R7 cells is highly sensitive to the wild-type genetic background.
Constitutively activated sev kinase.
Ligand independent allele.