FB2025_01 , released February 20, 2025
Allele: Dmel\RpS2P
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General Information
Symbol
Dmel\RpS2P
Species
D. melanogaster
Name
FlyBase ID
FBal0032757
Feature type
allele
Associated gene
Dmel\RpS2
Associated Insertion(s)
P{A92}RpS2P
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Cramton and Laski, 1994)
Mutagen
Delta2-3 transposase
(Cramton and Laski, 1994)
Progenitor genotype
Associated Insertion(s)
P{A92}RpS2P
Cytology
Description

P{A92} insertion is located 28 nucleotides upstream of the 5' end of the cDNA.

(Cramton and Laski, 1994)
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RpS2P/RpS2P mutants are viable and cause female sterility. RpS2P/RpS2P and RpS2P/RpS2PRW1 ovaries exhibit a "string of pearls" phenotype wherein all egg chambers arrest development at stages two or three, and also exhibit abnormalities in germline stem cell divisions, abnormal spectrosomes, and delayed egg chamber growth.

      (Minakhina et al., 2016)

      Semi-lethal. The survival rate of sopP homozygotes is 10-15% of normal. Homozygotes eclose at least 2 days later than their wild type sibs. Egg chambers in homozygous mutant ovaries appear to develop normally until approximately stage 5, but development does not continue beyond this point. Homozygotes also show a mutant bristle phenotype. Macrochaetae on the thorax and head are shorter and thinner and more brittle than those of heterozygous siblings or wild type flies.

      (Cramton and Laski, 1994)

      Homozygous females arrest oogenesis at stage 5. Bristle phenotype in males and females.

      (Cramton et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      RpS2P/RpS2PRW1 has ovary | adult stage phenotype, enhanceable by Zfrp8[+]/Zfrp8SM206

      (Minakhina et al., 2016)
      Enhancer of
      Statement
      Reference

      RpS2[+]/RpS2P is an enhancer of ovary | adult stage phenotype of Scer\GAL4nanos.PU, Zfrp8GL00541

      (Minakhina et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Zfrp8SM206/+ enhances the ovary phenotypes of RpS2P/RpS2PRW1 mutants.

      RpS2P/+ enhances the ovary defects of flies expressing Zfrp8GL00541 under the control of Scer\GAL4nos.PU.

      (Minakhina et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Δ2-3 revertants have lost the P{A92} insertion.

      (Cramton and Laski, 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RpS2P
      (Minakhina et al., 2016)
      sop1
      sopP
      (Jagut et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)