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General Information
Symbol
Dmel\svp1.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0032835
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

svp type 1 cDNA expressed from a sev enhancer/promoter cassette.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

One copy causes mild external eye roughening, two copies enhances the roughening. Dosage-dependent (two or more copies of P{sev-svp1}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. Also an increasing number of ommatidia have malformed and collapsed lenses.

Rough eye phenotype. Transformation of cone cells towards R7 neurons. Increased copies of P{sev-svp1} cause ommatidia to contain seven or more outer photoreceptors and one or more R7 cells, this represents a transformation of R7 to an outer photoreceptor.

Eye roughening, due to cone cells being transformed into extra photoreceptor R7-like cells. Extra cells are recruited to become cone cells: there is no depletion of cone cell numbers. sina, but neither sev nor boss, is required for this cone cell transformation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement
Reference

svp1.sev has phenotype, enhanceable by RasGAP1rI533/Gap1rI533

svp1.sev has phenotype, enhanceable by Ras85DV12.sev

svp1.sev has phenotype, enhanceable by SosJC2

svp1.sev has phenotype, enhanceable by aopA141

svp1.sev has phenotype, enhanceable by aopyan-1

svp1.sev has phenotype, enhanceable by Raf::tor12D.hs.sev

svp1.sev has phenotype, enhanceable by rlSem

svp1.sev has phenotype, enhanceable by sevS11.Tag:MYC

Suppressed by
Statement
Reference

svp1.sev has phenotype, suppressible by Egfrf11

svp1.sev has phenotype, suppressible by Egfrt1

svp1.sev has phenotype, suppressible by rl10

svp1.sev has phenotype, suppressible by rl10a

svp1.sev has phenotype, suppressible by Ras85De2F

svp1.sev has phenotype, suppressible by Sose4G

svp1.sev has phenotype, suppressible by drkE(sev)2B/drke0A

svp1.sev has phenotype, suppressible by Raf1

svp1.sev has phenotype, suppressible by Raf7

svp1.sev has phenotype, suppressible by phylodin17L1

svp1.sev has phenotype, suppressible by phylodin3G6

svp1.sev has phenotype, suppressible by Dsor1LF133

svp1.sev has phenotype, suppressible by EgfrA3

svp1.sev has phenotype, suppressible by EgfrB24

svp1.sev has phenotype, suppressible by Ras85DC33

svp1.sev has phenotype, suppressible by SosF1

svp1.sev has phenotype, suppressible by RafLQ129

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Effect is weaker than for svp2.sev. Phenotype depends on C terminal portion of the protein, see svpsev.ΔMlu, svpsev.ΔSal and svpsev.ΔSal.

Cone cell transformation can be dominantly suppressed by mutations in components of the Ras85D signal transduction cascade. Mutations in negative regulators of Ras85D activity act as dominant enhancers.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
svp1.sev
Name Synonyms
Secondary FlyBase IDs
    References (5)