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General Information
Symbol
Dmel\svp2.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0032837
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sev-svp
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

svp type 2 cDNA expressed from a sev enhancer/promoter cassette.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Extra inner R7 photoreceptors in many ommatidia.

One copy causes mild external eye roughening, two copies enhance the roughening. Dosage-dependent (two or more copies of P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors. Also an increasing number of ommatidia have malformed and collapsed lenses.

Rough eye phenotype. Transformation of cone cells towards R7 neurons. Increased copies of P{sev-svp1} cause ommatidia to contain seven or more outer photoreceptors and one or more R7 cells, this represents a transformation of R7 to an outer photoreceptor.

Transformation of cone cells and photoreceptor cell 7 to photoreceptor cell 7 or outer photoreceptors.

Eye roughening, due to cone cells being transformed into extra photoreceptor R7-like cells. Extra cells are recruited to become cone cells: there is no depletion of cone cell numbers. sina, but neither sev nor boss, is required for this cone cell transformation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

svp2.sev has visible phenotype, enhanceable by mblA.sev

Suppressed by
Statement
Reference

svp2.sev has visible phenotype, suppressible by rin1/rin[+]

svp2.sev has visible phenotype, suppressible by mblk05507b

svp2.sev has visible phenotype, suppressible by mblE27

Phenotype Manifest In
Enhanced by
Statement
Reference

svp2.sev has phenotype, enhanceable by mblB.sev

svp2.sev has phenotype, enhanceable by sevS11.Tag:MYC

svp2.sev has phenotype, enhanceable by RasGAP1rI533/Gap1rI533

svp2.sev has phenotype, enhanceable by Ras85DV12.sev

svp2.sev has phenotype, enhanceable by SosJC2

svp2.sev has phenotype, enhanceable by aopA141

svp2.sev has phenotype, enhanceable by aopyan-1

svp2.sev has phenotype, enhanceable by Raf::tor12D.hs.sev

svp2.sev has phenotype, enhanceable by rlSem

Suppressed by
Statement
Reference

svp2.sev has eye phenotype, suppressible by rin1/rin[+]

svp2.sev has eye phenotype, suppressible by TfIIA-SE73

svp2.sev has phenotype, suppressible by Egfrf11

svp2.sev has phenotype, suppressible by Egfrt1

svp2.sev has phenotype, suppressible by drkE(sev)2B/drke0A

svp2.sev has phenotype, suppressible by Raf1

svp2.sev has phenotype, suppressible by Raf7

svp2.sev has phenotype, suppressible by phylodin17L1

svp2.sev has phenotype, suppressible by phylodin3G6

svp2.sev has phenotype, suppressible by rl10

svp2.sev has phenotype, suppressible by rl10a

svp2.sev has phenotype, suppressible by EgfrF15

svp2.sev has phenotype, suppressible by Egfrf3

svp2.sev has phenotype, suppressible by Ras85DC33

svp2.sev has phenotype, suppressible by SosF1

svp2.sev has phenotype, suppressible by Sose4G

svp2.sev has phenotype, suppressible by drke0A/drke0A

svp2.sev has phenotype, suppressible by RafLQ129

svp2.sev has phenotype, suppressible by rl15M1

svp2.sev has phenotype, suppressible by EgfrA3

svp2.sev has phenotype, suppressible by EgfrB24

svp2.sev has phenotype, suppressible by Df(2R)17

svp2.sev has phenotype, suppressible by Df(2R)27

svp2.sev has phenotype, suppressible by psqD91

svp2.sev has phenotype, suppressible by psqE39

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Phenotype can be suppressed by mblk05507b and mblE27, most ommatidia have a wild-type appearance. Phenotype can be enhanced by mblA.sev, many ommatidia contain extra photoreceptors of the outer type, up to 11 outer photoreceptors instead of the normal 6.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Phenotype depends on C terminal portion of the protein, see svpsev.ΔMlu, svpsev.ΔSal and svpsev.ΔSal.

Cone cell transformation can be dominantly suppressed by mutations in components of the Ras85D signal transduction cascade. Mutations in negative regulators of Ras85D activity act as dominant enhancers.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
svp2.sev
Name Synonyms
Secondary FlyBase IDs
    References (10)