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General Information
Symbol
Dmel\rhoPΔ38
Species
D. melanogaster
Name
FlyBase ID
FBal0033086
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rhoΔ38, rho38, rhoP38
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Deletion removing whole of P{lwB}X81 and extending to between 88 nucleotides 3' of the presumed initiating ATG and 267 nucleotides 3' to this ATG.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

rhoPΔ38 mutant clones generated in third instar larval eye discs occasionally show some morphological defects in the visual system, although lamina cartridge neuron differentiation appears unaffected. The 'on/off transients" (representing the activity of post-synaptic lamina cartridge neurons) that are normally seen in wild type are still present.

The overall morphology of lch5 chordotonal organs is disrupted in rhoPΔ38 mutant embryos. In addition, these organs have only 1 cap attachement cell rather than the 2 per organ seen in wild-type, while lch5 ligament attachment cells are often absent or deformed.

Homozygous embryos show loss of VA2 muscle precursor cells (only 2.3% of hemisegments contain VA2 precursor cells).

The number of midline glia cells surviving to stage 16 is decreased to an average of 0.9 +/- 0.1 cells per segment in homozygous embryos.

Mutant embryos exhibit tracheal phenotype.

In stage 12/3 homozygous embryos the commissures are thicker and narrower than wild type and by stage 14 they remain incompletely separated. In stage 12/5 embryos the wild type number of midline glia are present but appear tightly clustered and displayed dorsally. Reduction in cell number from stage 13 until 14. Reduction in the VUM cell number at stage 11, during stage 13 half the wild type number of neurons migrate ventrally, these are still present at stage 14. All MP1 neurons are present at stage 13 but are disconnected from each other, by stage 14 this separation has grown. In stage 14 embryos there is a reduced number of en+ neurons present at the midline.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
NOT Enhancer of
Statement
Reference
NOT Suppressor of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Expression of csw::Src64Bsrc90.Scer\UAS under the control of Scer\GAL4twi.PG significantly suppresses the loss of VA2 muscle precursor cells seen in rhoPΔ38 embryos (69% of hemisegments have VA2 cells).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Partially rescued by

rhoPΔ38 is partially rescued by rhohs.PSt

Comments

The addition of rhoScer\UAS.cXa driven by Scer\GAL4sim.P3.7 to rhoPΔ38 embryos is not sufficient to rescue the loss of midline glial cell phenotype seen in these mutants. The ubiquitous expression of rhohs.PSt under heatshock is sufficient to suppress the loss of midline glial cell seen in rhoPΔ38 embryos to wild-type.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Fails to complement rho7M43.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (9)
References (22)