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General Information
Symbol
Dmel\wBR.BR
Species
D. melanogaster
Name
FlyBase ID
FBal0033129
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

w+mC minigene, which contains approximately 300bp of 5' flanking and 630bp of 3' flanking DNA, is flanked by two 430bp of su(Hw) binding region (gypsy sequences between nucleotides 647 and 1077).

Construct: w+mC minigene altered to include the su(Hw) binding region (all 12 binding sites, nucleotides 647 to 1077 of Marlor et al., Mol Cell Biol 6:1129-1134 ) upstream of the w coding region, upstream of a second su(Hw) binding region.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eye color: yellow

The wBR.BR mutation in X insertion lines shows complete dosage compensation. All autosomal insertion lines show some degree of dosage compensation, results suggest that the mini-w gene surrounded by su(Hw) binding region has an enhanced ability to dosage compensate at autosomal locations. In a su(Hw)- mutant background compensation of autosomal insertion lines is incomplete, dosage compensation on the X chromosome is largely unaffected. Lack of hypercompensation of X insertion lines may be consequence of the sequences into which the insertion was integrated.

Eye colour: yellow, in the majority of flies; indistinguishable from that of wE.BR.BR.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
NOT Enhanced by
NOT suppressed by
Statement
Reference
Phenotype Manifest In
Enhanced by
NOT Enhanced by
NOT suppressed by
Statement
Reference

wBR.BR has pigment cell phenotype, non-suppressible by ScmZnF.hs.Tag:FLAG

wBR.BR has pigment cell phenotype, non-suppressible by escZnF.hs.Tag:FLAG

Additional Comments
Genetic Interactions
Statement
Reference

Expression of wBR.BR is reduced (in a background of reduced su(Hw)+) by the expression of tethered Pc, Scm or esc. In the case of Pchs.T:su(Hw)-ZnF,T:Zzzz\FLAG, the effect is seen without the use of heat shock. For Scmhs.T:su(Hw)-ZnF,T:Zzzz\FLAG and eschs.T:su(Hw)-ZnF,T:Zzzz\FLAG heat shock must be applied daily. In the case of eschs.T:su(Hw)-ZnF,T:Zzzz\FLAG the effect is dependent on the site of insertion of P{SUPor-P-lt}, in that is seen for P{SUPor-P-lt}43B but not for P{SUPor-P-lt}28C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
wBR.BR
Name Synonyms
Secondary FlyBase IDs
    References (6)