FB2025_01 , released February 20, 2025
Allele: Dmel\wblT6
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General Information
Symbol
Dmel\wblT6
Species
D. melanogaster
Name
FlyBase ID
FBal0033173
Feature type
allele
Associated gene
Dmel\wbl
Associated Insertion(s)
Carried in Construct
Also Known As
windT6
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Konsolaki and Schupbach, 1998)
Progenitor genotype
Cytology
Description

Amino acid replacement: L239P.

(Konsolaki and Schupbach, 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,250,744..19,250,744 [+]
Nucleotide change:

T19250744C

Amino acid change:

L239P | wbl-PA; L239P | wbl-PB

Reported amino acid change:

L239P

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Konsolaki and Schupbach, 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      wblRP/wblT6 flies are smaller than wblT6/+ flies.

      (Zhu et al., 2005)

      Embryos derived from homozygous females are strongly dorsalised. Homozygous adults show reduced viability, the lethal phase being between the second and third larval instar stages. Transheterozygotes with wblRP, wblM88, wblM46, wblE4 or wblAR51 also have reduced viability, and embryos derived from these transheterozygous females are dorsalised and fail to hatch.

      (Konsolaki and Schupbach, 1998)

      Embryos transplanted with perivitelline fluid from Tl2 embryos exhibit a polar gastrulation. At the end of embryogenesis an almost complete restoration of pattern along the dorsoventral axis is seen. The point of injection determines the ventralmost point of the restored pattern.

      (Stein et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      When piphs.PS is uniformly expressed in wblT6/wblRP females, the resulting embryos are dorsalised.

      (Sen et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      wblT6
      windT6
      (Zhu et al., 2005, Sen et al., 2000, Sen et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)