Allele Dmel\Abd-B^M3

General Information
Symbol	Dmel\Abd-B^M3	Species	D. melanogaster
Name		FlyBase ID	FBal0033316
Feature type	allele	Associated gene	Dmel\Abd-B

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (de Lorenzi and Bienz, 1990, Celniker et al., 1990)
Mutagen	ethyl methanesulfonate (Sanchez-Herrero et al., 1985, de Lorenzi and Bienz, 1990, Kuhn et al., 1992, Kuhn et al., 1993)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutations within coding region: eliminate m function. (de Lorenzi and Bienz, 1990)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Kuhn et al., 1993) visible \| homeotic (Sanchez-Herrero and Crosby, 1988)
Phenotype Manifest In
	abdominal segment 5 (Sanchez-Herrero and Crosby, 1988) abdominal segment 6 (Sanchez-Herrero and Crosby, 1988) abdominal segment 7 (Sanchez-Herrero and Crosby, 1988) abdominal segment 8 (Sanchez-Herrero and Crosby, 1988) abdominal tergite 8 \| somatic clone (Foronda et al., 2006) adult head (Kuhn et al., 1993) embryonic/larval posterior spiracle \| embryonic stage (Kuhn et al., 1995) female analia (Kuhn et al., 1995) female genitalia (Kuhn et al., 1995) genitalia \| female (Sanchez-Herrero and Crosby, 1988) parasegment 10 (Sanchez-Herrero and Crosby, 1988) parasegment 11 (Sanchez-Herrero and Crosby, 1988) parasegment 12 (Sanchez-Herrero and Crosby, 1988) parasegment 13 (Sanchez-Herrero and Crosby, 1988)
Detailed Description
	Statement Reference Abd-B^M3 male mutant clones exhibit transformation of the tiny A8 segment into an anterior abdominal segment. (Foronda et al., 2006) Adult females have eight abdominal segments, lack genitalia and (occasionally) analia. Males have eight abdominal segments and retain both genitalia and analia. In these flies parasegment 13 is transformed towards 10 while parasegment 14 is unaffected. Embryos lack posterior spiracles. (Kuhn et al., 1995) Reduced penetrance of head defect phenotype when in trans with Abd-B^iab9-tuh-3. (Kuhn et al., 1993) A5-A8 are transformed to A4, females lack genitalia, and there is a weak haploinsufficient transformation of A5-A8. Parasegments 10-13 are transformed to parasegment 9 in embryos. (Sanchez-Herrero and Crosby, 1988)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	Abd-B^iab8-rv96 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv100 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv107 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv111 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv114 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv175 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv185 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-Tab (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-tuh-3 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-x23-1 (Sanchez-Herrero and Crosby, 1988) Abd-B^Uab-1 (Sanchez-Herrero and Crosby, 1988)
Partially complements	Abd-B^iab9-tuh-3 (Kuhn et al., 1993)
Fails to complement	Abd-B²⁹⁷ (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-D3 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-D16 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv5 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv10 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab8-rv75 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-48 (Sanchez-Herrero and Crosby, 1988) Abd-B^iab9-65 (Sanchez-Herrero and Crosby, 1988) Abd-B^M1 (Sanchez-Herrero and Crosby, 1988) Abd-B^M8 (Sanchez-Herrero and Crosby, 1988) Abd-B^S4 (Sanchez-Herrero and Crosby, 1988) Abd-B^S7 (Sanchez-Herrero and Crosby, 1988) Abd-B^S11 (Sanchez-Herrero and Crosby, 1988)
Comments	Fails to complement iab-5 and iab-6 alleles. (Sanchez-Herrero and Crosby, 1988)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Abd-B m^-r⁺ mutation. (Kuhn et al., 1995) m^- r⁺ mutant, eliminating function of Abd-B function. (Kuhn et al., 1993) Mutant in m function. This allele originally described in Sanchez-Herrero et al, Nature 313: 108--113. (Kuhn et al., 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Abd-B^m3 (de Lorenzi and Bienz, 1990) Abd-B^M3
Name Synonym
Secondary FlyBase IDs

References ( 9 )
Research paper	Foronda et al., 2006, Development 133(1): 117--127 Requirement of abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. [FBrf0190286] Estrada et al., 2002, Development 129(22): 5195--5204 Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila melanogaster. [FBrf0151935] Kuhn et al., 1995, Mech. Dev. 53(1): 3--13 Analysis of the genes involved in organizing the tail segments of the Drosophila melanogaster embryo. [FBrf0084100] Kuhn et al., 1993, Genetics 133(3): 593--604 Tumorous-head (tuh-1; tuh-3) modulates Abd-B Bithorax-complex functions in Drosophila melanogaster. [FBrf0058571] Kuhn et al., 1992, Development 116(1): 11--20 Development of the Drosophila melanogaster caudal segments involves suppression of the ventral regions of A8, A9 and A10. [FBrf0055839] Celniker et al., 1990, EMBO J. 9(13): 4277--4286 The molecular genetics of the Bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. [FBrf0051665] de Lorenzi and Bienz, 1990, Development 108: 323--329 Expression of Abdominal-B homeoproteins in Drosophila embryos. [FBrf0051569] Sanchez-Herrero and Crosby, 1988, EMBO J. 7(7): 2163--2173 The Abdominal-B gene of Drosophila melanogaster: overlapping transcripts exhibit two different spatial distributions. [FBrf0047933] Sanchez-Herrero et al., 1985, Nature 313: 108--113 Genetic organization of Drosophila Bithorax complex. [FBrf0043314]

Allele Dmel\Abd-BM3

Allele Dmel\Abd-B^M3