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General Information
Symbol
Dmel\Ca-α1DX10
Species
D. melanogaster
Name
FlyBase ID
FBal0033485
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dmca1DX10
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:
C16183977T
Amino acid change:
R1800term | Ca-alpha1D-PA; R1803term | Ca-alpha1D-PB; R1836term | Ca-alpha1D-PC; R1800term | Ca-alpha1D-PD; R1830term | Ca-alpha1D-PE; R1307term | Ca-alpha1D-PF; R1307term | Ca-alpha1D-PG; R1307term | Ca-alpha1D-PH; R1310term | Ca-alpha1D-PI; R1343term | Ca-alpha1D-PJ
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Mutation of a TaqI site from TCGA to TTGA, thereby changing an Arg codon to a stop codon. Residue resides in the cytoplasmic loop just following the IV-S4 transmembrane domain, producing a truncated protein missing the last two transmembrane domains (IV-S5 and IV-S6) and cytoplasmic carboxy tail.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Mutants die at the late embryonic stage with no gross morphological abnormalities. The tracheae of mutant embryos generally do not become gas-filled. Embryos do move but the movements are very weak: slow localised twitches, usually at the posterior end. Some peristaltic motion is visible in the gut, this is very slow. Occasionally embryos bend their heads but movement of the cephalopharyngeal apparatus is not seen. Pumping of the heart is not seen.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference
Ca-α1DX10 cac20-3/Df(1)RC29 double mutant embryos show no defect in the number of varicosities or innervation pattern at the neuromuscular junction of muscle fibres 6 and 7.
Xenogenetic Interactions
Statement
Reference
Ca-α1DX10/+ reverses the increase in resting synaptic Ca[2+] levels at presynaptic terminals seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4elav-C155 larvae. Ca-α1DX10/+ significantly suppresses the increased excitatory junction potential (EJP) amplitude and decreased failure rate seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4elav-C155 animals at 0.25 mM Ca[2+]. Ca-α1DX10/+ suppresses the reduced number of rhabdomeres per ommatidium phenotype seen in Hsap\HD128Q.FL.Scer\UAS, Scer\GAL4GMR.PF animals at 20 days.
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
S. Roth.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (9)