Allele Dmel\srpk79D^P1

General Information
Symbol	Dmel\srpk79D^P1	Species	D. melanogaster
Name		FlyBase ID	FBal0033567
Feature type	allele	Associated gene	Dmel\srpk79D
Also Known As	csp^P2

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (Zinsmaier et al., 1994)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3L:22,268,457..22,268,457 (Eberle et al., 1998, Nieratschker et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The P{lacW}srpk79D[P1] transposon is inserted 81 bp upstream of the first exon-intron boundary of the srpk79D RC/RF transcript and destroys the open reading frame of these mRNAs. (Nieratschker et al., 2009) Insertion of a P{lacW} element downstream of the Csp transcription start site. The 3' end of the P{lacW} element is closest to the Csp transcription unit. (Eberle et al., 1998) P-element insertion at map position +7.8. (Zinsmaier et al., 1994)
Caused by insertion	P{lacW}srpk79D^P1 (Eberle et al., 1998, Nieratschker et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	flight defective \| recessive (Nieratschker et al., 2009) locomotor behavior defective \| recessive (Nieratschker et al., 2009) short lived \| recessive (Nieratschker et al., 2009)
Phenotype Manifest In

Detailed Description
	Statement Reference General axonal transport and basic synaptic structure appear intact in srpk79D[P1] mutants. srpk79D[P1] mutant flies display flight impairment, reduced ability or motivation to walk on a horizontal surface, as well as reduced life span. (Nieratschker et al., 2009) Shows no reconizable mutant phenotype. (Eberle et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	srpk79D^P1 is partially rescued by srpk79D^{RF.Scer\UAS.cNa} (Nieratschker et al., 2009)
Comments	The impaired flight, impaired walking and reduced longevity of srpk79D[P1] mutants are fully or partially rescued by transgenic pan-neural expression of srpk79D[RF.Scer\UAS.cNa] driven by Scer\GAL4[elav-C155]. (Nieratschker et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Expression pattern of Csp is apparently normal. (Eberle et al., 1998)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	csp^P2 (Eberle et al., 1998, Zinsmaier et al., 1994) Csp^P2 srpk79D^P1 Srpk79D^P1 (Nieratschker et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Nieratschker et al., 2009, PLoS Genet. 5(10): e1000700 Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila. [FBrf0208928] Eberle et al., 1998, Cell Tissue Res. 294(2): 203--217 Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis. [FBrf0104892] Zinsmaier et al., 1994, Science 263(5149): 977--980 Paralysis and early death in cysteine string protein mutants of Drosophila. [FBrf0068753]

Allele Dmel\srpk79DP1

Allele Dmel\srpk79D^P1