|Feature type||allele||Associated gene||Dmel\Egfr|
|Also Known As||topEC20, derEC20|
|Map ( GBrowse )|
|Allele class||loss of function allele|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Nucleotide substitution: G1513A. Amino acid replacement: D382N.
|Phenotype Manifest In|
Enhances the female sterility and adult morphological defects of Egfrt1. Rarely survives as transheterozygote with the semi-viable Egfrtop-CA allele.
Does not suppress the "Ellipse" phenotype. Hemizygotes die during pupariation, and have abnormally small dorsal imaginal discs.
Homozygous embryos show no defects, hemizygotes are pupal lethal. When in combination with Df(2R)Egfr3 the eye-antennal, wing and haltere imaginal discs give rise to eyes, wings and halteres that are reduced size due to altered development of the imaginal disc. Embryos produced from heteroallelic combination with Egfrt1 have a severe ventralised phenotype, reduction in size of their dorsal appendage.
|Phenotype Manifest In|
|NOT Enhancer of|
Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4en-e16E in a Egfrtop-EC20/+ background results in ectopic wing vein material in 86% of flies and occasional thinning of a section of the L4 longitudinal wing vein. The anterior crossvein loss phenotype of Socs36EScer\UAS.P\T.cCa-expressing flies is not affected.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Class I allele.
Mutation of Egfr that coordinately affects all gene activities, a class I lesion. The allelic series for class I lesions: Egfrt2 = Egfrt1 < Egfrtop-EC20 < Egfrf7 = Egfrf1 = Egfrflb-2E07 < Egfrtop-EE39 = Egfrtop-ED26 = Egfrf5 < Egfrf9 = Egfrf10 = Egfrf2 = Egfrtop-EE42 = Egfrf11 = Egfrf24 = Egfrf3 = Df(2R)Egfr3.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 6 )|