FlyBase Allele Report: Dmel\Khc[+t7.5]

General Information

Symbol

Dmel\Khc^+t7.5

Species

D. melanogaster

Name

FlyBase ID

FBal0033768

Feature type

allele

Associated gene

Dmel\Khc

Associated Insertion(s)

Carried in Construct

P{Khc7.5}

Key Links

Genomic Maps

JBrowse

Transgenic product class

genomic_DNA

(Saxton et al., 1991)

wild_type

(Saxton et al., 1991)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

genomic_DNA

(Saxton et al., 1991)

wild_type

(Saxton et al., 1991)

Mutagen

in vitro construct

(Saxton et al., 1991)

Progenitor genotype

Carried in construct

P{Khc7.5}

Cytology

Description

Contained within a 7.5kb genomic EcoRI-BamHI fragment including the Khc 3.5kb transcription unit and 4kb of non-coding DNA.

(Saxton et al., 1991)

Allele components

Component

Use(s)

Regulatory region(s)

Khc

Encoded product / tool

Khc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

rescue_region

2R:16,266,453..16,274,261 [-]

Linked to:

BamHI-EcoRI restriction fragment

Comment:

Position of restriction fragment on reference sequence inferred by FlyBase curator.

(Saxton et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cBa

(Tziortzouda et al., 2024)

modeled by Hsap\FUS^{R521G.UAS.cBa}

(Tziortzouda et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

wild-type

(Brendza et al., 2000, Brendza et al., 2000, Torroja et al., 1999, Hurd and Saxton, 1996, Hurd et al., 1996, Saxton et al., 1991)

Phenotype Manifest In

Detailed Description

Statement

Reference

Oocytes in females carrying Khc^+t7.5 do not show premature cytoplasmic streaming.

(Krauss et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Khc^+t7.5 rescues Khc²⁷

(Cha et al., 2002)

Khc^+t7.5 rescues Khc^5.287

(Januschke et al., 2002)

Khc^+t7.5 rescues Khc^7.288

(Januschke et al., 2002)

Khc^+t7.5 rescues Khc^8.70

(Januschke et al., 2002)

Khc^+t7.5 rescues Khc²⁰

(Brendza et al., 2000)

Khc^+t7.5 rescues Khc²⁷

(Brendza et al., 2000)

Khc^+t7.5 rescues Khc²⁷

(Brendza et al., 2000)

Khc^+t7.5 rescues Khc⁸

(Torroja et al., 1999)

Khc^+t7.5 rescues Khc⁶/Df(2R)Jp6

(Hurd and Saxton, 1996)

Khc^+t7.5 rescues Khc⁶/Khc^BD

(Hurd et al., 1996)

Khc^+t7.5 rescues Khc⁵/Khc⁴

(Hurd et al., 1996)

Khc^+t7.5 rescues Khc¹⁰

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc¹¹

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc¹²

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc¹³

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc²

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc³

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁷

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁹

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc^1ts

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁴

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁵

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁶

(Saxton et al., 1991)

Khc^+t7.5 rescues Khc⁸

(Saxton et al., 1991)

Comments

Khc^+t7.5 rescues posterior cortical localization of pole plasm markers in Khc²⁷ germ-line clone oocytes.

(Cha et al., 2002)

The terminal phenotype of Khc⁶/Df(2R)Jp6 wandering third instar larvae is completely rescued by a single copy of P{Khc7.5}.

(Hurd and Saxton, 1996)

Rescues the temperature sensitive paralysis of Khc⁴/Khc⁵ or Khc⁶/Khc^BD heteroallelic flies. Rescues the synthetic lethality of Khc mutant combinations with para or mle mutants. Relieves the leg shaking suppression of Sh¹⁴ and eag¹ mutants brought about by Khc⁶/Khc^BD.

(Hurd et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Khc^+t7.5

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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