|Name||heat shock construct of Lieber||FlyBase ID||FBal0033870|
|Feature type||allele||Associated gene||Dmel\N|
|Mutagen||in vitro construct - regulatory fusion, in vitro construct - deletion|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Heat-shocked N[Hsp70Bb.PL] flies show a greater than 4-fold increase in 1-day memory after single-cycle training.
The surface topology of cells expressing NHsp70Bb.PL is different from that of control cells.
Adult flies expressing NHsp70Bb.PL (using a 37oC heat shock) show normal reactivity to electric shock and normal olfactory acuity (to methylcyclohexanol and octanol). Flies in which NHsp70Bb.PL is expressed using a 30 minute heat shock show normal learning scores in a Pavlovian learning and memory assay, when trained and tested 3 hours after the heat shock. One day memory is also unaffected in these flies when they are subjected to the normal spaced training procedure (10 training cycles), however, flies that have only one or two spaced training sessions show enhanced one day memory compared to control flies.
Has no effect on the development of otherwise wild type embryos.
|NOT Suppressor of|
|Phenotype Manifest In|
The enhancement of long-term memory by N[Hsp70Bb.PL] over-expression is suppressed in klg[ruslan] or klg[GS10439]/klg[E226] flies.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
Stably expressed in S2 cells, and used in Notch signaling assays.
Carried in a plasmid and transfected into S2 cells to study the effect of the Dl and wg proteins on N protein.
Carried in a plasmid and transfected into S2 cells.
Carried in a plasmid, transfected into S2 cells and used in biochemical assays.
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 9 )|
heat shock construct of Lieber
|Secondary FlyBase IDs|
|References ( 11 )|