Allele Dmel\Ras85D^Sutor-341

General Information
Symbol	Dmel\Ras85D^Sutor-341	Species	D. melanogaster
Name		FlyBase ID	FBal0033980
Feature type	allele	Associated gene	Dmel\Ras85D

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Schnorr and Berg, 1996)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:5,337,467..5,337,467 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental na_change=A5337467T pr_change=R131@\|Ras85D-PA reported_pr_change=R131@ (Wu, 2000.1.28)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: R131@. The insertion of a new stop codon 3bp upstream of the second intron results in truncation of the protein, thereby eliminating the CAAX box. (Wu, 2000.1.28)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Doyle and Bishop, 1993) lethal \| recessive (Schnorr and Berg, 1996) viable \| partially (Schnorr and Berg, 1996) visible (Schnorr and Berg, 1996)
Phenotype Manifest In
	chorion (Schnorr and Berg, 1996) ommatidium (Schnorr and Berg, 1996)
Detailed Description
	Statement Reference Ras85D^Sutor-341/Ras85D⁰⁵⁷⁰³ transheterozygotes have low viability. Females transheterozygotes with Ras85D⁰⁵⁷⁰³ lay eggs with a severely disrupted eggshell (patch of chorion instead of dorsal appendages), 40% of eggs hatch and develop to normal larvae. Transheterozygotes with Ras85D⁰⁵⁷⁰³ exhibit slightly disrupted ommatidial array (small number of fused and misplaced ommatidia). (Schnorr and Berg, 1996)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Ras85D^Sutor-341/Ras85D[+] is a suppressor of visible phenotype of Egfr^E1 (Doyle and Bishop, 1993)
Phenotype Manifest In
Suppressor of
Statement Reference Ras85D^Sutor-341/Ras85D[+] is a suppressor of eye phenotype of Egfr^E1 (Doyle and Bishop, 1993) Ras85D^Sutor-341 is a suppressor of phenotype of tor^11D (Doyle and Bishop, 1993)
Additional Comments
Genetic Interactions
Statement Reference Weak suppression of the Egfr^E1 rough eye phenotype and strong suppression of tor^11D, embryos have 4 to 6 denticle belts. (Doyle and Bishop, 1993)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Maternal and zygotic activity. (Doyle and Bishop, 1993)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	341 (Li et al., 2000) Ras1^su(tor)341 (Schnorr and Berg, 1996) Ras85D^Sutor-341 Su(tor)3-2³⁴¹ (Doyle and Bishop, 1993)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Li et al., 2000, Genetics 156(2): 763--774 Identification of autosomal regions involved in Drosophila raf function. [FBrf0129944] Schnorr and Berg, 1996, Genetics 144(4): 1545--1557 Differential activity of Ras1 during patterning of the Drosophila dorsoventral axis. [FBrf0091163] Doyle and Bishop, 1993, Genes Dev. 7(4): 633--646 Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the Sevenless and EGF-R pathways in Drosophila. [FBrf0058535]
Personal communication to FlyBase	Wu, 2000.1.28, Molecular data. Molecular data. [FBrf0125107]

Allele Dmel\Ras85DSutor-341

Allele Dmel\Ras85D^Sutor-341