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General Information
Symbol
Dmel\Ras85DV12.sev
Species
D. melanogaster
Name
FlyBase ID
FBal0033983
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
sev-RasV12, sev-ras1v12, RasV12, Ras1V12, P[sev-RAS1V12], sevRasV12
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Construct: Ras85DV12 gene expression is driven by a sev promoter and one copy of the sev enhancer.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ras85DV12.sev flies have a rough eye phenotype.

Ras85DV12.sev flies display ommatidial fusion, producing a rough eye phenotype.

Flies carrying Ras85DV12.sev have a rough eye phenotype.

Ras85DV12.sev/+ mutants exhibit a mild rough eye phenotype.

Ras85DV12.sev flies have a rough eye phenotype.

Mutant animals have a rough eye phenotype.

Adults carrying Ras85DV12.sev have a rough eye phenotype.

Mutant animals exhibit a rough eye phenotype. Ommatidia have an average of 1.9 R7 cells compared to 1 per ommatidium in wild-type.

Flies expressing Ras85DV12.sev have extra R7 photoreceptors in the eye.

Flies carrying Ras85DV12.sev have a rough eye phenotype, with an average of 3.0 R7 cells per ommatidium.

Ras85DV12.sev flies have rough eyes.

Expression of Ras85DV12.sev results in extra photoreceptor R7 cells throughout the retina. Extra photoreceptor R7 cells are induced in the dorsal rim area (DRA) of the eye.

Expression of Ras85DV12.sev transforms cone cells in R7 neurons.

Flies carrying Ras85DV12.sev have a rough eye phenotype.

Ras85DV12.sev flies have a rough eye phenotype, and have an average of 3.1 R7 photoreceptor cells per ommatidium.

Expression of Ras85DV12.sev leads to the transformation of cone cells into R7 photoreceptors.

Flies carrying Ras85DV12.sev have supernumerary R7 cells and a rough eye phenotype.

Rough eye phenotype. 90% of ommatidia have supernumerary R7 cells.

Ras85DV12.sev flies do not exhibit melanotic tumours.

Flies carrying Ras85DV12.sev have a rough eye phenotype caused by excess R7 cells and destruction of the regular ommatidial array.

Transforms cone cells into R7 cells.

The Ras85DV12.sev phenotype is unaffected by halving the dose of sty+.

Expression causes a rough eye phenotype.

Eye surface is roughened.

Flies carrying Ras85DV12.sev have extra R7 photoreceptor cells.

Flies carrying Ras85DV12.sev have rough eyes, and some of the four cone cell precursors are transformed into extra R7 photoreceptor cells. Flies carrying two copies of Ras85DV12.sev have rougher eyes than flies carrying one copy of Ras85DV12.sev.

Rough eye phenotype associated with extra R7 photoreceptors and ommatidial fusions.

Homozygous 14-3-3ζE16 clones are not recovered in flies carrying Ras85DV12.sev.

Strong rough eye phenotype due to multiple R7 cells and induction of supernumerary cone cells.

Rough eye phenotype is not suppressed by mutations of Hsp83.

External roughening of the eye, three to four cone cells in each ommatidia are converted to R7 cells.

Ommatidia differentiate additional R7 cells.

Transforms nonneuronal cone cells into R7 photoreceptor cells, these extra R7 cells disrupt the normal packing of cells in ommatidia resulting in an external roughening of the eye.

Overexpression of argos (P{hs-argos.S}) or decrease in gene dosage (argos257) fail to affect the multiple R7 phenotype.

Flies with two copies of Ras85DV12.sev have a more extreme rough eye phenotype than flies with one copy.

Rough eye phenotype, more severe in flies bearing two copies. Cone cell precursors are transformed into supernumerary R7 cells. Only 2% of ommatidia in the center of the eye are wild type.

Rough eye phenotype is suppressed by JrabZIP.hs.sev.T:Ivir\HA1.

Rough eyes due to multiple R7 cells.

Homozygous drkE(sev)2B clones in P{sevRas1.V12} flies frequently develop as photoreceptors despite the lack of drk function. The rescued cells can be inner R1-R6-like photoreceptors or outer R7-like photoreceptors.

Rough eye phenotype, most ommatidia contain supernumerary R7 cells, aberrant packing and rotation of ommatidia, occasional extra or missing R1-R6 cells and missing pigment cells.

Rough eye phenotype, 75% ommatidia contain supernumerary R7-like cells, at the expense of cone cell precursors.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Ras85DV12.sev has visible phenotype, enhanceable by ed[+]/ed1X5

Ras85DV12.sev has visible phenotype, enhanceable by SM3-6SM3-6

Ras85DV12.sev has visible phenotype, enhanceable by SM3-8SM3-8

Ras85DV12.sev has visible phenotype, enhanceable by SK2-3unspecified/SK2-3[+]

Ras85DV12.sev has visible phenotype, enhanceable by pp2c99B[+]/alphS-292

Ras85DV12.sev has visible phenotype, enhanceable by pp2c99B[+]/alphS-331

Ras85DV12.sev has visible phenotype, enhanceable by alphS-355/pp2c99B[+]

Ras85DV12.sev has visible phenotype, enhanceable by pp2c99B[+]/alphXS-88

Ras85DV12.sev has visible phenotype, enhanceable by Src42Aunspecified/Src42A[+]

Ras85DV12.sev has visible phenotype, enhanceable by aopunspecified/aop[+]

Ras85DV12.sev has visible phenotype, enhanceable by Src42A15-1

Ras85DV12.sev has visible phenotype, enhanceable by Src42A18-2

Ras85DV12.sev has visible phenotype, enhanceable by Src42A7-4

Ras85DV12.sev has visible phenotype, enhanceable by Df(2R)nap8

Ras85DV12.sev has visible phenotype, enhanceable by Df(2R)nap9

Ras85DV12.sev has visible phenotype, enhanceable by Df(2R)nap1

Ras85DV12.sev has visible phenotype, enhanceable by In(2R)bwVDe2LCyR

NOT Enhanced by
Statement
Reference

Ras85DV12.sev has visible phenotype, non-enhanceable by simj[+]/simjunspecified

Ras85DV12.sev has visible phenotype, non-enhanceable by Egfr[+]/Egfrunspecified

Ras85DV12.sev has visible phenotype, non-enhanceable by Sunspecified/S[+]

Ras85DV12.sev has visible phenotype, non-enhanceable by Sosunspecified/Sos[+]

Ras85DV12.sev has visible phenotype, non-enhanceable by spenunspecified/spen[+]

Ras85DV12.sev has visible phenotype, non-enhanceable by Src42A1.15

Suppressed by
Statement
Reference

Ras85DV12.sev has visible phenotype, suppressible by rl[+]/rlS352

Ras85DV12.sev has visible phenotype, suppressible by CG748319/eIF4AIII[+]

Ras85DV12.sev has visible phenotype, suppressible by mago1/mago[+]

Ras85DV12.sev has visible phenotype, suppressible by mago[+]/mago2

Ras85DV12.sev has visible phenotype, suppressible by mago3/mago[+]

Ras85DV12.sev has visible phenotype, suppressible by tsu[+]/tsuEP567

Ras85DV12.sev has visible phenotype, suppressible by klu[+]/kluunspecified

Ras85DV12.sev has visible phenotype, suppressible | partially by Df(2R)PC4/+

Ras85DV12.sev has visible phenotype, suppressible | partially by edl[+]/edlk06602

Ras85DV12.sev has visible phenotype, suppressible | partially by mask10.22

Ras85DV12.sev has visible phenotype, suppressible by Taf6[+]/Taf6XS-922

Ras85DV12.sev has visible phenotype, suppressible by cswlf

Ras85DV12.sev has visible phenotype, suppressible by rin2/rin[+]

Ras85DV12.sev has visible phenotype, suppressible by rin1/rin[+]

Ras85DV12.sev has visible phenotype, suppressible by SEM2-4

Ras85DV12.sev has visible phenotype, suppressible by SEF2-1

Ras85DV12.sev has visible phenotype, suppressible by 14-3-3εunspecified/14-3-3epsilon[+]

Ras85DV12.sev has visible phenotype, suppressible by EK2-5[+]/EK2-5unspecified

Ras85DV12.sev has visible phenotype, suppressible by EK2-7[+]/EK2-7unspecified

Ras85DV12.sev has visible phenotype, suppressible by EK3-3unspecified/EK3-3[+]

Ras85DV12.sev has visible phenotype, suppressible by kisunspecified/kis[+]

Ras85DV12.sev has visible phenotype, suppressible by ksrunspecified/ksr[+]

Ras85DV12.sev has visible phenotype, suppressible by pntunspecified/pnt[+]

Ras85DV12.sev has visible phenotype, suppressible by rl[+]/rlunspecified

Ras85DV12.sev has visible phenotype, suppressible by Dsor1[+]/Dsor1unspecified

NOT suppressed by
Statement
Reference

Ras85DV12.sev has visible phenotype, non-suppressible by simj[+]/simjunspecified

Ras85DV12.sev has visible phenotype, non-suppressible by Egfr[+]/Egfrunspecified

Ras85DV12.sev has visible phenotype, non-suppressible by Sunspecified/S[+]

Ras85DV12.sev has visible phenotype, non-suppressible by Sosunspecified/Sos[+]

Ras85DV12.sev has visible phenotype, non-suppressible by spenunspecified/spen[+]

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by ash12

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Vha5515

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Vha5516

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by mor2

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by osa1

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by sls1

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by skd1

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by vtd3

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Pc3

Ras85DV12.sev, sevS11.Tag:MYC has lethal phenotype, non-suppressible by Pc4

Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Ras85DV12.sev is a suppressor | partially of visible phenotype of lzts1

NOT Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Ras85DV12.sev has eye phenotype, enhanceable by Ptp61F[+]/Ptp61F4-10

Ras85DV12.sev has eye phenotype, enhanceable by holn1c07150/CG5198[+]

Ras85DV12.sev has eye phenotype, enhanceable by alphS-355

Ras85DV12.sev has eye phenotype, enhanceable by Src42AS-527

Ras85DV12.sev has eye phenotype, enhanceable by Src42AS-382

Ras85DV12.sev has eye phenotype, enhanceable by Mi-2unspecified

Ras85DV12.sev has eye phenotype, enhanceable by aosΔ7/argos[+]

Ras85DV12.sev has ommatidium phenotype, enhanceable by aosΔ7/argos[+]

Ras85DV12.sev has ommatidium phenotype, enhanceable by rno2/rno[+]

Ras85DV12.sev has eye phenotype, enhanceable by rno2/rno[+]

Ras85DV12.sev has phenotype, enhanceable by ER2-8AXE-2684

Ras85DV12.sev has phenotype, enhanceable by ER2-7BXE-2847

Ras85DV12.sev has eye phenotype, enhanceable by ed[+]/ed1X5

Ras85DV12.sev has phenotype, enhanceable by lilliXS407/lilliXS407

Ras85DV12.sev has phenotype, enhanceable by lillis35

Ras85DV12.sev has phenotype, enhanceable by lilliXS575

Ras85DV12.sev has eye phenotype, enhanceable by EY2-5AH425

Ras85DV12.sev has eye phenotype, enhanceable by EY2-6AC403

Ras85DV12.sev has eye phenotype, enhanceable by retnB142

Ras85DV12.sev has eye phenotype, enhanceable by retnx1N793

Ras85DV12.sev has eye phenotype, enhanceable by EY3-3xBE183

Ras85DV12.sev has eye phenotype, enhanceable by EY3-4xII790

Ras85DV12.sev has eye phenotype, enhanceable by stgDD937

Ras85DV12.sev has eye phenotype, enhanceable by SM3-8SM3-8

Ras85DV12.sev has eye phenotype, enhanceable by SM3-6SM3-6

Ras85DV12.sev has eye phenotype, enhanceable by aopunspecified/aop[+]

Ras85DV12.sev has eye phenotype, enhanceable by SK2-3unspecified/SK2-3[+]

Ras85DV12.sev has eye phenotype, enhanceable by pp2c99B[+]/alphS-292

Ras85DV12.sev has eye phenotype, enhanceable by pp2c99B[+]/alphS-331

Ras85DV12.sev has eye phenotype, enhanceable by alphS-355/pp2c99B[+]

Ras85DV12.sev has eye phenotype, enhanceable by pp2c99B[+]/alphXS-88

Ras85DV12.sev has eye phenotype, enhanceable by Src42Aunspecified/Src42A[+]

Ras85DV12.sev has eye phenotype, enhanceable by PTP-ERXE-2776

Ras85DV12.sev has eye phenotype, enhanceable by PTP-ERXE-3022

Ras85DV12.sev has eye phenotype, enhanceable by Src42A15-1

Ras85DV12.sev has eye phenotype, enhanceable by Src42A18-2

Ras85DV12.sev has eye phenotype, enhanceable by Src42A7-4

Ras85DV12.sev has eye phenotype, enhanceable by Df(2R)nap8

Ras85DV12.sev has eye phenotype, enhanceable by Df(2R)nap9

Ras85DV12.sev has eye phenotype, enhanceable by Df(2R)nap1

Ras85DV12.sev has eye phenotype, enhanceable by In(2R)bwVDe2LCyR

Ras85DV12.sev has phenotype, enhanceable by cno3

Ras85DV12.sev has phenotype, enhanceable by mtsXE-2202

Ras85DV12.sev has phenotype, enhanceable by mtsXE-2258

Ras85DV12.sev has phenotype, enhanceable by ER2-1E-203

Ras85DV12.sev has phenotype, enhanceable by ER2-1E-33

Ras85DV12.sev has phenotype, enhanceable by ER2-3XE-2213

Ras85DV12.sev has phenotype, enhanceable by ER2-3XE-2542

Ras85DV12.sev has phenotype, enhanceable by ER2-4XE-2171

Ras85DV12.sev has phenotype, enhanceable by ER2-4XE-2866

Ras85DV12.sev has phenotype, enhanceable by Df(2R)XE-2900

Ras85DV12.sev has phenotype, enhanceable by PTP-ERXE12N

Ras85DV12.sev has phenotype, enhanceable by ER2-7AXE-2175

Ras85DV12.sev has phenotype, enhanceable by ER2-7AXE-2684

Ras85DV12.sev has phenotype, enhanceable by ER2-7BXE-2337

Ras85DV12.sev has phenotype, enhanceable by ER2-7BXE-2457

Ras85DV12.sev has phenotype, enhanceable by ER3-2XE-2551

Ras85DV12.sev has phenotype, enhanceable by ER3-2XE-2795

Ras85DV12.sev has phenotype, enhanceable by ER3-3XE-571

Ras85DV12.sev has phenotype, enhanceable by ER3-3XE-979

Ras85DV12.sev has phenotype, enhanceable by ER3-4XE-2178

Ras85DV12.sev has phenotype, enhanceable by ER3-4XE-2649

Ras85DV12.sev has phenotype, enhanceable by ER3-5XE-2335

Ras85DV12.sev has phenotype, enhanceable by ER3-5XE-2617

Ras85DV12.sev has phenotype, enhanceable by aopE-867

Ras85DV12.sev has phenotype, enhanceable by aopyan-XE18

Ras85DV12.sev has phenotype, enhanceable by hhXE-2134

Ras85DV12.sev has phenotype, enhanceable by hhXE-3161

Ras85DV12.sev has eye phenotype, enhanceable by mtsXE-2202

Ras85DV12.sev has eye phenotype, enhanceable by mtsXE-2258

NOT Enhanced by
Statement
Reference

Ras85DV12.sev has ommatidium phenotype, non-enhanceable by simj[+]/simjunspecified

Ras85DV12.sev has eye phenotype, non-enhanceable by Src42Ak10108

Ras85DV12.sev has ommatidium phenotype, non-enhanceable by Src42Ak10108

Ras85DV12.sev has phenotype, non-enhanceable by Shc111-40

Ras85DV12.sev has phenotype, non-enhanceable by ShcBG

Ras85DV12.sev has phenotype, non-enhanceable by EY2-5DW1080

Ras85DV12.sev has phenotype, non-enhanceable by EY2-6AQR618

Ras85DV12.sev has phenotype, non-enhanceable by Scer\GAL4[-]/EY2-8EP1160

Ras85DV12.sev has phenotype, non-enhanceable by EY2-8xCB204

Ras85DV12.sev has phenotype, non-enhanceable by EY3-2xAZ145

Ras85DV12.sev has phenotype, non-enhanceable by EY3-2xCF301

Ras85DV12.sev has phenotype, non-enhanceable by EY3-3xF6

Ras85DV12.sev has phenotype, non-enhanceable by EY3-4x1S805

Ras85DV12.sev has phenotype, non-enhanceable by EY3-5xKR845

Ras85DV12.sev has phenotype, non-enhanceable by EY3-5xZB970

Ras85DV12.sev has phenotype, non-enhanceable by Su(Tpl)DI998

Ras85DV12.sev has phenotype, non-enhanceable by Su(Tpl)EZ1217

Ras85DV12.sev has phenotype, non-enhanceable by lilliDE884

Ras85DV12.sev has phenotype, non-enhanceable by lilliDR999

Ras85DV12.sev has phenotype, non-enhanceable by Sin3ADW1046

Ras85DV12.sev has phenotype, non-enhanceable by SosxB10

Ras85DV12.sev has phenotype, non-enhanceable by eyaG130

Ras85DV12.sev has phenotype, non-enhanceable by glDZ1053

Ras85DV12.sev has phenotype, non-enhanceable by glER1085

Ras85DV12.sev has phenotype, non-enhanceable by pntAP553

Ras85DV12.sev has phenotype, non-enhanceable by spenAH393

Ras85DV12.sev has phenotype, non-enhanceable by stgD115

Ras85DV12.sev has phenotype, non-enhanceable by EM3-1EM3-1

Ras85DV12.sev has phenotype, non-enhanceable by SM2-1SM2-1

Ras85DV12.sev has phenotype, non-enhanceable by SM3-2SM3-2

Ras85DV12.sev has phenotype, non-enhanceable by SM3-3SM3-3

Ras85DV12.sev has phenotype, non-enhanceable by bulSF3-1

Ras85DV12.sev has phenotype, non-enhanceable by clnSF3-2

Ras85DV12.sev has phenotype, non-enhanceable by clnSF3-3

Ras85DV12.sev has phenotype, non-enhanceable by stySM3-5

Ras85DV12.sev has phenotype, non-enhanceable by stySM3-9

Ras85DV12.sev has eye phenotype, non-enhanceable by Egfr[+]/Egfrunspecified

Ras85DV12.sev has eye phenotype, non-enhanceable by Sunspecified/S[+]

Ras85DV12.sev has eye phenotype, non-enhanceable by Sosunspecified/Sos[+]

Ras85DV12.sev has eye phenotype, non-enhanceable by spenunspecified/spen[+]

Ras85DV12.sev has eye phenotype, non-enhanceable by Src42A1.15

Suppressed by
Statement
Reference

Ras85DV12.sev has eye phenotype, suppressible by rlE1171/rl+

Ras85DV12.sev has eye phenotype, suppressible by rl1/rl+

Ras85DV12.sev has eye phenotype, suppressible by Cka05836/Cka[+]

Ras85DV12.sev has eye phenotype, suppressible by gfzfCZ811/gfzf[+]

Ras85DV12.sev has eye phenotype, suppressible by CG1603[+]/CG1603f04743

Ras85DV12.sev has eye phenotype, suppressible by CG11266[+]/Caperf07714

Ras85DV12.sev has eye phenotype, suppressible by Prp19[+]/Prp19CE40

Ras85DV12.sev has eye phenotype, suppressible by rl[+]/rlS352

Ras85DV12.sev has eye phenotype, suppressible by CG748319/eIF4AIII[+]

Ras85DV12.sev has eye phenotype, suppressible by mago1/mago[+]

Ras85DV12.sev has eye phenotype, suppressible by mago[+]/mago2

Ras85DV12.sev has eye phenotype, suppressible by mago3/mago[+]

Ras85DV12.sev has eye phenotype, suppressible by tsu[+]/tsuEP567

Ras85DV12.sev has ommatidium phenotype, suppressible by klu[+]/kluunspecified

Ras85DV12.sev has eye phenotype, suppressible | partially by Df(2R)PC4/+

Ras85DV12.sev has ommatidium phenotype, suppressible | partially by Df(2R)PC4/+

Ras85DV12.sev has eye phenotype, suppressible | partially by edl[+]/edlk06602

Ras85DV12.sev has ommatidium phenotype, suppressible | partially by edl[+]/edlk06602

Ras85DV12.sev has eye phenotype, suppressible by Taf6[+]/Taf6XS-922

Ras85DV12.sev has eye phenotype, suppressible by Df(3L)kto2/+

Ras85DV12.sev has eye phenotype, suppressible | partially by Taf82270/Taf8[+]

Ras85DV12.sev has eye phenotype, suppressible | partially by Taf888-2/Taf8[+]

Ras85DV12.sev has eye phenotype, suppressible | partially by Taf888-6/Taf8[+]

Ras85DV12.sev has eye phenotype, suppressible | partially by Taf888/Taf8[+]

Ras85DV12.sev has ommatidium phenotype, suppressible by cswlf

Ras85DV12.sev has eye phenotype, suppressible by rin2/rin[+]

Ras85DV12.sev has eye phenotype, suppressible by rin1/rin[+]

Ras85DV12.sev has eye phenotype, suppressible by eyaA188

Ras85DV12.sev has eye phenotype, suppressible by rlA0648

Ras85DV12.sev has eye phenotype, suppressible by SosD120

Ras85DV12.sev has eye phenotype, suppressible by spenBU720

Ras85DV12.sev has eye phenotype, suppressible by Sin3ACY886

Ras85DV12.sev has eye phenotype, suppressible by EY3-2xDF411

Ras85DV12.sev has eye phenotype, suppressible by Taf4I53

Ras85DV12.sev has eye phenotype, suppressible by Taf4AG456

Ras85DV12.sev has eye phenotype, suppressible by SEM2-4

Ras85DV12.sev has ommatidium phenotype, suppressible by SEM2-4

Ras85DV12.sev has ommatidium phenotype, suppressible by SEF2-1

Ras85DV12.sev has eye phenotype, suppressible by SEF2-1

Ras85DV12.sev has eye phenotype, suppressible by 14-3-3εunspecified/14-3-3epsilon[+]

Ras85DV12.sev has eye phenotype, suppressible by EK2-5[+]/EK2-5unspecified

Ras85DV12.sev has eye phenotype, suppressible by EK2-7[+]/EK2-7unspecified

Ras85DV12.sev has eye phenotype, suppressible by EK3-3unspecified/EK3-3[+]

Ras85DV12.sev has eye phenotype, suppressible by kisunspecified/kis[+]

Ras85DV12.sev has eye phenotype, suppressible by ksrunspecified/ksr[+]

Ras85DV12.sev has eye phenotype, suppressible by pntunspecified/pnt[+]

Ras85DV12.sev has eye phenotype, suppressible by rl[+]/rlunspecified

Ras85DV12.sev has eye phenotype, suppressible by Dsor1[+]/Dsor1unspecified

Ras85DV12.sev has photoreceptor cell phenotype, suppressible by cnksag13L/sag[+]

Ras85DV12.sev has eye phenotype, suppressible by cnkXE-1040

Ras85DV12.sev has eye phenotype, suppressible by 14-3-3epsilon[+]/14-3-3εS-1259

Ras85DV12.sev has eye phenotype, suppressible by 14-3-3εS-696/14-3-3epsilon[+]

Ras85DV12.sev has phenotype, suppressible by eg28

Ras85DV12.sev has phenotype, suppressible by egGMR.PH

Ras85DV12.sev has phenotype, suppressible by cswG547E.hs.2sev

Ras85DV12.sev has phenotype, suppressible by βggt-IS-822

Ras85DV12.sev has phenotype, suppressible by βggt-IS-2554

Ras85DV12.sev has phenotype, suppressible by 14-3-3εS-1259

Ras85DV12.sev has phenotype, suppressible by 14-3-3εS-696

Ras85DV12.sev has phenotype, suppressible by Dsor1S-1221

Ras85DV12.sev has phenotype, suppressible by Dsor1XS520

Ras85DV12.sev has phenotype, suppressible by NS-125

Ras85DV12.sev has phenotype, suppressible by NS-317

Ras85DV12.sev has phenotype, suppressible by SR3-10S-124

Ras85DV12.sev has phenotype, suppressible by SR3-10S-297

Ras85DV12.sev has phenotype, suppressible by SR3-2S-432

Ras85DV12.sev has phenotype, suppressible by SR3-2XS-355

Ras85DV12.sev has phenotype, suppressible by Su(Tpl)S-192

Ras85DV12.sev has phenotype, suppressible by Su(Tpl)XS-706

Ras85DV12.sev has phenotype, suppressible by Taf1S-136

Ras85DV12.sev has phenotype, suppressible by Taf1XS-2232

Ras85DV12.sev has phenotype, suppressible by SR3-6S-122

Ras85DV12.sev has phenotype, suppressible by SR3-6XS-328

Ras85DV12.sev has phenotype, suppressible by SR3-7S-499

Ras85DV12.sev has phenotype, suppressible by SR3-7XS-5R

Ras85DV12.sev has phenotype, suppressible by SR3-8S-131

Ras85DV12.sev has phenotype, suppressible by Taf4S-117

Ras85DV12.sev has phenotype, suppressible by Df(3L)XS705

Ras85DV12.sev has phenotype, suppressible by ksrS-627

Ras85DV12.sev has phenotype, suppressible by ksrXS-337

Ras85DV12.sev has phenotype, suppressible by mamS-639

Ras85DV12.sev has phenotype, suppressible by mamXS-2295

Ras85DV12.sev has phenotype, suppressible by RafXS-2541

Ras85DV12.sev has phenotype, suppressible by phylS-221

Ras85DV12.sev has phenotype, suppressible by rlS-135

Ras85DV12.sev has phenotype, suppressible by rlXS-324

Ras85DV12.sev has phenotype, suppressible by rl10a

Ras85DV12.sev has phenotype, suppressible by Taf4S-466

Ras85DV12.sev has phenotype, suppressible by Taf4XS-2884

Ras85DV12.sev has eye phenotype, suppressible by TfIIA-SE73

Ras85DV12.sev has eye phenotype, suppressible by βggt-IS-2110

Ras85DV12.sev has eye phenotype, suppressible by βggt-IS-2126

Ras85DV12.sev has eye phenotype, suppressible by βggt-IS-483

Ras85DV12.sev has eye phenotype, suppressible by ksrS-511

Ras85DV12.sev has eye phenotype, suppressible by ksrS-548

Ras85DV12.sev has eye phenotype, suppressible by ksrS-638

Ras85DV12.sev has eye phenotype, suppressible by ksrS-69

Ras85DV12.sev has eye phenotype, suppressible by ksrS-721

Ras85DV12.sev has eye phenotype, suppressible by βggt-IS-2554

Ras85DV12.sev has eye phenotype, suppressible by E(sina)3K1

Ras85DV12.sev has eye phenotype, suppressible by glES5

Ras85DV12.sev has eye phenotype, suppressible by rlES7

Ras85DV12.sev has eye phenotype, suppressible by pnt07825Δ78

Ras85DV12.sev has eye phenotype, suppressible by Raf12

Ras85DV12.sev has eye phenotype, suppressible by Dsor1XS520

NOT suppressed by
Statement
Reference

Ras85DV12.sev has ommatidium phenotype, non-suppressible by simj[+]/simjunspecified

Ras85DV12.sev has phenotype, non-suppressible by Shc111-40

Ras85DV12.sev has phenotype, non-suppressible by ShcBG

Ras85DV12.sev has phenotype, non-suppressible by EY2-5DW1080

Ras85DV12.sev has phenotype, non-suppressible by EY2-6AQR618

Ras85DV12.sev has phenotype, non-suppressible by Scer\GAL4[-]/EY2-8EP1160

Ras85DV12.sev has phenotype, non-suppressible by EY2-8xCB204

Ras85DV12.sev has phenotype, non-suppressible by EY3-2xAZ145

Ras85DV12.sev has phenotype, non-suppressible by EY3-2xCF301

Ras85DV12.sev has phenotype, non-suppressible by EY3-3xF6

Ras85DV12.sev has phenotype, non-suppressible by EY3-4x1S805

Ras85DV12.sev has phenotype, non-suppressible by EY3-5xKR845

Ras85DV12.sev has phenotype, non-suppressible by EY3-5xZB970

Ras85DV12.sev has phenotype, non-suppressible by Su(Tpl)DI998

Ras85DV12.sev has phenotype, non-suppressible by Su(Tpl)EZ1217

Ras85DV12.sev has phenotype, non-suppressible by lilliDE884

Ras85DV12.sev has phenotype, non-suppressible by lilliDR999

Ras85DV12.sev has phenotype, non-suppressible by Sin3ADW1046

Ras85DV12.sev has phenotype, non-suppressible by SosxB10

Ras85DV12.sev has phenotype, non-suppressible by eyaG130

Ras85DV12.sev has phenotype, non-suppressible by glDZ1053

Ras85DV12.sev has phenotype, non-suppressible by glER1085

Ras85DV12.sev has phenotype, non-suppressible by pntAP553

Ras85DV12.sev has phenotype, non-suppressible by spenAH393

Ras85DV12.sev has phenotype, non-suppressible by stgD115

Ras85DV12.sev has phenotype, non-suppressible by SM2-1SM2-1

Ras85DV12.sev has phenotype, non-suppressible by SM3-2SM3-2

Ras85DV12.sev has phenotype, non-suppressible by SM3-3SM3-3

Ras85DV12.sev has phenotype, non-suppressible by bulSF3-1

Ras85DV12.sev has phenotype, non-suppressible by clnSF3-2

Ras85DV12.sev has phenotype, non-suppressible by clnSF3-3

Ras85DV12.sev has phenotype, non-suppressible by stySM3-5

Ras85DV12.sev has phenotype, non-suppressible by stySM3-9

Ras85DV12.sev has phenotype, non-suppressible by EM3-1EM3-1

Ras85DV12.sev has eye phenotype, non-suppressible by Egfr[+]/Egfrunspecified

Ras85DV12.sev has eye phenotype, non-suppressible by Sunspecified/S[+]

Ras85DV12.sev has eye phenotype, non-suppressible by Sosunspecified/Sos[+]

Ras85DV12.sev has eye phenotype, non-suppressible by spenunspecified/spen[+]

Enhancer of
Statement
Reference

Ras85DV12.sev is an enhancer of phenotype of svp1.sev

Ras85DV12.sev is an enhancer of phenotype of svp2.sev

NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference

Ras85DV12.sev is a non-suppressor of ommatidium | somatic clone phenotype of cnksag13L

Ras85DV12.sev is a non-suppressor of rhabdomere | somatic clone phenotype of cnksag13L

Ras85DV12.sev is a non-suppressor of eye phenotype of rprGMR.PW

Ras85DV12.sev is a non-suppressor of phenotype of hidAla5.GMR

Ras85DV12.sev is a non-suppressor of phenotype of hidAla3.GMR

Ras85DV12.sev is a non-suppressor of eye phenotype of grimGMR.PC

Other
Additional Comments
Genetic Interactions
Statement
Reference

holn1c07150/+ enhances the Ras85DV12.sev rough eye phenotype.

The rough eye phenotype caused by Ras85DV12.sev is dominantly suppressed by rlS352, eIF4AIII19, mago1, mago2, mago3 or tsuEP567.

The rough eye phenotype of Ras85DV12.sev mutants is increased when transheterozygous with alphS-355.

The rough eye phenotype of Ras85DV12.sev flies is moderately suppressed by expression of Ppm1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.2sev.

The rough eye phenotype caused by Ras85DV12.sev is suppressed by kluunspecified/+.

Ras85DV12.sev, cnkhs.sev.T:Zzzz\FLAG double mutants have an average of 1.2 R7 cells per ommatidium. Ras85DV12.sev, cnkΔRIM.hs.sev.T:Zzzz\FLAG double mutants have an average of 2.7 R7 cells per ommatidium.

The rough eye phenotype of Ras85DV12.sev flies is enhanced by rno2/+ and by argosΔ7/+.

Expression of edlScer\UAS.cYa under the control of Scer\GAL4hs.2sev suppresses the ectopic R7 neurons caused by expression of Ras85DV12.sev.

One copy of mask10.22 weakly suppresses the Ras85DV12.sev rough eye phenotype.

The rough eye phenotype of Ras85DV12.sev flies is dominantly suppressed by Taf6XS-922 and by Df(3L)kto2. The increased number of R7 photoreceptor cells per ommatidium that is seen in Ras85DV12.sev flies is suppressed from 3.1 to 1.5 by Taf6XS-922/+.

The supernumerary R7 cell and rough eye phenotype produced by Ras85DV12.sev is suppressed by cswlf.

Expression of CblDv.Scer\UAS in the eye under the control of Scer\GAL4GMR.PF in combination with Ras85DV12.sev at 25[o]C produces melanotic tumours in the eyes in approximately 30% of progeny.

All of the ommatidia in flies expressing svpScer\UAS.cKa under the control of Scer\GAL4sca-537.4 lack R7 and R8 photoreceptor cells. The formation of R7 cells is rescued in these flies by expression of Ras85DV12.sev.

The rough eye phenotype is enhanced by PTP-ERXE-3022 and PTP-ERXE-2776. Ectopic expression of PTP-ERhs.sev in the eye completely blocks the Ras85DV12.sev rough eye phenotype even in the presence of PTP-ERXE-3022.

The rough eye phenotype of Ras85DV12.sev is not enhanced by Src42A1.15. The rough eye phenotype of Ras85DV12.sev is enhanced by Src42A15-1, Src42A18-2, Src42A7-4, Df(2R)nap8, Df(2R)nap9, Df(2R)nap1 or In(2R)bwVDe2LCyR. Lethality at the pupal stage is seen in Src42ASu(phl)1-1 Ras85DV12.sev double heterozygotes.

The Ras85DV12.sev extra R7 photoreceptor cell phenotype is dominantly suppressed by sag13L.

Suppresses the eye reduction phenotype caused by rprGMR.PW. Suppresses the eye reduction phenotype caused by WGMR.PG.

Ras85DV12.sev in combination with sevS11.T:Hsap\MYC results in synthetic lethality. Expression of sevS11.T:Hsap\MYC above a certain level in embryos results in lethality and this lethality is enhanced by co-expression of Ras85DV12.sev. The lethality is sensitive to the expression levels of both sevS11.T:Hsap\MYC and Ras85DV12.sev. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by Trl62, trxunspecified, Df(2L)JK12, skd2, osa2, mor1, kto1, kis1, kis2, brm1, brm2, Df(3R)red-P52, RpII140AS, RpII15V, SR3-8XS-701, SR3-8S-959, SR3-7XS-17N, SR3-7S-499, Taf1XS-2232, Taf1S-625, Su(Tpl)S-705, Su(Tpl)S-192, Taf4S-466, Taf4XS-793, Taf6XS-922, Sose4G, Ras85De1B, Ras85DE4, rlXS-2275, rlXS-2442, ksrXS-2424, ksrXS-2832, phyl2829, phyl2245, βggt-IS-2554, mamS-176, Df(3R)293γ5, Df(2L)ast2, Df(2R)nap9, Df(2R)pk78c or Df(3L)vin2. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by l(3)0624006240, l(3)0626506265, l(3)0929109291, Rpd304556, l(3)0514305143, btl00208, btl04727, frc10098, ftz-f103649, eRF105637, l(3)77CDf04521, tws02414, tws06848, l(3)0360803608, l(3)0665806658, osa04539, fray07551, l(3)0582005820, InR05545, pnt04263b, pnt07825, l(3)0307703077, l(3)0470804708, l(3)0674306743 or l(3)0673406734. The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by the l(3)06948 line (l(3)06948a06948a and sr06948b), by the l(3)03745 line (tws03745a and Dl03745b) and by the l(3)04704 line (l(3)04704a04704a and l(3)04704b04704b). The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by TfIIA-SE32, ash12, Vha5515, Vha5516, mor2, osa1, sls1, skd1, Df(3R)urd, urd2, vtd3, Pc3 or Pc4.

The rough eye and extra R7 cell phenotype is dominantly suppressed by 14-3-3εS-1259 and 14-3-3εS-696 and recessively suppressed by 14-3-3εj2B10. Df(3R)P14 shows no dominant interaction with Ras85DV12.sev. Heterozygosity for 14-3-3ζP2355 does not alter the Ras85DV12.sev phenotype.

Loss of cno+ activity (cno3 or Df(3R)6-7) does not affect overproduction of R7 cells in Ras85DV12.sev flies but loss of pigment cells is more severe and supernumerary cone cells appear (these cone cells are recruited from a pool of retinal precursors that normally develop into pigment cells and from cells to be eliminated by apoptosis). The phl1 mutation completely suppresses the overproduction of cone cells triggered by the Ras85DV12.sev and cno3 interaction.

Extra R7-cell phenotype is suppressed by cswG547E.hs.2sev.

lzr1/lz+; P{sevRas1.V12} flies display an external eye phenotype and cone to R7 cell conversion indistinguishable from P{sevRas1.V12}.

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

Ras85DV12.sev; Df(2R)rl10a/+ flies have smooth eyes with a greatly reduced number of R7 cells.

pnt07825Δ78 acts as a dominant suppressor of the eye phenotype of the activated Ras85DV12.sev.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (255)
Notes on Origin
Discoverer
Comments
Comments

Activated Ras85D construct whose expression is governed by a sev enhancer.

Strongly activated Ras85D phenotype.

This allele has been used as a starting point to identify components of the Ras1 signaling pathway, by isolating second site dominant suppressors and enhancers of the rough-eye phenotype.

Constitutively active.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
Reported As
Symbol Synonym
Name Synonyms
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    References (95)