HomeAllele Dmel\Ras85DV12.sev
| General Information | |||
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| Symbol | Dmel\Ras85DV12.sev | Species | D. melanogaster |
| Name | FlyBase ID | FBal0033983 | |
| Feature type | allele | Created / Updated | 2006-08-20/2006-08-20 |
| Associated gene | Dmel\Ras85D | ||
| Allele class | hypomorph, gain of function | ||
| Mutagen | in vitro construct | regulatory fusion | ||
Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mapped Features and Mutations | |||
Type Symbol & Location Additional Notes References | |||
| Associated Sequence Data | |||
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
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| Progenitor genotype | |||
| Nature of the lesion | Statement Reference | ||
| Assay mode | |||
| Carried in construct | (Brunner et al., 1994, Yamada et al., 2003, Tootle et al., 2003, Rintelen et al., 2003, Smith et al., 2002, Read et al., 2005, Fetchko et al., 2002, Friedman and Perrimon, 2006, Behan et al., 2002, Yamamoto, 1993, Simon et al., 1992, Simon et al., 1993, Bohmann et al., 1994, Douziech et al., 2003, Chang et al., 1995, Pazman et al., 2000, Voas and Rebay, 2003, Huang and Rubin, 2000, Tang et al., 2001, Rebay et al., 2000, Bai et al., 2001, Zhang and Lu, 2000, Begemann et al., 1995, Carthew et al., 1994, Taguchi et al., 2000, Huang and Rubin, 2000, Luschnig et al., 2000, Therrien et al., 1999, Chou et al., 1999, Maixner et al., 1998, Karim and Rubin, 1999, Casci et al., 1999, Asha et al., 1999, Thomas and Wassarman, 1999, Lu and Li, 1999, Laberge et al., 2005, Zhang et al., 1999, Li et al., 1997, Therrien et al., 2000, Firth et al., 2000, Yamamoto et al., 1997, Fortini et al., 1992, Lai and Rubin, 1992, Rusconi et al., 2004, Bergmann et al., 1998, Karim et al., 1996, Daga et al., 1996, Allard et al., 1996, Wassarman et al., 1996, Wernet et al., 2003, Zeidler et al., 1996, Therrien et al., 1995, Chang et al., 1994, Sauer et al., 1996, Matsuo et al., 1997, Karim and Rubin, 1997, Kauffmann et al., 1996, van der Straten et al., 1997, Lim et al., 1997, Hay et al., 1997, Kockel et al., 1997, Chang and Rubin, 1997, Sawamoto et al., 1996, Kon, 2005, Peverali et al., 1996, Rubin et al., 1997, Kim et al., 2006, Baril and Therrien, 2006) | ||
| Cytology | |||
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Phenotypic Data
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Phenotypic Class
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(Lu and Li, 1999, Bai et al., 2001, Maixner et al., 1998, Rusconi et al., 2004, Firth et al., 2000, Hay et al., 1997, Kurada and White, 1998, Taguchi et al., 2000, Hernandez-Hernandez and Ferrus, 2001, Friedman and Perrimon, 2006, Read et al., 2005, Rebay et al., 2000, Smith et al., 2002, Kon, 2005, van der Straten et al., 1997, Karim and Rubin, 1999, Therrien et al., 1999, Luschnig et al., 2000, Pazman et al., 2000, Tootle et al., 2003) | |||
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Phenotype Manifest In
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(Read et al., 2005, Chang and Rubin, 1997, Therrien et al., 1995, Douziech et al., 2003, Bai et al., 2001, Karim et al., 1996, Lu and Li, 1999, Wassarman et al., 1996, Huang and Rubin, 2000, Laberge et al., 2005, Baril and Therrien, 2006, Luschnig et al., 2000, Therrien et al., 1998, van der Straten et al., 1997, Therrien et al., 1999, Hernandez-Hernandez and Ferrus, 2001, Kurada and White, 1998, Chang et al., 1995, Voas and Rebay, 2003, Friedman and Perrimon, 2006, Rebay et al., 2000, Pazman et al., 2000, Maixner et al., 1998, Zeidler et al., 1996, Tootle et al., 2003, Brunner et al., 1994, Taguchi et al., 2000, Karim and Rubin, 1999) | |||
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Detailed Description
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Statement Reference Rough eye phenotype, 75% ommatidia contain supernumerary R7-like cells, at the expense of cone cell precursors. Rough eye phenotype, most ommatidia contain supernumerary R7 cells, aberrant packing and rotation of ommatidia, occasional extra or missing R1-R6 cells and missing pigment cells. Homozygous drkE(sev)2B clones in P{sevRas1.V12} flies frequently develop as photoreceptors despite the lack of drk function. The rescued cells can be inner R1-R6-like photoreceptors or outer R7-like photoreceptors. Rough eyes due to multiple R7 cells. Rough eye phenotype is suppressed by JrabZIP.hs.sev.T:Ivir\HA1. Rough eye phenotype, more severe in flies bearing two copies. Cone cell precursors are transformed into supernumerary R7 cells. Only 2% of ommatidia in the center of the eye are wild type. Flies with two copies of Ras85DV12.sev have a more extreme rough eye phenotype than flies with one copy. External roughening of the eye, three to four cone cells in each ommatidia are converted to R7 cells. Rough eye phenotype. Ommatidia differentiate additional R7 cells. Overexpression of argos (P{hs-argos.S}) or decrease in gene dosage (argos257) fail to affect the multiple R7 phenotype. Transforms nonneuronal cone cells into R7 photoreceptor cells, these extra R7 cells disrupt the normal packing of cells in ommatidia resulting in an external roughening of the eye. Flies carrying Ras85DV12.sev have rough eyes, and some of the four cone cell precursors are transformed into extra R7 photoreceptor cells. Flies carrying two copies of Ras85DV12.sev have rougher eyes than flies carrying one copy of Ras85DV12.sev. Rough eye phenotype associated with extra R7 photoreceptors and ommatidial fusions. Homozygous 14-3-3ζE16 clones are not recovered in flies carrying Ras85DV12.sev. Rough eye phenotype is not suppressed by mutations of Hsp83. Strong rough eye phenotype due to multiple R7 cells and induction of supernumerary cone cells. Rough eye phenotype. Rough eye phenotype. Flies carrying Ras85DV12.sev have a rough eye phenotype. Flies carrying Ras85DV12.sev have extra R7 photoreceptor cells. The Ras85DV12.sev phenotype is unaffected by halving the dose of sty+. Expression causes a rough eye phenotype. Eye surface is roughened. Flies carrying Ras85DV12.sev have a rough eye phenotype caused by excess R7 cells and destruction of the regular ommatidial array. Flies carrying Ras85DV12.sev have a rough eye phenotype. Flies carrying Ras85DV12.sev have supernumerary R7 cells and a rough eye phenotype. Rough eye phenotype. 90% of ommatidia have supernumerary R7 cells. Transforms cone cells into R7 cells. Expression of Ras85DV12.sev leads to the transformation of cone cells into R7 photoreceptors. Rough eye phenotype. Flies carrying Ras85DV12.sev have a rough eye phenotype. Flies carrying Ras85DV12.sev have a rough eye phenotype, with an average of 3.0 R7 cells per ommatidium. Flies expressing Ras85DV12.sev have extra R7 photoreceptors in the eye. Expression of Ras85DV12.sev transforms cone cells in R7 neurons. Mutant animals exhibit a rough eye phenotype. Ommatidia have an average of 1.9 R7 cells compared to 1 per ommatidium in wild-type. Ras85DV12.sev flies have rough eyes. Expression of Ras85DV12.sev results in extra photoreceptor R7 cells throughout the retina. Extra photoreceptor R7 cells are induced in the dorsal rim area (DRA) of the eye. Adults carrying Ras85DV12.sev have a rough eye phenotype. Mutant animals have a rough eye phenotype. Ras85D[V12.sev]/+ mutants exhibit a mild rough eye phenotype. Ras85D[V12.sev] flies have a rough eye phenotype. | |||
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Interactions
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Phenotypic Class
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| Enhanced by | |||
Statement Reference | |||
| NOT Enhanced by | |||
Statement Reference | |||
| Suppressed by | |||
Statement Reference Ras85DV12.sev, sevS11.T:Hsap\MYC has lethal phenotype, suppressible by l(3)04704b04704b/l(3)04704a04704a Ras85DV12.sev has visible phenotype, suppressible | partially by Ppm1Scer\UAS.T:Ivir\HA1/Scer\GAL4hs.2sev | |||
| NOT suppressed by | |||
Statement Reference | |||