FB2025_01 , released February 20, 2025
Allele: Dmel\Sod1+t2.4
Open Close
General Information
Symbol
Dmel\Sod1+t2.4
Species
D. melanogaster
Name
FlyBase ID
FBal0034020
Feature type
allele
Associated gene
Dmel\Sod1
Associated Insertion(s)
Carried in Construct
P{Sod1+2.4}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Orr and Sohal, 1993)
wild_type
(Orr and Sohal, 1993)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Orr and Sohal, 1993)
wild_type
(Orr and Sohal, 1993)
Mutagen
in vitro construct
(Sohal et al., 1995, Orr and Sohal, 1994, Orr and Sohal, 1993)
Progenitor genotype
Carried in construct
P{Sod1+2.4}
Cytology
Description

Contained within a 2.4kb genomic EcoRI fragment that includes the entire coding region of Sod1 as well as 0.8kb of sequence upstream from the start codon.

(Orr and Sohal, 1993)
Allele components
Component
Use(s)
Regulatory region(s)
Sod1
Encoded product / tool
Sod1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3L:11,112,209..11,114,712 [-]
Linked to:
EcoRI-EcoRI restriction fragment
Comment:

position of restriction fragment on reference sequence inferred by FlyBase curator

(Orr and Sohal, 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying both one copy of Sod+t2.4 and one copy of CattOa show a retardation in the accumulation of 8-hydroxydeoxyguanosine during aging and in response to exposure to X rays compared to control flies. Age-related loss of Zw activity and increase in the rate of mitochondrial H2O2 generation are less steep in flies carrying both one copy of Sod+t2.4 and one copy of CattOa than in control flies. The metabolic potential, or total amount of oxygen consumed during an average lifespan, is approximately 30% greater in flies carrying both one copy of Sod+t2.4 and one copy of CattOa than in control flies.

      (Sohal et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Sod1+t2.4, CattOa, Trxr1+t10 is a suppressor of chemical sensitive phenotype of Ppcs1

      (Bosveld et al., 2008)

      Sod1+t2.4, CattOa, Trxr1+t10 is a suppressor of chemical sensitive phenotype of fbl1

      (Bosveld et al., 2008)
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Simultaneous co-expression of Sod+t2.4, CattOa and Trxr-1+t10 suppresses the sensitivity of Ppcs1/Ppcs1 flies to 5% H[[2]]O[[2]] and 100mM dithiothreitol, and results in increased resistance to 20mM paraquat.

      Simultaneous co-expression of Sod+t2.4, CattOa and Trxr-1+t10 restores survival of Ppcs1/Ppcs1 and fbl1/fbl1 larvae on medium containing 100mM cysteine to wild-type levels.

      Simultaneous co-expression of Sod+t2.4, CattOa and Trxr-1+t10 does not suppress the impaired ability of Ppat-Dpck43 or Ppcs1 homozygous adults to climb in a negative geotaxis assay.

      The reduced survival rate of adults after exposure of larvae to 20Gy irradiation that is seen in Ppcs1 homozygotes is not rescued by simultaneous co-expression of Sod+t2.4, CattOa and Trxr-1+t10.

      (Bosveld et al., 2008)

      Expression of both CattOa and Sod+t2.4 does not result in an increase in life span. Co-expression of CattOa, Sod+t2.4 and Sod2+t9 does not result in an increase in life span. Expression of both Trxr-1+t10 and Sod+t2.4 does not result in an increase in life span.

      (Orr et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sod1+t2.4
      Sod+t2.4
      Name Synonyms
      Secondary FlyBase IDs
        References (6)