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General Information
Symbol
Dmel\Dsor1XS520
Species
D. melanogaster
Name
FlyBase ID
FBal0034021
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dsor1XS-520
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Reported as in frame deletion of M308 and A309 in FBrf0087493. Maps to M311 and A312 in the CDS encoded by the reference sequence. The difference is due to the use of an upstream splice acceptor in an upstream intron. The annotated version is supported by full length cDNA LD41207 (GB:AY058692).

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

6bp in frame deletion removing M308 and A309 of the kinase subdomain X, both of which are conserved in mammalian MEK.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Dsor1XS520 is a weak mutation which results in a loss of R7 and some outer photoreceptor cells causing mild eye roughness.

Rough eye phenotype resulting from a failure of a proportion of R7 cells and outer photoreceptor cells to differentiate. Parts of some wing veins are missing.

Some ommatidia lack R7 cells. ttk mutations have no significant effect on the severity of the rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Dsor1XS520 has visible phenotype, enhanceable by hhXE-2134

Dsor1XS520 has visible phenotype, enhanceable by hhXE-3161

Dsor1XS520 has visible phenotype, enhanceable by ksrS-627

Dsor1XS520 has visible phenotype, enhanceable by ksrXS-337

Dsor1XS520 has visible phenotype, enhanceable by mamS-639

Dsor1XS520 has visible phenotype, enhanceable by mamXS-2295

Dsor1XS520 has visible phenotype, enhanceable by rlS-135

Dsor1XS520 has visible phenotype, enhanceable by rlXS-324

Dsor1XS520 has visible phenotype, enhanceable by SR3-6S-122

Dsor1XS520 has visible phenotype, enhanceable by SR3-6XS-328

Dsor1XS520 has visible phenotype, enhanceable by Taf6XS-922

Dsor1XS520 has visible phenotype, enhanceable by ER2-7BXE-2337

Dsor1XS520 has visible phenotype, enhanceable by ER2-7BXE-2457

Dsor1XS520 has visible phenotype, enhanceable by ER3-4XE-2178

Suppressed by
Statement
Reference

Dsor1XS520 has visible | recessive phenotype, suppressible by Src42ASu(Raf)1-1

Dsor1XS520 has visible phenotype, suppressible by ER2-1E-203

Dsor1XS520 has visible phenotype, suppressible by ER2-1E-33

Dsor1XS520 has visible phenotype, suppressible by ER2-3XE-2542

Dsor1XS520 has visible phenotype, suppressible by ER2-4XE-2171

Dsor1XS520 has visible phenotype, suppressible by ER2-4XE-2866

Dsor1XS520 has visible phenotype, suppressible by ER3-2XE-2795

Dsor1XS520 has visible phenotype, suppressible | partially by mtsXE-2202

Dsor1XS520 has visible phenotype, suppressible by mtsXE-2258

Dsor1XS520 has visible phenotype, suppressible by PTP-ERXE12N

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

Dsor1XS520 has eye phenotype, enhanceable by hhXE-2134

Dsor1XS520 has eye phenotype, enhanceable by hhXE-3161

Dsor1XS520 has eye phenotype, enhanceable by ksrS-627

Dsor1XS520 has eye phenotype, enhanceable by ksrXS-337

Dsor1XS520 has eye phenotype, enhanceable by mamS-639

Dsor1XS520 has eye phenotype, enhanceable by mamXS-2295

Dsor1XS520 has eye phenotype, enhanceable by rlS-135

Dsor1XS520 has eye phenotype, enhanceable by rlXS-324

Dsor1XS520 has eye phenotype, enhanceable by SR3-6S-122

Dsor1XS520 has eye phenotype, enhanceable by SR3-6XS-328

Dsor1XS520 has eye phenotype, enhanceable by Taf6XS-922

Dsor1XS520 has eye phenotype, enhanceable by ER2-7BXE-2337

Dsor1XS520 has eye phenotype, enhanceable by ER2-7BXE-2457

Dsor1XS520 has eye phenotype, enhanceable by ER3-4XE-2178

Dsor1XS520 has eye phenotype, enhanceable by pnt07825Δ78

Suppressed by
Statement
Reference

Dsor1XS520 has eye phenotype, suppressible by PTP-ERXE-2776

Dsor1XS520 has ommatidium phenotype, suppressible by PTP-ER[-]

Dsor1XS520 has eye phenotype, suppressible by PTP-ER[-]

Dsor1XS520 has eye photoreceptor cell phenotype, suppressible by PTP-ER[-]

Dsor1XS520 has photoreceptor cell R7 phenotype, suppressible by PTP-ER[-]

Dsor1XS520 has eye phenotype, suppressible by PTP-ERXE-3022

Dsor1XS520 has eye phenotype, suppressible by Src42ASu(Raf)1-1

Dsor1XS520 has phenotype, suppressible by aopE-867

Dsor1XS520 has phenotype, suppressible by aopyan-XE18

Dsor1XS520 has eye phenotype, suppressible by ER2-1E-203

Dsor1XS520 has eye phenotype, suppressible by ER2-1E-33

Dsor1XS520 has eye phenotype, suppressible by ER2-3XE-2542

Dsor1XS520 has eye phenotype, suppressible by ER2-4XE-2171

Dsor1XS520 has eye phenotype, suppressible by ER2-4XE-2866

Dsor1XS520 has eye phenotype, suppressible by ER3-2XE-2795

Dsor1XS520 has eye phenotype, suppressible | partially by mtsXE-2202

Dsor1XS520 has eye phenotype, suppressible by mtsXE-2258

Dsor1XS520 has eye phenotype, suppressible by PTP-ERXE12N

NOT Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

Dsor1XS520 is a suppressor of hemocyte | increased number phenotype of hopTum

Dsor1XS520 is a suppressor of phenotype of Ras85DV12.sev

Dsor1XS520 is a suppressor of eye phenotype of Ras85DV12.sev

NOT Suppressor of
Statement
Reference

Dsor1XS520 is a non-suppressor of eye phenotype of CanBGMR.PS, Pp2B-14Dact.GMR

Additional Comments
Genetic Interactions
Statement
Reference

Dsor1XS520 blocks differentiation of hopTum blood cells into lamellocytes and the increased accumulation of blood cells seen in hopTum larvae is strongly inhibited in the double mutant larvae.

Heterozygous PTP-ERXE-3022, PTP-ERXE-2776 as well as deficiency alleles of PTP-ER suppress the rough eyes and loss of photoreceptor cells seen in hemizygous Dsor1XS520.

Src42ASu(phl)1-1 dominantly suppresses the rough eye phenotype of Dsor1XS520.

Suppresses the rough eye phenotype of Ras85DV12.sev. Enhances the phenotype of Ras85DN17.sev. Suppresses the phenotype of phl::tor13D.hs.sev. Suppresses the phenotype of Ras85D::Src64BV12.ΔCAAX.sev. Enhances the aopS2382 eye phenotype.

Acts as a dominant suppressor of the activated Ras85DV12.sev. Halving the gene dosage of pnt enhances both the rough eye and missing photoreceptor phenotypes of Dsor1XS520 and phl12.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)