FlyBase Allele Report: Dmel\aop[yan-1]

Imprecise excision of the P-element, deletion extends from within the P-element to flanking genomic DNA causing a small deletion near the insertion site.

(Lai and Rubin, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with aop^A141)

(Weber et al., 2008)

abnormal planar polarity (with aop^e2d)

(Weber et al., 2008)

female sterile

(Lai and Rubin, 1992)

male sterile

(Lai and Rubin, 1992)

partially lethal

(Lai and Rubin, 1992)

partially lethal - majority die (with aop^e2d)

(Rogge et al., 1995)

partially lethal - majority die (with Df(2L)dp-79b)

(Rogge et al., 1995)

partially lethal - majority die | recessive

(Rogge et al., 1995)

visible

(Rogge et al., 1995)

visible (with aop^e2d)

(Rogge et al., 1995)

visible (with aop^pok-x8)

(Rogge et al., 1995)

visible (with Df(2L)dp-79b)

(Rogge et al., 1995)

visible | recessive

(Lai and Rubin, 1992)

Phenotype Manifest In

border follicle cell | somatic clone

(Schober et al., 2005)

cone cell | precursor

(Lai and Rubin, 1992)

embryonic/larval oenocyte | increased number

(Brodu et al., 2004)

embryonic somatic muscle cell

(Bidet et al., 2003)

eye

(Rogge et al., 1995, Lai and Rubin, 1992)

eye photoreceptor cell

(Lai and Rubin, 1992)

eye photoreceptor cell | cell autonomous | somatic clone

(Lai and Rubin, 1992)

larval tracheal system

(Lai and Rubin, 1992)

midline glial cell

(Scholz et al., 1997, Scholz et al., 1997)

ommatidium

(Zhang and Lu, 2000, Kauffmann et al., 1996, Rogge et al., 1995, Lai and Rubin, 1992)

ommatidium (with aop^A141)

(Weber et al., 2008)

ommatidium (with aop^e2d)

(Weber et al., 2008, Rogge et al., 1995)

ommatidium (with aop^pok-x8)

(Rogge et al., 1995)

ommatidium (with Df(2L)dp-79b)

(Rogge et al., 1995)

photoreceptor cell R1

(Zhang and Lu, 2000)

photoreceptor cell R1 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R2

(Zhang and Lu, 2000)

photoreceptor cell R2 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R3

(Zhang and Lu, 2000)

photoreceptor cell R3 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R4

(Zhang and Lu, 2000)

photoreceptor cell R4 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R5

(Zhang and Lu, 2000)

photoreceptor cell R5 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R6

(Zhang and Lu, 2000)

photoreceptor cell R6 | ectopic

(Zhang and Lu, 2000)

photoreceptor cell R7

(Chang et al., 1995, Dickson et al., 1995)

photoreceptor cell R7 | ectopic

(Behan et al., 2002, Zhang and Lu, 2000)

photoreceptor cell R7 | ectopic (with aop^pok-x8)

(Rogge et al., 1995)

segment border muscle cell

(Bidet et al., 2003)

Detailed Description

Statement

Reference

aop^yan-1/aop^A141 eye discs show chirality defects in 9.4% of ommatidial clusters.

aop^yan-1/aop^e2d eye discs show chirality defects in ommatidial clusters.

(Weber et al., 2008)

Border cell migration is significantly delayed in egg chambers with aop^yan-1 mitotic clones.

(Schober et al., 2005)

Stage 16 aop^yan-1 homozygous embryos have more oenocytes per cluster than wild-type. Unlike rho^{Scer\UAS.cdCa}; Scer\GAL4^en-e16E the oenocyte clusters in these embryos do not show a multi-modal distribution of cell numbers with peaks corresponding to multiples of 3, suggesting that normal delamination cycles in groups of 3 are not occurring.

(Brodu et al., 2004)

Mutant embryos show an increase in the number of lateral adult muscle precursors and the segmental border muscle fibres are enlarged.

(Bidet et al., 2003)

Ectopic R7 development, which is precocious relative to the morphogenetic furrow, is seen in third instar eye discs.

(Behan et al., 2002)

In aop^yan-1 mutants 90% of the ommatidia contain between one and four (average 2.0) supernumerary R7-like cells. 27% of the ommatidia contain one or two extra outer photoreceptor cells, while 6% of the ommatidia lack one or two outer photoreceptor cells.

(Zhang and Lu, 2000)

14-3-3ε^S-696 does not show any dominant interaction with aop^yan-1.

(Chang and Rubin, 1997)

Embryos exhibit a reduction in number of midline glial cells.

(Scholz et al., 1997, Scholz et al., 1997)

The formation of extra R7 cells in aop mutants is independent of lilli.

(Dickson et al., 1996)

Suppressed by phyl²³⁶⁶. The phyl²³⁶⁶ mutation completely suppresses the supernumerary R7 phenotype of aop and Gap1 mutations.

(Chang et al., 1995)

The formation of additional R7 cells requires phyl⁺.

(Dickson et al., 1995)

Adult escapers exhibit a mild rough eye phenotype. Transheterozygotes with Df(2L)dp-79b or aop^e2d are also semi-lethal with escapers exhibiting a mild rough eye phenotype. Transheterozygotes with aop^pok-x8 are viable with mild rough eyes.

(Rogge et al., 1995)

Homozygotes have reduced viability and fertility, about 20% reach adulthood. Embryos have abnormalities in germband retraction and tracheal structure. Homozygotes exhibit a rough eye phenotype, 88% ommatidia contain between 1 and 4 supernumerary R7-like cells, at the expense of cone cell precursors, some of the ommatidia also contain extra outer photoreceptor cells and fewer have a reduced number of outer photoreceptor cells. Hemizygotes exhibit the same phenotype. Eye discs exhibit two classes of defects: extra elav-positive cells begin to appear at an early stage of ommatidial development and irregular spacing and orientation of ommatidia. Mosaic analysis demonstrates the mutation acts cell-autonomously to generate supernumerary R7 cells.

(Lai and Rubin, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

aop^yan-1/aop[+] is an enhancer of visible phenotype of faf^BX4

(Isaksson et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

aop^yan-1 has phenotype, suppressible by Sos^EY2-3

(Chen et al., 1999)

aop^yan-1 has phenotype, suppressible by pros^JO1

(Kauffmann et al., 1996)

Enhancer of

Statement

Reference

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R7 | ectopic phenotype of sty²²⁶

(Kramer et al., 1999)

aop^yan-1 is an enhancer of photoreceptor cell R1 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1 is an enhancer of photoreceptor cell R2 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1 is an enhancer of photoreceptor cell R3 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1 is an enhancer of photoreceptor cell R4 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1 is an enhancer of photoreceptor cell R5 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1 is an enhancer of photoreceptor cell R6 | ectopic phenotype of B-H1^sev.PH

(Hayashi et al., 1998)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R1 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R2 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R3 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R4 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R5 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1/aop[+] is an enhancer of photoreceptor cell R6 | ectopic phenotype of faf^BX4

(Isaksson et al., 1997)

aop^yan-1 is an enhancer of phenotype of svp^2.sev

(Begemann et al., 1995)

aop^yan-1 is an enhancer of phenotype of svp^1.sev

(Begemann et al., 1995)

aop^yan-1 is an enhancer of phenotype of Jra^Asp.hs.sev

(Treier et al., 1995)

aop^yan-1 is an enhancer of eye phenotype of rho^hs.sev

(Freeman, 1994)

Suppressor of

Statement

Reference

aop^yan-1 is a suppressor of ommatidium | somatic clone phenotype of cnk^sag13L

(Zhang and Lu, 2000)

aop^yan-1 is a suppressor of photoreceptor cell R1 | somatic clone phenotype of cnk^sag13L

(Zhang and Lu, 2000)

aop^yan-1 is a suppressor of photoreceptor cell R6 | somatic clone phenotype of cnk^sag13L

(Zhang and Lu, 2000)

aop^yan-1 is a suppressor of photoreceptor cell R7 | somatic clone phenotype of cnk^sag13L

(Zhang and Lu, 2000)

aop^yan-1 is a suppressor of eye photoreceptor cell | somatic clone phenotype of cnk^sag13L

(Zhang and Lu, 2000)

aop^yan-1 is a suppressor of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Rogge et al., 1995)

aop^yan-1 is a suppressor of phenotype of bun^rI043

(Treisman et al., 1995)

NOT Suppressor of

Statement

Reference

aop^yan-1 is a non-suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

Other

Statement

Reference

B-H1^sev.PH, aop^yan-1 has photoreceptor cell R7 | ectopic phenotype

(Hayashi et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the extra-R7 cell eye phenotype of sty²²⁶/+ heterozygotes.

(Kramer et al., 1999)

Significantly enhances the formation of extra outer photoreceptors caused by B-H1^sev.PH. aop^yan-1 flies carrying B-H1^sev.PH have a considerable number of extra R7-like cells.

(Hayashi et al., 1998)

The extra outer photoreceptor cell phenotype seen in faf^BX4 homozygotes is dominantly enhanced by aop^yan-1, with the average number of outer photoreceptor cells per ommatidium being increased to 8.7.

(Isaksson et al., 1997)

Loss of wild type ttk promotes the formation of rare ectopic R7 cells.

(Lai et al., 1997)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Enhancer of the dosage-dependent (two or more copies of P{sev-svp1} or P{sev-svp2}) transformation of cone cells into R7 photoreceptors and at a lower frequency R7 cells into outer photoreceptors.

(Begemann et al., 1995)

sev⁶/sev⁺; Sos^JC2/aop^pok-x8 mutants exhibit an increase in the number of R7 cells compared to sev⁶/Sos^JC2 mutants with two functional aop copies.

(Rogge et al., 1995)

Dominantly enhances the rough eye phenotype of Jra^Asp.hs.sev.

(Treier et al., 1995)

Reduction in the dose of aop enhances all the defects seen in rho^hs.sev eyes.

(Freeman, 1994)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

aop^pok-x8

(Rogge et al., 1995)

Partially complements

aop^e2d

(Rogge et al., 1995)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8780

w^*; aop^yan-1/CyO, P{lacZ.w⁺}276

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

aop^Yan1

(Sarov et al., 2016)

aop^yan-1

aop^yan1

(Weng et al., 2012)

yan

(Scholz et al., 1997, Scholz et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (36)

Report Sections

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