Allele Dmel\bap²⁰⁸

General Information
Symbol	Dmel\bap²⁰⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0034201
Feature type	allele	Associated gene	Dmel\bap

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Azpiazu and Frasch, 1993)
Mutagen	ethyl methanesulfonate (Jagla et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Azpiazu and Frasch, 1993)
Phenotype Manifest In
	embryonic/larval midgut \| embryonic stage (Ranganayakulu et al., 1998) midgut muscle (Azpiazu and Frasch, 1993)
Detailed Description
	Statement Reference In bap²⁰⁸ mutant embryos, the frontal sac is normal. (Zikova et al., 2003) Embryonic cuticle is wild type. (Jagla et al., 1997) Mesoderm phenotype: reduced number of visceral mesoderm cells, the cells have irregular shapes and are not columnar. Mutation causes a transformation of a portion of cells from a visceral mesoderm fate to assume the identity of somatic or gonadal mesoderm. In the absence of visceral mesoderm the endoderm fails to migrate. Musculature of the foregut, hindgut, and the heart appear normal. (Azpiazu and Frasch, 1993)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Phenotype is not rescued by Mmus\Nkx2-5^Scer\UAS.cRa expression in the midgut. (Ranganayakulu et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	bap²⁰⁸ is rescued by bap^+t11 (Azpiazu and Frasch, 1993) bap²⁰⁸ is rescued by Scer\GAL4^twi.PB/Scer\GAL4^Mef2.PR/bap^Scer\UAS.cRa (Ranganayakulu et al., 1998)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	bap²⁰⁸
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Denholm et al., 2003, Curr. Biol. 13(12): 1052--1057 Dual origin of the renal tubules in Drosophila: mesodermal cells integrate and polarize to establish secretory function. [FBrf0160477] Zikova et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100(21): 12189--12194 Patterning of the cardiac outflow region in Drosophila. [FBrf0167997] Zaffran et al., 2001, Genes Dev. 15(21): 2900--2915 biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila. [FBrf0139672] Cripps et al., 1999, Dev. Biol. 215(2): 420--430 Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic, and visceral muscle cell lineages is regulated by a tinman-dependent core enhancer. [FBrf0111843] Gorczyca et al., 1999, J. Neurobiol. 39(3): 447--460 The gene mod(mdg4) affects synapse specificity and structure in Drosophila. [FBrf0108771] Ranganayakulu et al., 1998, Development 125(16): 3037--3048 Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice. [FBrf0104504] Jagla et al., 1997, Development 124(1): 91--100 ladybird, a tandem of homeobox genes that maintain late wingless expression in terminal and dorsal epidermis of the Drosophila embryo. [FBrf0091087] Tan et al., 1996, Genetica 97(1): 111--115 412-Positive mesodermal cells and the gonadal mesoderm are separate from the fat-cell lineage. [FBrf0086648] Bonneton and Wegnez, 1995, Dev. Genet. 16(3): 253--263 Developmental variability of metallothionein Mtn gene expression in the species of the Drosophila melanogaster subgroup. [FBrf0081471] Azpiazu and Frasch, 1993, Genes Dev. 7(7B): 1325--1340 tinman and bagpipe: two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. [FBrf0058519]

Allele Dmel\bap208

Allele Dmel\bap²⁰⁸