Allele Dmel\bb^r10

General Information
Symbol	Dmel\bb^r10	Species	D. melanogaster
Name		FlyBase ID	FBal0034205
Feature type	allele	Associated gene	Dmel\bb

Allele class
Mutagen	in vitro construct
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct (Merrill et al., 1992)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Retains six IGS repeats plus about 2kb from the 5' end of the rDNA transcription unit. (McKee et al., 1998) Construct: bb fragment extends from the 3' end of 28S through the middle of the 18S gene, includes the intergenic spacer (IGS) and external transcribed sequences (ETS). (Merrill et al., 1992)
Carried in construct	P{rib10} (Merrill et al., 1992, McKee et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Stimulates X-Y pairing in non-translocated genotypes. Increases fertility of Df(1)X-1; T(Y;2)B80 from 0 to 5.4-40.1% (depending on site of insertion). (McKee et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Heterozygotes with Dp(1;Y)B^SYy⁺ display significant stimulation of X-Y disjunction in adult testes when recombined with Df(1)X-1, in genetic and cytological assays. Effect is increased with two copies of bb^r10. No mininucleolus is formed. (Merrill et al., 1992)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	bb^r10
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	McKee et al., 1998, Genetics 149(1): 143--155 Male sterility and meiotic drive associated with sex chromosome rearrangements in Drosophila. Role of X-Y pairing. [FBrf0102838] Merrill et al., 1992, Dev. Genet. 13(6): 468--484 Promoter-containing ribosomal DNA fragments function as X-Y meiotic pairing sites in D. melanogaster males. [FBrf0055833]

Allele Dmel\bbr10

Allele Dmel\bb^r10